| Full name: transmembrane channel like 2 | Alias Symbol: dJ686C3.3 | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 117532 | HGNC ID: HGNC:16527 | Ensembl Gene: ENSG00000149488 | OMIM ID: 606707 |
| Drug and gene relationship at DGIdb | |||
Expression of TMC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMC2 | 117532 | 1553019_at | -0.2662 | 0.1756 | |
| GSE26886 | TMC2 | 117532 | 1553019_at | -0.2805 | 0.0275 | |
| GSE45670 | TMC2 | 117532 | 1553019_at | 0.1588 | 0.1009 | |
| GSE53622 | TMC2 | 117532 | 40342 | -0.5287 | 0.0000 | |
| GSE53624 | TMC2 | 117532 | 40342 | 0.0611 | 0.5109 | |
| GSE63941 | TMC2 | 117532 | 1553019_at | 0.1406 | 0.3263 | |
| GSE77861 | TMC2 | 117532 | 1553019_at | -0.0761 | 0.5663 | |
| GSE97050 | TMC2 | 117532 | A_23_P305527 | 0.1394 | 0.5932 | |
| TCGA | TMC2 | 117532 | RNAseq | -0.0014 | 0.9985 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TMC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMC2 | 117532 | 12 | 4 | 14 | |
| GSE20123 | TMC2 | 117532 | 13 | 4 | 13 | |
| GSE43470 | TMC2 | 117532 | 11 | 1 | 31 | |
| GSE46452 | TMC2 | 117532 | 26 | 1 | 32 | |
| GSE47630 | TMC2 | 117532 | 18 | 4 | 18 | |
| GSE54993 | TMC2 | 117532 | 2 | 14 | 54 | |
| GSE54994 | TMC2 | 117532 | 24 | 2 | 27 | |
| GSE60625 | TMC2 | 117532 | 0 | 0 | 11 | |
| GSE74703 | TMC2 | 117532 | 10 | 1 | 25 | |
| GSE74704 | TMC2 | 117532 | 8 | 1 | 11 | |
| TCGA | TMC2 | 117532 | 40 | 11 | 45 |
Total number of gains: 164; Total number of losses: 43; Total Number of normals: 281.
Somatic mutations of TMC2:
Generating mutation plots.
Highly correlated genes for TMC2:
Showing top 20/115 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMC2 | TNP2 | 0.73746 | 3 | 0 | 3 |
| TMC2 | KLK4 | 0.713956 | 3 | 0 | 3 |
| TMC2 | LUZP2 | 0.713188 | 4 | 0 | 4 |
| TMC2 | SYN1 | 0.704964 | 3 | 0 | 3 |
| TMC2 | CIITA | 0.694724 | 3 | 0 | 3 |
| TMC2 | LILRA2 | 0.686789 | 4 | 0 | 4 |
| TMC2 | SAMD15 | 0.672496 | 5 | 0 | 4 |
| TMC2 | ARL2BP | 0.667281 | 3 | 0 | 3 |
| TMC2 | CNTD1 | 0.666702 | 3 | 0 | 3 |
| TMC2 | C2orf16 | 0.666499 | 4 | 0 | 4 |
| TMC2 | TTLL10 | 0.661423 | 3 | 0 | 3 |
| TMC2 | KLRG1 | 0.659706 | 3 | 0 | 3 |
| TMC2 | HHLA1 | 0.658369 | 3 | 0 | 3 |
| TMC2 | LATS2 | 0.655786 | 3 | 0 | 3 |
| TMC2 | UTY | 0.654921 | 3 | 0 | 3 |
| TMC2 | KCNJ5 | 0.651307 | 3 | 0 | 3 |
| TMC2 | NHSL2 | 0.643933 | 3 | 0 | 3 |
| TMC2 | TLR5 | 0.643238 | 3 | 0 | 3 |
| TMC2 | TSSK2 | 0.642547 | 3 | 0 | 3 |
| TMC2 | TIMM23 | 0.636008 | 3 | 0 | 3 |
For details and further investigation, click here
