| Full name: signal regulatory protein beta 1 | Alias Symbol: SIRP-BETA-1|CD172b | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 10326 | HGNC ID: HGNC:15928 | Ensembl Gene: ENSG00000101307 | OMIM ID: 603889 |
| Drug and gene relationship at DGIdb | |||
SIRPB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation |
Expression of SIRPB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIRPB1 | 10326 | 217240_at | -0.0774 | 0.7481 | |
| GSE20347 | SIRPB1 | 10326 | 217240_at | 0.1595 | 0.0797 | |
| GSE23400 | SIRPB1 | 10326 | 217240_at | -0.0672 | 0.1094 | |
| GSE26886 | SIRPB1 | 10326 | 217240_at | 0.0382 | 0.7923 | |
| GSE29001 | SIRPB1 | 10326 | 217240_at | -0.1115 | 0.7458 | |
| GSE38129 | SIRPB1 | 10326 | 217240_at | -0.0414 | 0.8021 | |
| GSE45670 | SIRPB1 | 10326 | 217240_at | 0.1107 | 0.2727 | |
| GSE53622 | SIRPB1 | 10326 | 45862 | 0.5999 | 0.0000 | |
| GSE53624 | SIRPB1 | 10326 | 45862 | 0.4337 | 0.0001 | |
| GSE63941 | SIRPB1 | 10326 | 217240_at | 0.4398 | 0.0086 | |
| GSE77861 | SIRPB1 | 10326 | 217240_at | -0.0143 | 0.9128 | |
| GSE97050 | SIRPB1 | 10326 | A_33_P3248072 | -0.0009 | 0.9975 | |
| SRP133303 | SIRPB1 | 10326 | RNAseq | 1.1891 | 0.0142 | |
| SRP193095 | SIRPB1 | 10326 | RNAseq | 1.3796 | 0.0000 | |
| TCGA | SIRPB1 | 10326 | RNAseq | 0.4766 | 0.0046 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SIRPB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIRPB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIRPB1 | 10326 | 13 | 3 | 14 | |
| GSE20123 | SIRPB1 | 10326 | 14 | 3 | 13 | |
| GSE43470 | SIRPB1 | 10326 | 11 | 1 | 31 | |
| GSE46452 | SIRPB1 | 10326 | 26 | 1 | 32 | |
| GSE47630 | SIRPB1 | 10326 | 19 | 4 | 17 | |
| GSE54993 | SIRPB1 | 10326 | 2 | 14 | 54 | |
| GSE54994 | SIRPB1 | 10326 | 24 | 2 | 27 | |
| GSE60625 | SIRPB1 | 10326 | 0 | 0 | 11 | |
| GSE74703 | SIRPB1 | 10326 | 10 | 1 | 25 | |
| GSE74704 | SIRPB1 | 10326 | 9 | 1 | 10 | |
| TCGA | SIRPB1 | 10326 | 40 | 11 | 45 |
Total number of gains: 168; Total number of losses: 41; Total Number of normals: 279.
Somatic mutations of SIRPB1:
Generating mutation plots.
Highly correlated genes for SIRPB1:
Showing top 20/701 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIRPB1 | RBM17 | 0.782192 | 3 | 0 | 3 |
| SIRPB1 | SLC52A1 | 0.779265 | 3 | 0 | 3 |
| SIRPB1 | HCG18 | 0.774694 | 3 | 0 | 3 |
| SIRPB1 | KRTAP10-3 | 0.738445 | 3 | 0 | 3 |
| SIRPB1 | LIPE-AS1 | 0.735587 | 3 | 0 | 3 |
| SIRPB1 | C9orf153 | 0.731306 | 3 | 0 | 3 |
| SIRPB1 | MASP2 | 0.727683 | 3 | 0 | 3 |
| SIRPB1 | TCF23 | 0.727092 | 3 | 0 | 3 |
| SIRPB1 | LINC01432 | 0.718563 | 3 | 0 | 3 |
| SIRPB1 | NOP14-AS1 | 0.705214 | 4 | 0 | 4 |
| SIRPB1 | LAT2 | 0.70506 | 6 | 0 | 5 |
| SIRPB1 | GHSR | 0.697737 | 4 | 0 | 3 |
| SIRPB1 | LINC00917 | 0.697664 | 3 | 0 | 3 |
| SIRPB1 | RNASEH2B | 0.69639 | 3 | 0 | 3 |
| SIRPB1 | KCNJ9 | 0.694498 | 6 | 0 | 5 |
| SIRPB1 | SPTB | 0.693468 | 3 | 0 | 3 |
| SIRPB1 | PLXNB3 | 0.692747 | 4 | 0 | 3 |
| SIRPB1 | HRH2 | 0.692574 | 3 | 0 | 3 |
| SIRPB1 | FSCN3 | 0.688805 | 7 | 0 | 6 |
| SIRPB1 | LINC00930 | 0.688142 | 5 | 0 | 3 |
For details and further investigation, click here
