| Full name: metastasis associated lung adenocarcinoma transcript 1 | Alias Symbol: PRO1073|MALAT-1|NCRNA00047|HCN|NEAT2|LINC00047|mascRNA | ||
| Type: non-coding RNA | Cytoband: 11q13.1 | ||
| Entrez ID: 378938 | HGNC ID: HGNC:29665 | Ensembl Gene: ENSG00000251562 | OMIM ID: 607924 |
| Drug and gene relationship at DGIdb | |||
Expression of MALAT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MALAT1 | 378938 | 1558678_s_at | -0.3584 | 0.7650 | |
| GSE26886 | MALAT1 | 378938 | 1558678_s_at | -1.3665 | 0.0007 | |
| GSE45670 | MALAT1 | 378938 | 224567_x_at | 0.1274 | 0.3519 | |
| GSE53622 | MALAT1 | 378938 | 4841 | 0.5437 | 0.0000 | |
| GSE53624 | MALAT1 | 378938 | 4841 | 0.1953 | 0.0259 | |
| GSE63941 | MALAT1 | 378938 | 224558_s_at | -0.6629 | 0.4764 | |
| GSE77861 | MALAT1 | 378938 | 1558678_s_at | -0.0016 | 0.9972 | |
| SRP007169 | MALAT1 | 378938 | RNAseq | -1.5371 | 0.0201 | |
| SRP008496 | MALAT1 | 378938 | RNAseq | -0.8209 | 0.0936 | |
| SRP064894 | MALAT1 | 378938 | RNAseq | -0.6933 | 0.0194 | |
| SRP133303 | MALAT1 | 378938 | RNAseq | 0.0714 | 0.7465 | |
| SRP159526 | MALAT1 | 378938 | RNAseq | 0.1338 | 0.5956 | |
| SRP193095 | MALAT1 | 378938 | RNAseq | -0.7444 | 0.0046 | |
| SRP219564 | MALAT1 | 378938 | RNAseq | -0.2658 | 0.6532 | |
| TCGA | MALAT1 | 378938 | RNAseq | -0.2661 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MALAT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MALAT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MALAT1 | 378938 | 8 | 5 | 17 | |
| GSE20123 | MALAT1 | 378938 | 8 | 5 | 17 | |
| GSE43470 | MALAT1 | 378938 | 4 | 1 | 38 | |
| GSE46452 | MALAT1 | 378938 | 11 | 3 | 45 | |
| GSE47630 | MALAT1 | 378938 | 7 | 5 | 28 | |
| GSE54993 | MALAT1 | 378938 | 3 | 0 | 67 | |
| GSE54994 | MALAT1 | 378938 | 7 | 5 | 41 | |
| GSE60625 | MALAT1 | 378938 | 0 | 3 | 8 | |
| GSE74703 | MALAT1 | 378938 | 3 | 0 | 33 | |
| GSE74704 | MALAT1 | 378938 | 6 | 3 | 11 | |
| TCGA | MALAT1 | 378938 | 23 | 7 | 66 |
Total number of gains: 80; Total number of losses: 37; Total Number of normals: 371.
Somatic mutations of MALAT1:
Generating mutation plots.
Highly correlated genes for MALAT1:
Showing all 15 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MALAT1 | ZBED6 | 0.705339 | 3 | 0 | 3 |
| MALAT1 | NAA15 | 0.645836 | 3 | 0 | 3 |
| MALAT1 | NOMO3 | 0.624631 | 3 | 0 | 3 |
| MALAT1 | NEK1 | 0.620856 | 3 | 0 | 3 |
| MALAT1 | MIDN | 0.607068 | 3 | 0 | 3 |
| MALAT1 | AGAP4 | 0.604774 | 4 | 0 | 4 |
| MALAT1 | PRR14L | 0.595742 | 3 | 0 | 3 |
| MALAT1 | GCNT7 | 0.565159 | 3 | 0 | 3 |
| MALAT1 | SRRM2 | 0.549151 | 5 | 0 | 3 |
| MALAT1 | CD55 | 0.545528 | 3 | 0 | 3 |
| MALAT1 | SRSF11 | 0.526603 | 5 | 0 | 3 |
| MALAT1 | GTF2H3 | 0.515573 | 5 | 0 | 3 |
| MALAT1 | MIR205HG | 0.514331 | 5 | 0 | 3 |
| MALAT1 | AGAP9 | 0.511135 | 5 | 0 | 3 |
| MALAT1 | SLC26A6 | 0.502413 | 4 | 0 | 3 |
For details and further investigation, click here
