| Full name: laminin subunit alpha 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 3911 | HGNC ID: HGNC:6485 | Ensembl Gene: ENSG00000130702 | OMIM ID: 601033 |
| Drug and gene relationship at DGIdb | |||
LAMA5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of LAMA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAMA5 | 3911 | 210150_s_at | 1.0730 | 0.0781 | |
| GSE20347 | LAMA5 | 3911 | 210150_s_at | 0.6562 | 0.0000 | |
| GSE23400 | LAMA5 | 3911 | 210150_s_at | 0.3807 | 0.0002 | |
| GSE26886 | LAMA5 | 3911 | 210150_s_at | 1.3124 | 0.0000 | |
| GSE29001 | LAMA5 | 3911 | 210150_s_at | 0.6212 | 0.0530 | |
| GSE38129 | LAMA5 | 3911 | 210150_s_at | 0.4255 | 0.0030 | |
| GSE45670 | LAMA5 | 3911 | 210150_s_at | 0.3473 | 0.0726 | |
| GSE53622 | LAMA5 | 3911 | 48676 | 0.1728 | 0.0008 | |
| GSE53624 | LAMA5 | 3911 | 48676 | 0.3192 | 0.0000 | |
| GSE63941 | LAMA5 | 3911 | 210150_s_at | 2.2718 | 0.0011 | |
| GSE77861 | LAMA5 | 3911 | 210150_s_at | 0.6745 | 0.0529 | |
| GSE97050 | LAMA5 | 3911 | A_33_P3384442 | -0.0038 | 0.9885 | |
| SRP007169 | LAMA5 | 3911 | RNAseq | 0.5625 | 0.1982 | |
| SRP008496 | LAMA5 | 3911 | RNAseq | 0.4268 | 0.1171 | |
| SRP064894 | LAMA5 | 3911 | RNAseq | 0.7415 | 0.0132 | |
| SRP133303 | LAMA5 | 3911 | RNAseq | 0.1244 | 0.4912 | |
| SRP159526 | LAMA5 | 3911 | RNAseq | 0.2971 | 0.2461 | |
| SRP193095 | LAMA5 | 3911 | RNAseq | 0.8817 | 0.0000 | |
| SRP219564 | LAMA5 | 3911 | RNAseq | 0.6099 | 0.0884 | |
| TCGA | LAMA5 | 3911 | RNAseq | 0.1326 | 0.0166 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LAMA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAMA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAMA5 | 3911 | 13 | 2 | 15 | |
| GSE20123 | LAMA5 | 3911 | 14 | 2 | 14 | |
| GSE43470 | LAMA5 | 3911 | 11 | 1 | 31 | |
| GSE46452 | LAMA5 | 3911 | 35 | 0 | 24 | |
| GSE47630 | LAMA5 | 3911 | 25 | 1 | 14 | |
| GSE54993 | LAMA5 | 3911 | 0 | 17 | 53 | |
| GSE54994 | LAMA5 | 3911 | 29 | 0 | 24 | |
| GSE60625 | LAMA5 | 3911 | 0 | 0 | 11 | |
| GSE74703 | LAMA5 | 3911 | 10 | 0 | 26 | |
| GSE74704 | LAMA5 | 3911 | 11 | 0 | 9 | |
| TCGA | LAMA5 | 3911 | 43 | 4 | 49 |
Total number of gains: 191; Total number of losses: 27; Total Number of normals: 270.
Somatic mutations of LAMA5:
Generating mutation plots.
Highly correlated genes for LAMA5:
Showing top 20/502 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAMA5 | HSF2BP | 0.774152 | 3 | 0 | 3 |
| LAMA5 | FAM24B | 0.757935 | 3 | 0 | 3 |
| LAMA5 | ZNF511 | 0.74241 | 4 | 0 | 4 |
| LAMA5 | STK32C | 0.742279 | 3 | 0 | 3 |
| LAMA5 | ZNF687 | 0.739779 | 3 | 0 | 3 |
| LAMA5 | MRGPRG | 0.725829 | 3 | 0 | 3 |
| LAMA5 | ARHGAP22 | 0.725267 | 4 | 0 | 3 |
| LAMA5 | NAT14 | 0.723361 | 3 | 0 | 3 |
| LAMA5 | FBRSL1 | 0.715116 | 7 | 0 | 6 |
| LAMA5 | SURF2 | 0.710654 | 3 | 0 | 3 |
| LAMA5 | FOXRED1 | 0.710614 | 3 | 0 | 3 |
| LAMA5 | LINC00467 | 0.710341 | 3 | 0 | 3 |
| LAMA5 | RRP1 | 0.702722 | 3 | 0 | 3 |
| LAMA5 | PRSS38 | 0.701549 | 3 | 0 | 3 |
| LAMA5 | IL31RA | 0.701107 | 3 | 0 | 3 |
| LAMA5 | OR2T27 | 0.695159 | 3 | 0 | 3 |
| LAMA5 | OR2T1 | 0.691519 | 3 | 0 | 3 |
| LAMA5 | OR2B11 | 0.690201 | 3 | 0 | 3 |
| LAMA5 | ELOVL3 | 0.690013 | 4 | 0 | 4 |
| LAMA5 | YY2 | 0.689906 | 3 | 0 | 3 |
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