BMP8B

 

Full name: bone morphogenetic protein 8b Alias Symbol: OP-2
Type: protein-coding gene Cytoband: 1p34.2
Entrez ID: 656 HGNC ID: HGNC:1075 Ensembl Gene: ENSG00000116985 OMIM ID: 602284
Drug and gene relationship at DGIdb

 

BMP8B involved pathways:

KEGG pathway Description View
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway

 

Expression of BMP8B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BMP8B 656 235275_at 0.9925 0.0406
GSE20347 BMP8B 656 207865_s_at 0.0861 0.2603
GSE23400 BMP8B 656 207865_s_at -0.0360 0.2743
GSE26886 BMP8B 656 235275_at 0.8472 0.0000
GSE29001 BMP8B 656 207865_s_at -0.0611 0.7593
GSE38129 BMP8B 656 207865_s_at 0.1009 0.3214
GSE45670 BMP8B 656 235275_at 0.3841 0.0704
GSE53622 BMP8B 656 114838 0.5523 0.0000
GSE53624 BMP8B 656 114838 0.4261 0.0000
GSE63941 BMP8B 656 235275_at 1.2029 0.0114
GSE77861 BMP8B 656 235275_at 0.1592 0.4156
GSE97050 BMP8B 656 A_33_P3365878 0.1199 0.5661
SRP007169 BMP8B 656 RNAseq 1.2719 0.0604
SRP064894 BMP8B 656 RNAseq 0.9997 0.0027
SRP133303 BMP8B 656 RNAseq 0.5413 0.0303
SRP159526 BMP8B 656 RNAseq 3.0660 0.0000
SRP193095 BMP8B 656 RNAseq 0.8028 0.0000
SRP219564 BMP8B 656 RNAseq 1.7413 0.0057
TCGA BMP8B 656 RNAseq 0.2907 0.0973

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by BMP8B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BMP8B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BMP8B 656 3 4 23
GSE20123 BMP8B 656 2 3 25
GSE43470 BMP8B 656 8 2 33
GSE46452 BMP8B 656 4 1 54
GSE47630 BMP8B 656 9 2 29
GSE54993 BMP8B 656 0 1 69
GSE54994 BMP8B 656 13 2 38
GSE60625 BMP8B 656 0 0 11
GSE74703 BMP8B 656 7 1 28
GSE74704 BMP8B 656 1 0 19
TCGA BMP8B 656 16 16 64

Total number of gains: 63; Total number of losses: 32; Total Number of normals: 393.  

 

Somatic mutations of BMP8B:

 

Generating mutation plots.

 

Highly correlated genes for BMP8B:

 

Showing top 20/482 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BMP8BC9orf1530.838196303
BMP8BRAX20.815507404
BMP8BSUN50.81231303
BMP8BSTRC0.806465303
BMP8BDCDC10.803364303
BMP8BSYCN0.795387303
BMP8BEYS0.788306303
BMP8BOR2T270.770726303
BMP8BTFAP2C0.749723303
BMP8BF2RL30.740989504
BMP8BFBRSL10.740238606
BMP8BBEND30.740015605
BMP8BZBTB460.73981303
BMP8BLBX20.737701303
BMP8BMS4A180.732235303
BMP8BSHC20.730986303
BMP8BC1QL20.730327303
BMP8BTNFAIP8L10.729643807
BMP8BHOXC90.72864504
BMP8BZNF5270.726607403

For details and further investigation, click here