| Full name: mitochondrial antiviral signaling protein | Alias Symbol: VISA|KIAA1271|IPS-1|Cardif | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 57506 | HGNC ID: HGNC:29233 | Ensembl Gene: ENSG00000088888 | OMIM ID: 609676 |
| Drug and gene relationship at DGIdb | |||
MAVS involved pathways:
Expression of MAVS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAVS | 57506 | 226495_at | 0.4916 | 0.1664 | |
| GSE20347 | MAVS | 57506 | 220305_at | -0.2098 | 0.2386 | |
| GSE23400 | MAVS | 57506 | 220305_at | -0.0494 | 0.6183 | |
| GSE26886 | MAVS | 57506 | 226495_at | -0.3718 | 0.0652 | |
| GSE29001 | MAVS | 57506 | 220305_at | -0.1402 | 0.6338 | |
| GSE38129 | MAVS | 57506 | 220305_at | 0.0057 | 0.9829 | |
| GSE45670 | MAVS | 57506 | 226495_at | 0.0935 | 0.5604 | |
| GSE53622 | MAVS | 57506 | 19652 | 0.0377 | 0.5530 | |
| GSE53624 | MAVS | 57506 | 19652 | 0.0491 | 0.3746 | |
| GSE63941 | MAVS | 57506 | 226495_at | 0.2185 | 0.5592 | |
| GSE77861 | MAVS | 57506 | 226495_at | 0.3265 | 0.1728 | |
| GSE97050 | MAVS | 57506 | A_33_P3272527 | -0.1089 | 0.7414 | |
| SRP007169 | MAVS | 57506 | RNAseq | -1.6947 | 0.0000 | |
| SRP008496 | MAVS | 57506 | RNAseq | -1.2638 | 0.0000 | |
| SRP064894 | MAVS | 57506 | RNAseq | -0.0357 | 0.7930 | |
| SRP133303 | MAVS | 57506 | RNAseq | -0.2514 | 0.0452 | |
| SRP159526 | MAVS | 57506 | RNAseq | -0.1268 | 0.4678 | |
| SRP193095 | MAVS | 57506 | RNAseq | -0.1433 | 0.1466 | |
| SRP219564 | MAVS | 57506 | RNAseq | -0.1967 | 0.4361 | |
| TCGA | MAVS | 57506 | RNAseq | -0.1537 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MAVS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAVS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAVS | 57506 | 12 | 3 | 15 | |
| GSE20123 | MAVS | 57506 | 13 | 3 | 14 | |
| GSE43470 | MAVS | 57506 | 10 | 1 | 32 | |
| GSE46452 | MAVS | 57506 | 26 | 1 | 32 | |
| GSE47630 | MAVS | 57506 | 18 | 4 | 18 | |
| GSE54993 | MAVS | 57506 | 2 | 14 | 54 | |
| GSE54994 | MAVS | 57506 | 23 | 3 | 27 | |
| GSE60625 | MAVS | 57506 | 0 | 0 | 11 | |
| GSE74703 | MAVS | 57506 | 9 | 1 | 26 | |
| GSE74704 | MAVS | 57506 | 8 | 1 | 11 | |
| TCGA | MAVS | 57506 | 39 | 11 | 46 |
Total number of gains: 160; Total number of losses: 42; Total Number of normals: 286.
Somatic mutations of MAVS:
Generating mutation plots.
Highly correlated genes for MAVS:
Showing top 20/105 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAVS | SLC41A1 | 0.764183 | 3 | 0 | 3 |
| MAVS | USP4 | 0.748051 | 3 | 0 | 3 |
| MAVS | ZNF273 | 0.734241 | 3 | 0 | 3 |
| MAVS | QSOX2 | 0.722035 | 3 | 0 | 3 |
| MAVS | NCBP2 | 0.711201 | 3 | 0 | 3 |
| MAVS | IFNGR1 | 0.691891 | 3 | 0 | 3 |
| MAVS | VAPB | 0.691554 | 3 | 0 | 3 |
| MAVS | CEBPG | 0.689926 | 3 | 0 | 3 |
| MAVS | NUP43 | 0.689664 | 3 | 0 | 3 |
| MAVS | ZNF260 | 0.689597 | 3 | 0 | 3 |
| MAVS | TBL1X | 0.689279 | 3 | 0 | 3 |
| MAVS | DNAJC7 | 0.68712 | 3 | 0 | 3 |
| MAVS | CASK | 0.683614 | 3 | 0 | 3 |
| MAVS | ANKRD36B | 0.677339 | 3 | 0 | 3 |
| MAVS | ZNF862 | 0.675988 | 3 | 0 | 3 |
| MAVS | TULP4 | 0.672224 | 4 | 0 | 4 |
| MAVS | CHD6 | 0.670015 | 3 | 0 | 3 |
| MAVS | MTHFSD | 0.663799 | 3 | 0 | 3 |
| MAVS | LIG3 | 0.663313 | 3 | 0 | 3 |
| MAVS | PPAT | 0.66175 | 3 | 0 | 3 |
For details and further investigation, click here
