| Full name: methenyltetrahydrofolate synthetase domain containing | Alias Symbol: FLJ12998 | ||
| Type: protein-coding gene | Cytoband: 16q24.1 | ||
| Entrez ID: 64779 | HGNC ID: HGNC:25778 | Ensembl Gene: ENSG00000103248 | OMIM ID: 616820 |
| Drug and gene relationship at DGIdb | |||
Expression of MTHFSD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTHFSD | 64779 | 218879_s_at | 0.6682 | 0.1504 | |
| GSE20347 | MTHFSD | 64779 | 218879_s_at | 0.1167 | 0.2573 | |
| GSE23400 | MTHFSD | 64779 | 218879_s_at | 0.1301 | 0.0027 | |
| GSE26886 | MTHFSD | 64779 | 222769_at | -0.2799 | 0.0456 | |
| GSE29001 | MTHFSD | 64779 | 218879_s_at | 0.1466 | 0.5442 | |
| GSE38129 | MTHFSD | 64779 | 218879_s_at | 0.1603 | 0.0860 | |
| GSE45670 | MTHFSD | 64779 | 222769_at | 0.2085 | 0.0324 | |
| GSE53622 | MTHFSD | 64779 | 2536 | 0.2756 | 0.0024 | |
| GSE53624 | MTHFSD | 64779 | 93663 | 0.3409 | 0.0000 | |
| GSE63941 | MTHFSD | 64779 | 218879_s_at | 0.9052 | 0.0260 | |
| GSE77861 | MTHFSD | 64779 | 218879_s_at | 0.0432 | 0.8101 | |
| GSE97050 | MTHFSD | 64779 | A_23_P100455 | 0.2118 | 0.3130 | |
| SRP007169 | MTHFSD | 64779 | RNAseq | 0.4411 | 0.2914 | |
| SRP008496 | MTHFSD | 64779 | RNAseq | 0.3730 | 0.2244 | |
| SRP064894 | MTHFSD | 64779 | RNAseq | 0.2651 | 0.0907 | |
| SRP133303 | MTHFSD | 64779 | RNAseq | 0.4974 | 0.0661 | |
| SRP159526 | MTHFSD | 64779 | RNAseq | -0.0041 | 0.9834 | |
| SRP193095 | MTHFSD | 64779 | RNAseq | 0.2010 | 0.0164 | |
| SRP219564 | MTHFSD | 64779 | RNAseq | -0.0398 | 0.8701 | |
| TCGA | MTHFSD | 64779 | RNAseq | 0.0606 | 0.3184 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MTHFSD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTHFSD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTHFSD | 64779 | 5 | 2 | 23 | |
| GSE20123 | MTHFSD | 64779 | 5 | 2 | 23 | |
| GSE43470 | MTHFSD | 64779 | 2 | 12 | 29 | |
| GSE46452 | MTHFSD | 64779 | 38 | 1 | 20 | |
| GSE47630 | MTHFSD | 64779 | 11 | 9 | 20 | |
| GSE54993 | MTHFSD | 64779 | 3 | 4 | 63 | |
| GSE54994 | MTHFSD | 64779 | 9 | 11 | 33 | |
| GSE60625 | MTHFSD | 64779 | 4 | 0 | 7 | |
| GSE74703 | MTHFSD | 64779 | 1 | 9 | 26 | |
| GSE74704 | MTHFSD | 64779 | 3 | 2 | 15 | |
| TCGA | MTHFSD | 64779 | 27 | 15 | 54 |
Total number of gains: 108; Total number of losses: 67; Total Number of normals: 313.
Somatic mutations of MTHFSD:
Generating mutation plots.
Highly correlated genes for MTHFSD:
Showing top 20/235 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTHFSD | ZFYVE27 | 0.764117 | 3 | 0 | 3 |
| MTHFSD | CRTC2 | 0.759983 | 3 | 0 | 3 |
| MTHFSD | ARFRP1 | 0.753513 | 3 | 0 | 3 |
| MTHFSD | RALGAPA2 | 0.750369 | 3 | 0 | 3 |
| MTHFSD | ALMS1 | 0.750238 | 3 | 0 | 3 |
| MTHFSD | GZF1 | 0.746619 | 3 | 0 | 3 |
| MTHFSD | UBQLN4 | 0.746352 | 3 | 0 | 3 |
| MTHFSD | BSDC1 | 0.729786 | 3 | 0 | 3 |
| MTHFSD | CHD1L | 0.723217 | 3 | 0 | 3 |
| MTHFSD | ZNF740 | 0.714611 | 3 | 0 | 3 |
| MTHFSD | PPP1R37 | 0.713782 | 3 | 0 | 3 |
| MTHFSD | MRPL14 | 0.712747 | 3 | 0 | 3 |
| MTHFSD | MSTO1 | 0.701753 | 3 | 0 | 3 |
| MTHFSD | BAG6 | 0.699169 | 4 | 0 | 4 |
| MTHFSD | TMCO4 | 0.695082 | 3 | 0 | 3 |
| MTHFSD | ATP13A1 | 0.690497 | 3 | 0 | 3 |
| MTHFSD | CPLX1 | 0.688764 | 3 | 0 | 3 |
| MTHFSD | ETV6 | 0.687282 | 3 | 0 | 3 |
| MTHFSD | CST1 | 0.68481 | 3 | 0 | 3 |
| MTHFSD | ZNF787 | 0.684117 | 3 | 0 | 3 |
For details and further investigation, click here
