| Full name: ubiquitin specific peptidase 4 | Alias Symbol: Unph | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 7375 | HGNC ID: HGNC:12627 | Ensembl Gene: ENSG00000114316 | OMIM ID: 603486 |
| Drug and gene relationship at DGIdb | |||
Expression of USP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP4 | 7375 | 202682_s_at | -0.2253 | 0.7734 | |
| GSE20347 | USP4 | 7375 | 202682_s_at | -0.6263 | 0.0012 | |
| GSE23400 | USP4 | 7375 | 211800_s_at | -0.5657 | 0.0000 | |
| GSE26886 | USP4 | 7375 | 202682_s_at | -0.4914 | 0.0442 | |
| GSE29001 | USP4 | 7375 | 202682_s_at | -0.6095 | 0.0175 | |
| GSE38129 | USP4 | 7375 | 202682_s_at | -0.6772 | 0.0000 | |
| GSE45670 | USP4 | 7375 | 202682_s_at | -0.3298 | 0.0260 | |
| GSE53622 | USP4 | 7375 | 21851 | -0.7957 | 0.0000 | |
| GSE53624 | USP4 | 7375 | 21851 | -0.6045 | 0.0000 | |
| GSE63941 | USP4 | 7375 | 202682_s_at | -1.8124 | 0.0004 | |
| GSE77861 | USP4 | 7375 | 211800_s_at | -0.7225 | 0.0029 | |
| GSE97050 | USP4 | 7375 | A_24_P291598 | -0.4675 | 0.1709 | |
| SRP007169 | USP4 | 7375 | RNAseq | -1.0306 | 0.0149 | |
| SRP008496 | USP4 | 7375 | RNAseq | -0.8001 | 0.0024 | |
| SRP064894 | USP4 | 7375 | RNAseq | -0.6814 | 0.0000 | |
| SRP133303 | USP4 | 7375 | RNAseq | -0.4338 | 0.0001 | |
| SRP159526 | USP4 | 7375 | RNAseq | -0.7625 | 0.0000 | |
| SRP193095 | USP4 | 7375 | RNAseq | -0.3104 | 0.0196 | |
| SRP219564 | USP4 | 7375 | RNAseq | -0.6305 | 0.0123 | |
| TCGA | USP4 | 7375 | RNAseq | -0.1706 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by USP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP4 | 7375 | 0 | 18 | 12 | |
| GSE20123 | USP4 | 7375 | 0 | 19 | 11 | |
| GSE43470 | USP4 | 7375 | 0 | 18 | 25 | |
| GSE46452 | USP4 | 7375 | 2 | 16 | 41 | |
| GSE47630 | USP4 | 7375 | 1 | 24 | 15 | |
| GSE54993 | USP4 | 7375 | 6 | 2 | 62 | |
| GSE54994 | USP4 | 7375 | 0 | 36 | 17 | |
| GSE60625 | USP4 | 7375 | 5 | 0 | 6 | |
| GSE74703 | USP4 | 7375 | 0 | 14 | 22 | |
| GSE74704 | USP4 | 7375 | 0 | 12 | 8 | |
| TCGA | USP4 | 7375 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of USP4:
Generating mutation plots.
Highly correlated genes for USP4:
Showing top 20/1359 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP4 | ZBED6 | 0.815066 | 3 | 0 | 3 |
| USP4 | FIBIN | 0.795644 | 3 | 0 | 3 |
| USP4 | NPHP3 | 0.77204 | 3 | 0 | 3 |
| USP4 | LRRN4CL | 0.769028 | 3 | 0 | 3 |
| USP4 | RAB7B | 0.768286 | 3 | 0 | 3 |
| USP4 | MTRF1 | 0.765155 | 3 | 0 | 3 |
| USP4 | SLC35B3 | 0.761295 | 3 | 0 | 3 |
| USP4 | ERGIC1 | 0.760569 | 3 | 0 | 3 |
| USP4 | ZNF578 | 0.752489 | 3 | 0 | 3 |
| USP4 | HERC4 | 0.750569 | 3 | 0 | 3 |
| USP4 | CLEC3B | 0.748954 | 3 | 0 | 3 |
| USP4 | MAVS | 0.748051 | 3 | 0 | 3 |
| USP4 | MRC2 | 0.746059 | 3 | 0 | 3 |
| USP4 | TPCN1 | 0.734428 | 10 | 0 | 10 |
| USP4 | CWC15 | 0.733527 | 3 | 0 | 3 |
| USP4 | LRRK2 | 0.733027 | 7 | 0 | 7 |
| USP4 | FUT11 | 0.725405 | 3 | 0 | 3 |
| USP4 | MEIS1 | 0.723645 | 10 | 0 | 10 |
| USP4 | AK3 | 0.722601 | 5 | 0 | 5 |
| USP4 | UBE2E2 | 0.720932 | 4 | 0 | 4 |
For details and further investigation, click here
