| Full name: malate dehydrogenase 1B | Alias Symbol: FLJ25341|RP11-95H11 | ||
| Type: protein-coding gene | Cytoband: 2q33.3 | ||
| Entrez ID: 130752 | HGNC ID: HGNC:17836 | Ensembl Gene: ENSG00000138400 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of MDH1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MDH1B | 130752 | 238721_at | -0.1369 | 0.7899 | |
| GSE26886 | MDH1B | 130752 | 238721_at | -0.0361 | 0.7701 | |
| GSE45670 | MDH1B | 130752 | 238721_at | -0.2342 | 0.0074 | |
| GSE53622 | MDH1B | 130752 | 143942 | 0.7824 | 0.0000 | |
| GSE53624 | MDH1B | 130752 | 143942 | 0.5238 | 0.0000 | |
| GSE63941 | MDH1B | 130752 | 238721_at | -0.1722 | 0.4356 | |
| GSE77861 | MDH1B | 130752 | 238721_at | -0.0122 | 0.9251 | |
| GSE97050 | MDH1B | 130752 | A_33_P3372526 | 0.0542 | 0.8317 | |
| SRP064894 | MDH1B | 130752 | RNAseq | -0.2980 | 0.2329 | |
| SRP133303 | MDH1B | 130752 | RNAseq | 0.1268 | 0.5711 | |
| SRP159526 | MDH1B | 130752 | RNAseq | 1.2114 | 0.0394 | |
| SRP193095 | MDH1B | 130752 | RNAseq | 0.3062 | 0.0416 | |
| SRP219564 | MDH1B | 130752 | RNAseq | -1.2505 | 0.0201 | |
| TCGA | MDH1B | 130752 | RNAseq | -0.2316 | 0.5583 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by MDH1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MDH1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MDH1B | 130752 | 3 | 6 | 21 | |
| GSE20123 | MDH1B | 130752 | 3 | 6 | 21 | |
| GSE43470 | MDH1B | 130752 | 2 | 4 | 37 | |
| GSE46452 | MDH1B | 130752 | 1 | 4 | 54 | |
| GSE47630 | MDH1B | 130752 | 4 | 5 | 31 | |
| GSE54993 | MDH1B | 130752 | 0 | 3 | 67 | |
| GSE54994 | MDH1B | 130752 | 8 | 9 | 36 | |
| GSE60625 | MDH1B | 130752 | 0 | 3 | 8 | |
| GSE74703 | MDH1B | 130752 | 2 | 3 | 31 | |
| GSE74704 | MDH1B | 130752 | 2 | 2 | 16 | |
| TCGA | MDH1B | 130752 | 14 | 22 | 60 |
Total number of gains: 39; Total number of losses: 67; Total Number of normals: 382.
Somatic mutations of MDH1B:
Generating mutation plots.
Highly correlated genes for MDH1B:
Showing top 20/62 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MDH1B | LAT2 | 0.830952 | 3 | 0 | 3 |
| MDH1B | F2RL3 | 0.761458 | 3 | 0 | 3 |
| MDH1B | VWA5B1 | 0.750109 | 4 | 0 | 3 |
| MDH1B | LINC01352 | 0.741099 | 3 | 0 | 3 |
| MDH1B | SLAMF9 | 0.707968 | 3 | 0 | 3 |
| MDH1B | A2M-AS1 | 0.704214 | 3 | 0 | 3 |
| MDH1B | ZNF445 | 0.698829 | 4 | 0 | 3 |
| MDH1B | TCF23 | 0.694436 | 3 | 0 | 3 |
| MDH1B | LINC01122 | 0.693253 | 3 | 0 | 3 |
| MDH1B | LINC01101 | 0.685286 | 3 | 0 | 3 |
| MDH1B | KRTAP10-3 | 0.683857 | 3 | 0 | 3 |
| MDH1B | ZNF667 | 0.677128 | 4 | 0 | 3 |
| MDH1B | ARMCX4 | 0.668127 | 4 | 0 | 3 |
| MDH1B | ZNF236 | 0.662618 | 3 | 0 | 3 |
| MDH1B | CASC2 | 0.653451 | 3 | 0 | 3 |
| MDH1B | LINC00266-1 | 0.653193 | 3 | 0 | 3 |
| MDH1B | OR1L6 | 0.652285 | 3 | 0 | 3 |
| MDH1B | ZMAT1 | 0.649284 | 3 | 0 | 3 |
| MDH1B | FOXP3 | 0.632392 | 3 | 0 | 3 |
| MDH1B | CLEC4E | 0.628654 | 3 | 0 | 3 |
For details and further investigation, click here
