| Full name: DNA ligase 3 | Alias Symbol: LIG3alpha | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 3980 | HGNC ID: HGNC:6600 | Ensembl Gene: ENSG00000005156 | OMIM ID: 600940 |
| Drug and gene relationship at DGIdb | |||
Expression of LIG3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIG3 | 3980 | 204123_at | 0.3711 | 0.2327 | |
| GSE20347 | LIG3 | 3980 | 204123_at | 0.4708 | 0.0100 | |
| GSE23400 | LIG3 | 3980 | 204123_at | 0.2162 | 0.0000 | |
| GSE26886 | LIG3 | 3980 | 1554599_x_at | 0.5885 | 0.0067 | |
| GSE29001 | LIG3 | 3980 | 204123_at | 0.2270 | 0.1932 | |
| GSE38129 | LIG3 | 3980 | 204123_at | 0.6173 | 0.0000 | |
| GSE45670 | LIG3 | 3980 | 1554599_x_at | -0.0314 | 0.9017 | |
| GSE53622 | LIG3 | 3980 | 116018 | 0.1379 | 0.0465 | |
| GSE53624 | LIG3 | 3980 | 116018 | 0.3252 | 0.0000 | |
| GSE63941 | LIG3 | 3980 | 1554599_x_at | 0.9376 | 0.0400 | |
| GSE77861 | LIG3 | 3980 | 1554597_at | 0.3934 | 0.0657 | |
| GSE97050 | LIG3 | 3980 | A_23_P501134 | -0.1033 | 0.7344 | |
| SRP007169 | LIG3 | 3980 | RNAseq | 0.5127 | 0.1310 | |
| SRP008496 | LIG3 | 3980 | RNAseq | 0.3691 | 0.1196 | |
| SRP064894 | LIG3 | 3980 | RNAseq | 0.2147 | 0.2940 | |
| SRP133303 | LIG3 | 3980 | RNAseq | 0.1011 | 0.5558 | |
| SRP159526 | LIG3 | 3980 | RNAseq | 0.7817 | 0.0012 | |
| SRP193095 | LIG3 | 3980 | RNAseq | 0.2422 | 0.0134 | |
| SRP219564 | LIG3 | 3980 | RNAseq | 0.1118 | 0.7396 | |
| TCGA | LIG3 | 3980 | RNAseq | 0.1212 | 0.0509 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LIG3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIG3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIG3 | 3980 | 5 | 1 | 24 | |
| GSE20123 | LIG3 | 3980 | 5 | 1 | 24 | |
| GSE43470 | LIG3 | 3980 | 1 | 2 | 40 | |
| GSE46452 | LIG3 | 3980 | 34 | 0 | 25 | |
| GSE47630 | LIG3 | 3980 | 7 | 1 | 32 | |
| GSE54993 | LIG3 | 3980 | 3 | 3 | 64 | |
| GSE54994 | LIG3 | 3980 | 8 | 6 | 39 | |
| GSE60625 | LIG3 | 3980 | 4 | 0 | 7 | |
| GSE74703 | LIG3 | 3980 | 1 | 1 | 34 | |
| GSE74704 | LIG3 | 3980 | 3 | 1 | 16 | |
| TCGA | LIG3 | 3980 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of LIG3:
Generating mutation plots.
Highly correlated genes for LIG3:
Showing top 20/1045 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIG3 | DEDD | 0.834368 | 3 | 0 | 3 |
| LIG3 | SENP6 | 0.813529 | 3 | 0 | 3 |
| LIG3 | THEM4 | 0.801141 | 3 | 0 | 3 |
| LIG3 | DZIP3 | 0.775023 | 3 | 0 | 3 |
| LIG3 | ALKBH6 | 0.761573 | 3 | 0 | 3 |
| LIG3 | PARM1 | 0.760668 | 3 | 0 | 3 |
| LIG3 | COMMD7 | 0.753359 | 3 | 0 | 3 |
| LIG3 | SGCE | 0.748049 | 4 | 0 | 4 |
| LIG3 | KCNE3 | 0.747217 | 3 | 0 | 3 |
| LIG3 | BOD1 | 0.747042 | 3 | 0 | 3 |
| LIG3 | ARNT | 0.74332 | 3 | 0 | 3 |
| LIG3 | CTXN1 | 0.73279 | 3 | 0 | 3 |
| LIG3 | MRPL38 | 0.729704 | 3 | 0 | 3 |
| LIG3 | PET117 | 0.727898 | 3 | 0 | 3 |
| LIG3 | DNAJC19 | 0.718548 | 3 | 0 | 3 |
| LIG3 | SFSWAP | 0.718324 | 3 | 0 | 3 |
| LIG3 | PRRC2C | 0.715062 | 3 | 0 | 3 |
| LIG3 | SLC25A37 | 0.714517 | 3 | 0 | 3 |
| LIG3 | MED13 | 0.714353 | 4 | 0 | 4 |
| LIG3 | SLC7A6 | 0.713621 | 4 | 0 | 3 |
For details and further investigation, click here
