| Full name: ribosomal RNA processing 1 | Alias Symbol: NNP-1|Nop52|NOP52|RRP1A|D21S2056E | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 8568 | HGNC ID: HGNC:18785 | Ensembl Gene: ENSG00000160214 | OMIM ID: 610653 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RRP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RRP1 | 8568 | 218758_s_at | 0.4343 | 0.3285 | |
| GSE20347 | RRP1 | 8568 | 218758_s_at | 0.0459 | 0.6642 | |
| GSE23400 | RRP1 | 8568 | 218758_s_at | 0.0089 | 0.8920 | |
| GSE26886 | RRP1 | 8568 | 218758_s_at | 0.3488 | 0.1050 | |
| GSE29001 | RRP1 | 8568 | 218758_s_at | 0.0415 | 0.8831 | |
| GSE38129 | RRP1 | 8568 | 218758_s_at | 0.1997 | 0.0793 | |
| GSE45670 | RRP1 | 8568 | 218758_s_at | 0.1509 | 0.2814 | |
| GSE53622 | RRP1 | 8568 | 18680 | -0.9995 | 0.0000 | |
| GSE53624 | RRP1 | 8568 | 18680 | -0.8857 | 0.0000 | |
| GSE63941 | RRP1 | 8568 | 218758_s_at | 0.2930 | 0.3620 | |
| GSE77861 | RRP1 | 8568 | 222733_x_at | -0.0714 | 0.7012 | |
| GSE97050 | RRP1 | 8568 | A_23_P80136 | -0.3709 | 0.3062 | |
| SRP007169 | RRP1 | 8568 | RNAseq | 1.3121 | 0.1095 | |
| SRP064894 | RRP1 | 8568 | RNAseq | 0.5152 | 0.0600 | |
| SRP133303 | RRP1 | 8568 | RNAseq | -0.2679 | 0.1184 | |
| SRP159526 | RRP1 | 8568 | RNAseq | 0.0372 | 0.8921 | |
| SRP193095 | RRP1 | 8568 | RNAseq | 0.1353 | 0.3172 | |
| SRP219564 | RRP1 | 8568 | RNAseq | 0.1339 | 0.8041 | |
| TCGA | RRP1 | 8568 | RNAseq | 0.2260 | 0.0010 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RRP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RRP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RRP1 | 8568 | 2 | 8 | 20 | |
| GSE20123 | RRP1 | 8568 | 2 | 8 | 20 | |
| GSE43470 | RRP1 | 8568 | 0 | 13 | 30 | |
| GSE46452 | RRP1 | 8568 | 1 | 21 | 37 | |
| GSE47630 | RRP1 | 8568 | 6 | 17 | 17 | |
| GSE54993 | RRP1 | 8568 | 8 | 1 | 61 | |
| GSE54994 | RRP1 | 8568 | 4 | 8 | 41 | |
| GSE60625 | RRP1 | 8568 | 0 | 0 | 11 | |
| GSE74703 | RRP1 | 8568 | 0 | 10 | 26 | |
| GSE74704 | RRP1 | 8568 | 1 | 4 | 15 | |
| TCGA | RRP1 | 8568 | 8 | 39 | 49 |
Total number of gains: 32; Total number of losses: 129; Total Number of normals: 327.
Somatic mutations of RRP1:
Generating mutation plots.
Highly correlated genes for RRP1:
Showing top 20/352 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RRP1 | KRTAP20-1 | 0.935586 | 3 | 0 | 3 |
| RRP1 | OR2Z1 | 0.921051 | 3 | 0 | 3 |
| RRP1 | MFSD2B | 0.905391 | 3 | 0 | 3 |
| RRP1 | OR10G8 | 0.870068 | 3 | 0 | 3 |
| RRP1 | FAM163B | 0.843398 | 3 | 0 | 3 |
| RRP1 | BARHL2 | 0.814302 | 3 | 0 | 3 |
| RRP1 | TEN1 | 0.814137 | 3 | 0 | 3 |
| RRP1 | KRTAP6-1 | 0.802153 | 3 | 0 | 3 |
| RRP1 | NCCRP1 | 0.800161 | 3 | 0 | 3 |
| RRP1 | CLDN24 | 0.797387 | 3 | 0 | 3 |
| RRP1 | MUC22 | 0.796203 | 3 | 0 | 3 |
| RRP1 | OTOP3 | 0.79102 | 3 | 0 | 3 |
| RRP1 | ZNF283 | 0.788044 | 3 | 0 | 3 |
| RRP1 | KRTAP4-1 | 0.780909 | 4 | 0 | 4 |
| RRP1 | OR10G3 | 0.780433 | 3 | 0 | 3 |
| RRP1 | ARHGAP30 | 0.778522 | 3 | 0 | 3 |
| RRP1 | TPRX1 | 0.768891 | 3 | 0 | 3 |
| RRP1 | SLC37A1 | 0.756651 | 3 | 0 | 3 |
| RRP1 | ODF4 | 0.755283 | 3 | 0 | 3 |
| RRP1 | KPRP | 0.754285 | 3 | 0 | 3 |
For details and further investigation, click here
