| Full name: chromodomain helicase DNA binding protein 6 | Alias Symbol: KIAA1335|FLJ22369|dJ620E11.1|CHD5|RIGB | ||
| Type: protein-coding gene | Cytoband: 20q12 | ||
| Entrez ID: 84181 | HGNC ID: HGNC:19057 | Ensembl Gene: ENSG00000124177 | OMIM ID: 616114 |
| Drug and gene relationship at DGIdb | |||
Expression of CHD6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHD6 | 84181 | 225031_at | 0.5225 | 0.1393 | |
| GSE26886 | CHD6 | 84181 | 225031_at | 0.1945 | 0.5523 | |
| GSE45670 | CHD6 | 84181 | 225031_at | 0.2602 | 0.1255 | |
| GSE53622 | CHD6 | 84181 | 42240 | 0.3721 | 0.0000 | |
| GSE53624 | CHD6 | 84181 | 2098 | 0.0688 | 0.3621 | |
| GSE63941 | CHD6 | 84181 | 225031_at | -0.2736 | 0.5532 | |
| GSE77861 | CHD6 | 84181 | 225031_at | 0.2341 | 0.2903 | |
| GSE97050 | CHD6 | 84181 | A_23_P102607 | -0.0382 | 0.8905 | |
| SRP007169 | CHD6 | 84181 | RNAseq | 1.3781 | 0.0000 | |
| SRP008496 | CHD6 | 84181 | RNAseq | 1.2401 | 0.0000 | |
| SRP064894 | CHD6 | 84181 | RNAseq | 0.0228 | 0.9081 | |
| SRP133303 | CHD6 | 84181 | RNAseq | 0.1894 | 0.1486 | |
| SRP159526 | CHD6 | 84181 | RNAseq | 0.4552 | 0.1322 | |
| SRP193095 | CHD6 | 84181 | RNAseq | 0.4298 | 0.0002 | |
| SRP219564 | CHD6 | 84181 | RNAseq | 0.0297 | 0.9068 | |
| TCGA | CHD6 | 84181 | RNAseq | -0.0291 | 0.5661 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CHD6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHD6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHD6 | 84181 | 13 | 1 | 16 | |
| GSE20123 | CHD6 | 84181 | 13 | 1 | 16 | |
| GSE43470 | CHD6 | 84181 | 13 | 1 | 29 | |
| GSE46452 | CHD6 | 84181 | 29 | 0 | 30 | |
| GSE47630 | CHD6 | 84181 | 24 | 0 | 16 | |
| GSE54993 | CHD6 | 84181 | 0 | 17 | 53 | |
| GSE54994 | CHD6 | 84181 | 24 | 0 | 29 | |
| GSE60625 | CHD6 | 84181 | 0 | 0 | 11 | |
| GSE74703 | CHD6 | 84181 | 10 | 1 | 25 | |
| GSE74704 | CHD6 | 84181 | 9 | 0 | 11 | |
| TCGA | CHD6 | 84181 | 47 | 4 | 45 |
Total number of gains: 182; Total number of losses: 25; Total Number of normals: 281.
Somatic mutations of CHD6:
Generating mutation plots.
Highly correlated genes for CHD6:
Showing top 20/394 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHD6 | UPF1 | 0.751242 | 3 | 0 | 3 |
| CHD6 | CCDC93 | 0.734762 | 4 | 0 | 3 |
| CHD6 | PCID2 | 0.730825 | 3 | 0 | 3 |
| CHD6 | PANK4 | 0.728707 | 3 | 0 | 3 |
| CHD6 | CBLB | 0.727112 | 3 | 0 | 3 |
| CHD6 | PIK3R3 | 0.721374 | 3 | 0 | 3 |
| CHD6 | TMTC4 | 0.713131 | 4 | 0 | 4 |
| CHD6 | RRP1B | 0.706055 | 3 | 0 | 3 |
| CHD6 | MRPS9 | 0.700919 | 3 | 0 | 3 |
| CHD6 | ASXL1 | 0.697339 | 5 | 0 | 4 |
| CHD6 | ZNF550 | 0.695576 | 3 | 0 | 3 |
| CHD6 | KANSL3 | 0.693678 | 5 | 0 | 5 |
| CHD6 | RCOR3 | 0.692962 | 3 | 0 | 3 |
| CHD6 | FN3KRP | 0.682849 | 3 | 0 | 3 |
| CHD6 | ZNF260 | 0.67762 | 4 | 0 | 3 |
| CHD6 | ALMS1 | 0.677461 | 5 | 0 | 4 |
| CHD6 | ATR | 0.677407 | 4 | 0 | 4 |
| CHD6 | CARS2 | 0.675794 | 3 | 0 | 3 |
| CHD6 | GDPD1 | 0.67151 | 3 | 0 | 3 |
| CHD6 | KBTBD6 | 0.671199 | 4 | 0 | 3 |
For details and further investigation, click here
