| Full name: TSR1 ribosome maturation factor | Alias Symbol: FLJ10534 | ||
| Type: protein-coding gene | Cytoband: 17p13.3 | ||
| Entrez ID: 55720 | HGNC ID: HGNC:25542 | Ensembl Gene: ENSG00000167721 | OMIM ID: 611214 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TSR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSR1 | 55720 | 218156_s_at | 0.6096 | 0.1333 | |
| GSE20347 | TSR1 | 55720 | 218155_x_at | 0.3673 | 0.0943 | |
| GSE23400 | TSR1 | 55720 | 218155_x_at | -0.0203 | 0.8509 | |
| GSE26886 | TSR1 | 55720 | 218156_s_at | -0.7429 | 0.0023 | |
| GSE29001 | TSR1 | 55720 | 218155_x_at | 0.1714 | 0.5028 | |
| GSE38129 | TSR1 | 55720 | 218155_x_at | 0.1471 | 0.5417 | |
| GSE45670 | TSR1 | 55720 | 218155_x_at | 0.1926 | 0.0939 | |
| GSE53622 | TSR1 | 55720 | 141710 | 0.1050 | 0.1077 | |
| GSE53624 | TSR1 | 55720 | 141710 | 0.1946 | 0.0005 | |
| GSE63941 | TSR1 | 55720 | 218156_s_at | 0.6639 | 0.1884 | |
| GSE77861 | TSR1 | 55720 | 218155_x_at | 0.4962 | 0.2035 | |
| GSE97050 | TSR1 | 55720 | A_24_P941336 | 0.0852 | 0.6985 | |
| SRP007169 | TSR1 | 55720 | RNAseq | 2.0204 | 0.0000 | |
| SRP008496 | TSR1 | 55720 | RNAseq | 2.1960 | 0.0000 | |
| SRP064894 | TSR1 | 55720 | RNAseq | 0.1615 | 0.3267 | |
| SRP133303 | TSR1 | 55720 | RNAseq | 0.1942 | 0.0544 | |
| SRP159526 | TSR1 | 55720 | RNAseq | 0.1270 | 0.6689 | |
| SRP193095 | TSR1 | 55720 | RNAseq | 0.4033 | 0.0035 | |
| SRP219564 | TSR1 | 55720 | RNAseq | 0.4787 | 0.2733 | |
| TCGA | TSR1 | 55720 | RNAseq | 0.0705 | 0.1492 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TSR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSR1 | 55720 | 4 | 2 | 24 | |
| GSE20123 | TSR1 | 55720 | 4 | 3 | 23 | |
| GSE43470 | TSR1 | 55720 | 1 | 6 | 36 | |
| GSE46452 | TSR1 | 55720 | 34 | 1 | 24 | |
| GSE47630 | TSR1 | 55720 | 7 | 1 | 32 | |
| GSE54993 | TSR1 | 55720 | 4 | 3 | 63 | |
| GSE54994 | TSR1 | 55720 | 6 | 9 | 38 | |
| GSE60625 | TSR1 | 55720 | 4 | 0 | 7 | |
| GSE74703 | TSR1 | 55720 | 1 | 3 | 32 | |
| GSE74704 | TSR1 | 55720 | 2 | 1 | 17 | |
| TCGA | TSR1 | 55720 | 17 | 22 | 57 |
Total number of gains: 84; Total number of losses: 51; Total Number of normals: 353.
Somatic mutations of TSR1:
Generating mutation plots.
Highly correlated genes for TSR1:
Showing top 20/100 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSR1 | PGF | 0.859035 | 8 | 0 | 7 |
| TSR1 | ARHGEF1 | 0.821019 | 3 | 0 | 3 |
| TSR1 | RANBP2 | 0.757188 | 3 | 0 | 3 |
| TSR1 | ING5 | 0.746483 | 3 | 0 | 3 |
| TSR1 | RABGGTB | 0.701117 | 3 | 0 | 3 |
| TSR1 | LAT2 | 0.693219 | 4 | 0 | 3 |
| TSR1 | FPR1 | 0.690836 | 4 | 0 | 3 |
| TSR1 | CDK13 | 0.68422 | 5 | 0 | 4 |
| TSR1 | TMX2 | 0.68026 | 3 | 0 | 3 |
| TSR1 | FOLH1 | 0.671983 | 4 | 0 | 3 |
| TSR1 | HAUS5 | 0.669168 | 5 | 0 | 4 |
| TSR1 | WAC-AS1 | 0.656 | 3 | 0 | 3 |
| TSR1 | RFPL2 | 0.653325 | 3 | 0 | 3 |
| TSR1 | TRMT10B | 0.652524 | 3 | 0 | 3 |
| TSR1 | IL21 | 0.647244 | 4 | 0 | 3 |
| TSR1 | KCNV1 | 0.642514 | 3 | 0 | 3 |
| TSR1 | TNFRSF25 | 0.640778 | 6 | 0 | 5 |
| TSR1 | ATG16L1 | 0.639459 | 5 | 0 | 4 |
| TSR1 | HOXC9 | 0.637721 | 4 | 0 | 3 |
| TSR1 | ZMYND8 | 0.633104 | 3 | 0 | 3 |
For details and further investigation, click here
