GRK6

 

Full name: G protein-coupled receptor kinase 6 Alias Symbol: 
Type: protein-coding gene Cytoband: 5q35.3
Entrez ID: 2870 HGNC ID: HGNC:4545 Ensembl Gene: ENSG00000198055 OMIM ID: 600869
Drug and gene relationship at DGIdb

 

GRK6 involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa05032Morphine addiction

 

Expression of GRK6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GRK6 2870 202849_x_at 0.4331 0.0854
GSE20347 GRK6 2870 202849_x_at 0.0003 0.9983
GSE23400 GRK6 2870 202849_x_at -0.0720 0.0812
GSE26886 GRK6 2870 202849_x_at 0.1168 0.4824
GSE29001 GRK6 2870 202849_x_at -0.1546 0.4942
GSE38129 GRK6 2870 202849_x_at -0.0365 0.6676
GSE45670 GRK6 2870 210981_s_at 0.1922 0.0845
GSE53622 GRK6 2870 57522 0.2302 0.0050
GSE53624 GRK6 2870 57522 0.3809 0.0000
GSE63941 GRK6 2870 202849_x_at 0.5390 0.0085
GSE77861 GRK6 2870 202849_x_at -0.0859 0.2550
GSE97050 GRK6 2870 A_33_P3264875 0.3056 0.3180
SRP007169 GRK6 2870 RNAseq -0.5385 0.2060
SRP008496 GRK6 2870 RNAseq -0.3977 0.1607
SRP064894 GRK6 2870 RNAseq 0.0950 0.6566
SRP133303 GRK6 2870 RNAseq -0.0231 0.9026
SRP159526 GRK6 2870 RNAseq 0.0105 0.9741
SRP193095 GRK6 2870 RNAseq 0.2883 0.0132
SRP219564 GRK6 2870 RNAseq -0.0770 0.8125
TCGA GRK6 2870 RNAseq 0.1367 0.0101

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GRK6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GRK6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GRK6 2870 2 13 15
GSE20123 GRK6 2870 2 13 15
GSE43470 GRK6 2870 1 11 31
GSE46452 GRK6 2870 0 27 32
GSE47630 GRK6 2870 1 20 19
GSE54993 GRK6 2870 10 2 58
GSE54994 GRK6 2870 2 17 34
GSE60625 GRK6 2870 1 0 10
GSE74703 GRK6 2870 1 7 28
GSE74704 GRK6 2870 1 6 13
TCGA GRK6 2870 8 34 54

Total number of gains: 29; Total number of losses: 150; Total Number of normals: 309.  

 

Somatic mutations of GRK6:

 

Generating mutation plots.

 

Highly correlated genes for GRK6:

 

Showing top 20/776 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GRK6KRTAP5-80.727638505
GRK6CACFD10.725105505
GRK6RAD51D0.721218303
GRK6KLC40.71079303
GRK6CGA0.697918404
GRK6GPR310.696013404
GRK6LAT20.69509303
GRK6TARBP20.687448403
GRK6NPHS20.686827404
GRK6ZNF5800.685057303
GRK6OVGP10.677802504
GRK6CAMK2B0.676863605
GRK6ZNF7470.675252605
GRK6ASCL10.674521303
GRK6RNF185-AS10.666115404
GRK6P2RX60.666042505
GRK6MIER20.664604403
GRK6SIRT30.661635605
GRK6OTX10.660259303
GRK6C8A0.659134504

For details and further investigation, click here