| Full name: linker for activation of T cells family member 2 | Alias Symbol: WSCR5|HSPC046|LAB|NTAL | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 7462 | HGNC ID: HGNC:12749 | Ensembl Gene: ENSG00000086730 | OMIM ID: 605719 |
| Drug and gene relationship at DGIdb | |||
Expression of LAT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAT2 | 7462 | 221581_s_at | 0.2264 | 0.8344 | |
| GSE20347 | LAT2 | 7462 | 211768_at | 0.0739 | 0.5381 | |
| GSE23400 | LAT2 | 7462 | 211768_at | -0.0923 | 0.0492 | |
| GSE26886 | LAT2 | 7462 | 221581_s_at | -0.1639 | 0.4035 | |
| GSE29001 | LAT2 | 7462 | 211768_at | 0.0065 | 0.9699 | |
| GSE38129 | LAT2 | 7462 | 221581_s_at | 0.1081 | 0.5985 | |
| GSE45670 | LAT2 | 7462 | 221581_s_at | 0.1733 | 0.4191 | |
| GSE53622 | LAT2 | 7462 | 915 | 0.5130 | 0.0000 | |
| GSE53624 | LAT2 | 7462 | 915 | 0.2009 | 0.0126 | |
| GSE63941 | LAT2 | 7462 | 221581_s_at | 0.3542 | 0.3834 | |
| GSE77861 | LAT2 | 7462 | 211768_at | -0.0087 | 0.9566 | |
| GSE97050 | LAT2 | 7462 | A_33_P3294961 | 0.0655 | 0.7673 | |
| SRP007169 | LAT2 | 7462 | RNAseq | 1.3159 | 0.0468 | |
| SRP008496 | LAT2 | 7462 | RNAseq | 0.8576 | 0.0827 | |
| SRP064894 | LAT2 | 7462 | RNAseq | 0.8025 | 0.0003 | |
| SRP133303 | LAT2 | 7462 | RNAseq | 0.3698 | 0.1284 | |
| SRP159526 | LAT2 | 7462 | RNAseq | -0.3859 | 0.5281 | |
| SRP193095 | LAT2 | 7462 | RNAseq | 0.6619 | 0.0002 | |
| SRP219564 | LAT2 | 7462 | RNAseq | 1.1015 | 0.0260 | |
| TCGA | LAT2 | 7462 | RNAseq | 0.3323 | 0.0170 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LAT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAT2 | 7462 | 14 | 1 | 15 | |
| GSE20123 | LAT2 | 7462 | 14 | 1 | 15 | |
| GSE43470 | LAT2 | 7462 | 3 | 2 | 38 | |
| GSE46452 | LAT2 | 7462 | 12 | 0 | 47 | |
| GSE47630 | LAT2 | 7462 | 7 | 2 | 31 | |
| GSE54993 | LAT2 | 7462 | 2 | 7 | 61 | |
| GSE54994 | LAT2 | 7462 | 13 | 3 | 37 | |
| GSE60625 | LAT2 | 7462 | 0 | 0 | 11 | |
| GSE74703 | LAT2 | 7462 | 3 | 1 | 32 | |
| GSE74704 | LAT2 | 7462 | 8 | 1 | 11 | |
| TCGA | LAT2 | 7462 | 45 | 7 | 44 |
Total number of gains: 121; Total number of losses: 25; Total Number of normals: 342.
Somatic mutations of LAT2:
Generating mutation plots.
Highly correlated genes for LAT2:
Showing top 20/485 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAT2 | KLF17 | 0.855265 | 3 | 0 | 3 |
| LAT2 | MDH1B | 0.830952 | 3 | 0 | 3 |
| LAT2 | TNFAIP8L1 | 0.814408 | 3 | 0 | 3 |
| LAT2 | C9orf153 | 0.807795 | 3 | 0 | 3 |
| LAT2 | BFSP2-AS1 | 0.757625 | 3 | 0 | 3 |
| LAT2 | RNF180 | 0.755042 | 3 | 0 | 3 |
| LAT2 | VWA5B1 | 0.750637 | 4 | 0 | 4 |
| LAT2 | MIR142 | 0.744352 | 3 | 0 | 3 |
| LAT2 | LBX2 | 0.735552 | 3 | 0 | 3 |
| LAT2 | SLC30A3 | 0.734703 | 3 | 0 | 3 |
| LAT2 | MRGPRG | 0.72153 | 3 | 0 | 3 |
| LAT2 | JRK | 0.720068 | 4 | 0 | 4 |
| LAT2 | PRLHR | 0.705187 | 3 | 0 | 3 |
| LAT2 | SIRPB1 | 0.70506 | 6 | 0 | 5 |
| LAT2 | OSM | 0.698476 | 3 | 0 | 3 |
| LAT2 | GRK6 | 0.69509 | 3 | 0 | 3 |
| LAT2 | TSR1 | 0.693219 | 4 | 0 | 3 |
| LAT2 | WDR87 | 0.692549 | 3 | 0 | 3 |
| LAT2 | YY2 | 0.691469 | 3 | 0 | 3 |
| LAT2 | BMP8B | 0.688374 | 4 | 0 | 3 |
For details and further investigation, click here
