| Full name: Rho GTPase activating protein 22 | Alias Symbol: RhoGAP2 | ||
| Type: protein-coding gene | Cytoband: 10q11.22-q11.23 | ||
| Entrez ID: 58504 | HGNC ID: HGNC:30320 | Ensembl Gene: ENSG00000128805 | OMIM ID: 610585 |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGAP22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGAP22 | 58504 | 206298_at | 0.3932 | 0.2983 | |
| GSE20347 | ARHGAP22 | 58504 | 206298_at | 0.0754 | 0.4087 | |
| GSE23400 | ARHGAP22 | 58504 | 206298_at | -0.0191 | 0.6149 | |
| GSE26886 | ARHGAP22 | 58504 | 206298_at | 0.8843 | 0.0034 | |
| GSE29001 | ARHGAP22 | 58504 | 206298_at | 0.4996 | 0.0946 | |
| GSE38129 | ARHGAP22 | 58504 | 206298_at | 0.1225 | 0.4455 | |
| GSE45670 | ARHGAP22 | 58504 | 206298_at | 0.2241 | 0.2329 | |
| GSE53622 | ARHGAP22 | 58504 | 72082 | 0.2985 | 0.0001 | |
| GSE53624 | ARHGAP22 | 58504 | 72082 | -0.1449 | 0.0983 | |
| GSE97050 | ARHGAP22 | 58504 | A_23_P75310 | 0.0773 | 0.7158 | |
| SRP064894 | ARHGAP22 | 58504 | RNAseq | 1.3110 | 0.0000 | |
| SRP133303 | ARHGAP22 | 58504 | RNAseq | 0.2665 | 0.0736 | |
| SRP159526 | ARHGAP22 | 58504 | RNAseq | -0.0852 | 0.8535 | |
| SRP193095 | ARHGAP22 | 58504 | RNAseq | 0.4368 | 0.0020 | |
| SRP219564 | ARHGAP22 | 58504 | RNAseq | 0.8355 | 0.0343 | |
| TCGA | ARHGAP22 | 58504 | RNAseq | 0.4254 | 0.0111 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ARHGAP22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGAP22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGAP22 | 58504 | 2 | 5 | 23 | |
| GSE20123 | ARHGAP22 | 58504 | 2 | 5 | 23 | |
| GSE43470 | ARHGAP22 | 58504 | 2 | 6 | 35 | |
| GSE46452 | ARHGAP22 | 58504 | 0 | 13 | 46 | |
| GSE47630 | ARHGAP22 | 58504 | 4 | 12 | 24 | |
| GSE54993 | ARHGAP22 | 58504 | 9 | 0 | 61 | |
| GSE54994 | ARHGAP22 | 58504 | 2 | 10 | 41 | |
| GSE60625 | ARHGAP22 | 58504 | 0 | 0 | 11 | |
| GSE74703 | ARHGAP22 | 58504 | 2 | 3 | 31 | |
| GSE74704 | ARHGAP22 | 58504 | 1 | 4 | 15 | |
| TCGA | ARHGAP22 | 58504 | 13 | 22 | 61 |
Total number of gains: 37; Total number of losses: 80; Total Number of normals: 371.
Somatic mutations of ARHGAP22:
Generating mutation plots.
Highly correlated genes for ARHGAP22:
Showing top 20/136 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGAP22 | FBRSL1 | 0.823403 | 3 | 0 | 3 |
| ARHGAP22 | HOXC9 | 0.809306 | 3 | 0 | 3 |
| ARHGAP22 | GTF2IRD2 | 0.796848 | 3 | 0 | 3 |
| ARHGAP22 | CCDC142 | 0.796586 | 3 | 0 | 3 |
| ARHGAP22 | PLEC | 0.762271 | 3 | 0 | 3 |
| ARHGAP22 | TMEM52 | 0.756867 | 3 | 0 | 3 |
| ARHGAP22 | NPW | 0.756031 | 3 | 0 | 3 |
| ARHGAP22 | GEMIN2 | 0.752748 | 3 | 0 | 3 |
| ARHGAP22 | TNFAIP8L1 | 0.751925 | 3 | 0 | 3 |
| ARHGAP22 | LONP1 | 0.726292 | 4 | 0 | 3 |
| ARHGAP22 | LAMA5 | 0.725267 | 4 | 0 | 3 |
| ARHGAP22 | BCL2L12 | 0.718086 | 3 | 0 | 3 |
| ARHGAP22 | RNF44 | 0.711612 | 3 | 0 | 3 |
| ARHGAP22 | DUSP9 | 0.710587 | 5 | 0 | 5 |
| ARHGAP22 | FZD9 | 0.70824 | 3 | 0 | 3 |
| ARHGAP22 | HSPBAP1 | 0.70368 | 3 | 0 | 3 |
| ARHGAP22 | PHACTR3 | 0.701669 | 3 | 0 | 3 |
| ARHGAP22 | TSPAN10 | 0.701011 | 4 | 0 | 4 |
| ARHGAP22 | CDCA5 | 0.700767 | 3 | 0 | 3 |
| ARHGAP22 | TONSL | 0.699731 | 3 | 0 | 3 |
For details and further investigation, click here
