IFNGR1

 

Full name: interferon gamma receptor 1 Alias Symbol: CD119
Type: protein-coding gene Cytoband: 6q23.3
Entrez ID: 3459 HGNC ID: HGNC:5439 Ensembl Gene: ENSG00000027697 OMIM ID: 107470
Drug and gene relationship at DGIdb
Screen Evidence:

 

IFNGR1 involved pathways:

KEGG pathway Description View
hsa04066HIF-1 signaling pathway
hsa04380Osteoclast differentiation
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05132Salmonella infection
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05321Inflammatory bowel disease (IBD)

 

Expression of IFNGR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IFNGR1 3459 202727_s_at 0.9283 0.1241
GSE20347 IFNGR1 3459 202727_s_at 0.6643 0.0033
GSE23400 IFNGR1 3459 202727_s_at 0.9609 0.0000
GSE26886 IFNGR1 3459 202727_s_at 1.1238 0.0003
GSE29001 IFNGR1 3459 202727_s_at 0.8074 0.0058
GSE38129 IFNGR1 3459 202727_s_at 0.6302 0.0005
GSE45670 IFNGR1 3459 202727_s_at 0.7826 0.0002
GSE53622 IFNGR1 3459 58757 0.8137 0.0000
GSE53624 IFNGR1 3459 58757 0.7052 0.0000
GSE63941 IFNGR1 3459 202727_s_at -0.2992 0.7429
GSE77861 IFNGR1 3459 202727_s_at 1.1964 0.0027
GSE97050 IFNGR1 3459 A_23_P8281 1.0665 0.0750
SRP007169 IFNGR1 3459 RNAseq 0.3116 0.4215
SRP008496 IFNGR1 3459 RNAseq 0.3093 0.2969
SRP064894 IFNGR1 3459 RNAseq 0.5935 0.0058
SRP133303 IFNGR1 3459 RNAseq 1.0482 0.0002
SRP159526 IFNGR1 3459 RNAseq 0.3104 0.4488
SRP193095 IFNGR1 3459 RNAseq 0.6678 0.0000
SRP219564 IFNGR1 3459 RNAseq 0.2845 0.4382
TCGA IFNGR1 3459 RNAseq 0.1648 0.0019

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by IFNGR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IFNGR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IFNGR1 3459 4 4 22
GSE20123 IFNGR1 3459 3 3 24
GSE43470 IFNGR1 3459 5 0 38
GSE46452 IFNGR1 3459 3 10 46
GSE47630 IFNGR1 3459 9 4 27
GSE54993 IFNGR1 3459 3 2 65
GSE54994 IFNGR1 3459 8 8 37
GSE60625 IFNGR1 3459 0 1 10
GSE74703 IFNGR1 3459 4 0 32
GSE74704 IFNGR1 3459 1 1 18
TCGA IFNGR1 3459 12 17 67

Total number of gains: 52; Total number of losses: 50; Total Number of normals: 386.  

 

Somatic mutations of IFNGR1:

 

Generating mutation plots.

 

Highly correlated genes for IFNGR1:

 

Showing top 20/1949 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IFNGR1PPP1R350.801075303
IFNGR1LRRC8C0.778227303
IFNGR1THOP10.766887303
IFNGR1UBR10.755071303
IFNGR1CCDC1270.754446303
IFNGR1PDPR0.75119303
IFNGR1KTI120.740226303
IFNGR1CCM20.739341707
IFNGR1FAM89A0.737354303
IFNGR1TMEM1380.737099706
IFNGR1PHOSPHO20.732113303
IFNGR1UHMK10.731276606
IFNGR1MET0.72711710010
IFNGR1RILPL20.726847404
IFNGR1DPY19L40.725888909
IFNGR1ANAPC40.724989303
IFNGR1C12orf750.724896707
IFNGR1USP210.724128303
IFNGR1PSMB20.723075908
IFNGR1PDE7A0.722709706

For details and further investigation, click here