| Full name: serine/arginine repetitive matrix 2 | Alias Symbol: SRm300|SRL300|KIAA0324|Cwc21 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 23524 | HGNC ID: HGNC:16639 | Ensembl Gene: ENSG00000167978 | OMIM ID: 606032 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SRRM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRRM2 | 23524 | 208610_s_at | -0.3694 | 0.7770 | |
| GSE20347 | SRRM2 | 23524 | 208610_s_at | -0.4070 | 0.0255 | |
| GSE23400 | SRRM2 | 23524 | 207435_s_at | -0.0360 | 0.5528 | |
| GSE26886 | SRRM2 | 23524 | 208610_s_at | -0.1646 | 0.5462 | |
| GSE29001 | SRRM2 | 23524 | 208610_s_at | 0.0869 | 0.8732 | |
| GSE38129 | SRRM2 | 23524 | 208610_s_at | -0.2984 | 0.0959 | |
| GSE45670 | SRRM2 | 23524 | 207435_s_at | 0.1154 | 0.4100 | |
| GSE53622 | SRRM2 | 23524 | 40828 | 0.2562 | 0.0000 | |
| GSE53624 | SRRM2 | 23524 | 40828 | 0.1852 | 0.0002 | |
| GSE63941 | SRRM2 | 23524 | 207435_s_at | 0.5495 | 0.0582 | |
| GSE77861 | SRRM2 | 23524 | 207435_s_at | 0.1969 | 0.4205 | |
| GSE97050 | SRRM2 | 23524 | A_33_P3353343 | 0.5122 | 0.1163 | |
| SRP007169 | SRRM2 | 23524 | RNAseq | 1.1128 | 0.0296 | |
| SRP008496 | SRRM2 | 23524 | RNAseq | 0.9992 | 0.0017 | |
| SRP064894 | SRRM2 | 23524 | RNAseq | -0.4923 | 0.0772 | |
| SRP133303 | SRRM2 | 23524 | RNAseq | -0.1653 | 0.2188 | |
| SRP159526 | SRRM2 | 23524 | RNAseq | -0.5383 | 0.0000 | |
| SRP193095 | SRRM2 | 23524 | RNAseq | 0.2437 | 0.2202 | |
| SRP219564 | SRRM2 | 23524 | RNAseq | -0.1690 | 0.6789 | |
| TCGA | SRRM2 | 23524 | RNAseq | -0.0980 | 0.0027 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SRRM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRRM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRRM2 | 23524 | 5 | 5 | 20 | |
| GSE20123 | SRRM2 | 23524 | 5 | 4 | 21 | |
| GSE43470 | SRRM2 | 23524 | 4 | 7 | 32 | |
| GSE46452 | SRRM2 | 23524 | 38 | 1 | 20 | |
| GSE47630 | SRRM2 | 23524 | 13 | 6 | 21 | |
| GSE54993 | SRRM2 | 23524 | 3 | 5 | 62 | |
| GSE54994 | SRRM2 | 23524 | 5 | 9 | 39 | |
| GSE60625 | SRRM2 | 23524 | 4 | 0 | 7 | |
| GSE74703 | SRRM2 | 23524 | 4 | 5 | 27 | |
| GSE74704 | SRRM2 | 23524 | 3 | 2 | 15 | |
| TCGA | SRRM2 | 23524 | 19 | 13 | 64 |
Total number of gains: 103; Total number of losses: 57; Total Number of normals: 328.
Somatic mutations of SRRM2:
Generating mutation plots.
Highly correlated genes for SRRM2:
Showing top 20/66 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRRM2 | RBFOX2 | 0.657986 | 3 | 0 | 3 |
| SRRM2 | MIDN | 0.626616 | 4 | 0 | 3 |
| SRRM2 | AP2A1 | 0.615457 | 3 | 0 | 3 |
| SRRM2 | TAF15 | 0.606971 | 6 | 0 | 5 |
| SRRM2 | FAM222B | 0.594744 | 4 | 0 | 3 |
| SRRM2 | SH2B2 | 0.589648 | 4 | 0 | 4 |
| SRRM2 | TCF25 | 0.584071 | 5 | 0 | 4 |
| SRRM2 | UBN1 | 0.581056 | 7 | 0 | 4 |
| SRRM2 | RFX1 | 0.576052 | 5 | 0 | 4 |
| SRRM2 | JUND | 0.575506 | 4 | 0 | 3 |
| SRRM2 | GPC1 | 0.575158 | 4 | 0 | 3 |
| SRRM2 | ANKRD36 | 0.57206 | 5 | 0 | 3 |
| SRRM2 | MPHOSPH8 | 0.567477 | 5 | 0 | 3 |
| SRRM2 | CC2D1A | 0.566401 | 6 | 0 | 4 |
| SRRM2 | SNRNP70 | 0.566138 | 8 | 0 | 6 |
| SRRM2 | AAK1 | 0.561569 | 6 | 0 | 4 |
| SRRM2 | DDX42 | 0.557399 | 4 | 0 | 3 |
| SRRM2 | LAMB2 | 0.55651 | 3 | 0 | 3 |
| SRRM2 | ZMYND8 | 0.555613 | 4 | 0 | 3 |
| SRRM2 | ANKRD11 | 0.554496 | 7 | 0 | 3 |
For details and further investigation, click here
