| Full name: NIMA related kinase 1 | Alias Symbol: NY-REN-55|KIAA1901 | ||
| Type: protein-coding gene | Cytoband: 4q33 | ||
| Entrez ID: 4750 | HGNC ID: HGNC:7744 | Ensembl Gene: ENSG00000137601 | OMIM ID: 604588 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NEK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEK1 | 4750 | 213328_at | -0.2200 | 0.7760 | |
| GSE20347 | NEK1 | 4750 | 213328_at | -0.1687 | 0.1812 | |
| GSE23400 | NEK1 | 4750 | 213328_at | -0.0519 | 0.3877 | |
| GSE26886 | NEK1 | 4750 | 213328_at | -0.5607 | 0.0044 | |
| GSE29001 | NEK1 | 4750 | 213331_s_at | 0.1621 | 0.6976 | |
| GSE38129 | NEK1 | 4750 | 213328_at | -0.4037 | 0.0047 | |
| GSE45670 | NEK1 | 4750 | 213331_s_at | -0.5154 | 0.0185 | |
| GSE53622 | NEK1 | 4750 | 63971 | -0.0694 | 0.4717 | |
| GSE53624 | NEK1 | 4750 | 63971 | -0.0053 | 0.9485 | |
| GSE63941 | NEK1 | 4750 | 213331_s_at | -2.4279 | 0.0011 | |
| GSE77861 | NEK1 | 4750 | 213328_at | 0.2383 | 0.2791 | |
| GSE97050 | NEK1 | 4750 | A_32_P68050 | -0.1208 | 0.6668 | |
| SRP007169 | NEK1 | 4750 | RNAseq | 0.5806 | 0.1882 | |
| SRP008496 | NEK1 | 4750 | RNAseq | 0.9541 | 0.0019 | |
| SRP064894 | NEK1 | 4750 | RNAseq | -0.1448 | 0.5272 | |
| SRP133303 | NEK1 | 4750 | RNAseq | 0.3482 | 0.0425 | |
| SRP159526 | NEK1 | 4750 | RNAseq | 0.4154 | 0.1077 | |
| SRP193095 | NEK1 | 4750 | RNAseq | 0.0126 | 0.9060 | |
| SRP219564 | NEK1 | 4750 | RNAseq | -0.2853 | 0.4859 | |
| TCGA | NEK1 | 4750 | RNAseq | -0.2363 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NEK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEK1 | 4750 | 2 | 11 | 17 | |
| GSE20123 | NEK1 | 4750 | 2 | 11 | 17 | |
| GSE43470 | NEK1 | 4750 | 0 | 13 | 30 | |
| GSE46452 | NEK1 | 4750 | 1 | 36 | 22 | |
| GSE47630 | NEK1 | 4750 | 0 | 22 | 18 | |
| GSE54993 | NEK1 | 4750 | 10 | 0 | 60 | |
| GSE54994 | NEK1 | 4750 | 1 | 13 | 39 | |
| GSE60625 | NEK1 | 4750 | 0 | 0 | 11 | |
| GSE74703 | NEK1 | 4750 | 0 | 11 | 25 | |
| GSE74704 | NEK1 | 4750 | 1 | 5 | 14 | |
| TCGA | NEK1 | 4750 | 11 | 34 | 51 |
Total number of gains: 28; Total number of losses: 156; Total Number of normals: 304.
Somatic mutations of NEK1:
Generating mutation plots.
Highly correlated genes for NEK1:
Showing top 20/304 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEK1 | DNALI1 | 0.760588 | 3 | 0 | 3 |
| NEK1 | BSDC1 | 0.754264 | 3 | 0 | 3 |
| NEK1 | JPX | 0.741545 | 3 | 0 | 3 |
| NEK1 | MAGI1 | 0.735499 | 3 | 0 | 3 |
| NEK1 | ZBED6 | 0.734739 | 5 | 0 | 5 |
| NEK1 | TBRG1 | 0.728237 | 3 | 0 | 3 |
| NEK1 | TMEM181 | 0.725563 | 3 | 0 | 3 |
| NEK1 | ZNF44 | 0.719415 | 3 | 0 | 3 |
| NEK1 | UTP23 | 0.712341 | 3 | 0 | 3 |
| NEK1 | CCDC40 | 0.70967 | 3 | 0 | 3 |
| NEK1 | TOPORS | 0.708058 | 3 | 0 | 3 |
| NEK1 | ARHGAP31 | 0.70726 | 3 | 0 | 3 |
| NEK1 | USP9Y | 0.706039 | 3 | 0 | 3 |
| NEK1 | MTX3 | 0.703524 | 3 | 0 | 3 |
| NEK1 | BDKRB1 | 0.70279 | 3 | 0 | 3 |
| NEK1 | NAALADL1 | 0.699235 | 3 | 0 | 3 |
| NEK1 | CAPN6 | 0.689009 | 3 | 0 | 3 |
| NEK1 | ROR1 | 0.686578 | 3 | 0 | 3 |
| NEK1 | ZBTB4 | 0.685496 | 4 | 0 | 3 |
| NEK1 | NPY1R | 0.685472 | 3 | 0 | 3 |
For details and further investigation, click here
