| Full name: general transcription factor IIH subunit 3 | Alias Symbol: BTF2|TFIIH|P34 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 2967 | HGNC ID: HGNC:4657 | Ensembl Gene: ENSG00000111358 | OMIM ID: 601750 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GTF2H3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GTF2H3 | 2967 | 222104_x_at | 0.3055 | 0.6750 | |
| GSE20347 | GTF2H3 | 2967 | 222104_x_at | 0.3858 | 0.0457 | |
| GSE23400 | GTF2H3 | 2967 | 222104_x_at | 0.1583 | 0.0063 | |
| GSE26886 | GTF2H3 | 2967 | 222104_x_at | -0.0727 | 0.8028 | |
| GSE29001 | GTF2H3 | 2967 | 222104_x_at | 0.3325 | 0.1547 | |
| GSE38129 | GTF2H3 | 2967 | 222104_x_at | 0.3149 | 0.2275 | |
| GSE45670 | GTF2H3 | 2967 | 222104_x_at | 0.3338 | 0.0047 | |
| GSE53622 | GTF2H3 | 2967 | 26632 | 0.6470 | 0.0000 | |
| GSE53624 | GTF2H3 | 2967 | 26632 | 0.5067 | 0.0000 | |
| GSE63941 | GTF2H3 | 2967 | 239346_at | 0.0994 | 0.8339 | |
| GSE77861 | GTF2H3 | 2967 | 222104_x_at | 0.6013 | 0.1198 | |
| GSE97050 | GTF2H3 | 2967 | A_23_P386420 | 0.5958 | 0.1479 | |
| SRP007169 | GTF2H3 | 2967 | RNAseq | 0.6531 | 0.1270 | |
| SRP008496 | GTF2H3 | 2967 | RNAseq | 0.6976 | 0.0011 | |
| SRP064894 | GTF2H3 | 2967 | RNAseq | 0.1277 | 0.6034 | |
| SRP133303 | GTF2H3 | 2967 | RNAseq | 0.5200 | 0.0003 | |
| SRP159526 | GTF2H3 | 2967 | RNAseq | 0.1585 | 0.5314 | |
| SRP193095 | GTF2H3 | 2967 | RNAseq | 0.0518 | 0.6370 | |
| SRP219564 | GTF2H3 | 2967 | RNAseq | -0.1943 | 0.5857 | |
| TCGA | GTF2H3 | 2967 | RNAseq | 0.3098 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GTF2H3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GTF2H3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GTF2H3 | 2967 | 5 | 5 | 20 | |
| GSE20123 | GTF2H3 | 2967 | 5 | 5 | 20 | |
| GSE43470 | GTF2H3 | 2967 | 2 | 1 | 40 | |
| GSE46452 | GTF2H3 | 2967 | 9 | 1 | 49 | |
| GSE47630 | GTF2H3 | 2967 | 9 | 3 | 28 | |
| GSE54993 | GTF2H3 | 2967 | 0 | 5 | 65 | |
| GSE54994 | GTF2H3 | 2967 | 4 | 8 | 41 | |
| GSE60625 | GTF2H3 | 2967 | 0 | 0 | 11 | |
| GSE74703 | GTF2H3 | 2967 | 2 | 0 | 34 | |
| GSE74704 | GTF2H3 | 2967 | 3 | 3 | 14 | |
| TCGA | GTF2H3 | 2967 | 21 | 11 | 64 |
Total number of gains: 60; Total number of losses: 42; Total Number of normals: 386.
Somatic mutations of GTF2H3:
Generating mutation plots.
Highly correlated genes for GTF2H3:
Showing top 20/782 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GTF2H3 | ZNF160 | 0.868617 | 8 | 0 | 8 |
| GTF2H3 | ZNF611 | 0.866569 | 8 | 0 | 8 |
| GTF2H3 | SLC22A3 | 0.855453 | 4 | 0 | 4 |
| GTF2H3 | MZT2B | 0.850475 | 9 | 0 | 9 |
| GTF2H3 | ALMS1 | 0.841847 | 8 | 0 | 8 |
| GTF2H3 | ZNF721 | 0.835669 | 9 | 0 | 9 |
| GTF2H3 | SLC35E1 | 0.825166 | 10 | 0 | 9 |
| GTF2H3 | CMBL | 0.823185 | 4 | 0 | 4 |
| GTF2H3 | CHD1 | 0.818931 | 3 | 0 | 3 |
| GTF2H3 | C9orf64 | 0.81531 | 6 | 0 | 5 |
| GTF2H3 | CYCS | 0.814457 | 3 | 0 | 3 |
| GTF2H3 | HAUS2 | 0.809921 | 11 | 0 | 10 |
| GTF2H3 | OPHN1 | 0.793749 | 3 | 0 | 3 |
| GTF2H3 | SSBP3-AS1 | 0.787327 | 4 | 0 | 4 |
| GTF2H3 | EXOC8 | 0.787 | 3 | 0 | 3 |
| GTF2H3 | UBXN2A | 0.785995 | 6 | 0 | 6 |
| GTF2H3 | TNRC6C-AS1 | 0.782941 | 4 | 0 | 4 |
| GTF2H3 | HPRT1 | 0.780659 | 3 | 0 | 3 |
| GTF2H3 | MRPL32 | 0.777748 | 3 | 0 | 3 |
| GTF2H3 | ZBED6 | 0.773375 | 3 | 0 | 3 |
For details and further investigation, click here
