| Full name: mindbomb E3 ubiquitin protein ligase 2 | Alias Symbol: skeletrophin|ZZZ5|FLJ39787 | ||
| Type: protein-coding gene | Cytoband: 1p36.33 | ||
| Entrez ID: 142678 | HGNC ID: HGNC:30577 | Ensembl Gene: ENSG00000197530 | OMIM ID: 611141 |
| Drug and gene relationship at DGIdb | |||
Expression of MIB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MIB2 | 142678 | 228261_at | 0.7425 | 0.3287 | |
| GSE26886 | MIB2 | 142678 | 228261_at | 1.4195 | 0.0034 | |
| GSE45670 | MIB2 | 142678 | 228261_at | 0.4002 | 0.1175 | |
| GSE53622 | MIB2 | 142678 | 73876 | 0.0282 | 0.6194 | |
| GSE53624 | MIB2 | 142678 | 73876 | 0.3422 | 0.0000 | |
| GSE63941 | MIB2 | 142678 | 228261_at | 1.3014 | 0.2007 | |
| GSE77861 | MIB2 | 142678 | 228261_at | 0.2951 | 0.3091 | |
| GSE97050 | MIB2 | 142678 | A_33_P3308903 | 0.5270 | 0.2650 | |
| SRP007169 | MIB2 | 142678 | RNAseq | -1.1631 | 0.0248 | |
| SRP008496 | MIB2 | 142678 | RNAseq | -1.0211 | 0.0074 | |
| SRP064894 | MIB2 | 142678 | RNAseq | 0.4488 | 0.0655 | |
| SRP133303 | MIB2 | 142678 | RNAseq | -0.2049 | 0.3702 | |
| SRP159526 | MIB2 | 142678 | RNAseq | -0.0909 | 0.7655 | |
| SRP193095 | MIB2 | 142678 | RNAseq | 0.1555 | 0.1792 | |
| SRP219564 | MIB2 | 142678 | RNAseq | -0.1047 | 0.7569 | |
| TCGA | MIB2 | 142678 | RNAseq | 0.1201 | 0.0715 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by MIB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MIB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MIB2 | 142678 | 3 | 7 | 20 | |
| GSE20123 | MIB2 | 142678 | 3 | 6 | 21 | |
| GSE43470 | MIB2 | 142678 | 3 | 5 | 35 | |
| GSE46452 | MIB2 | 142678 | 7 | 1 | 51 | |
| GSE47630 | MIB2 | 142678 | 8 | 4 | 28 | |
| GSE54993 | MIB2 | 142678 | 2 | 2 | 66 | |
| GSE54994 | MIB2 | 142678 | 15 | 2 | 36 | |
| GSE60625 | MIB2 | 142678 | 0 | 0 | 11 | |
| GSE74703 | MIB2 | 142678 | 3 | 3 | 30 | |
| GSE74704 | MIB2 | 142678 | 3 | 0 | 17 | |
| TCGA | MIB2 | 142678 | 14 | 20 | 62 |
Total number of gains: 61; Total number of losses: 50; Total Number of normals: 377.
Somatic mutations of MIB2:
Generating mutation plots.
Highly correlated genes for MIB2:
Showing top 20/176 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MIB2 | NTHL1 | 0.799242 | 3 | 0 | 3 |
| MIB2 | ZRANB3 | 0.774897 | 3 | 0 | 3 |
| MIB2 | C7orf26 | 0.765391 | 3 | 0 | 3 |
| MIB2 | ZNF639 | 0.755931 | 3 | 0 | 3 |
| MIB2 | SURF2 | 0.749717 | 3 | 0 | 3 |
| MIB2 | PGS1 | 0.728689 | 3 | 0 | 3 |
| MIB2 | C14orf93 | 0.718769 | 3 | 0 | 3 |
| MIB2 | TONSL | 0.717668 | 3 | 0 | 3 |
| MIB2 | C1orf109 | 0.708937 | 3 | 0 | 3 |
| MIB2 | CHP2 | 0.707108 | 3 | 0 | 3 |
| MIB2 | C12orf10 | 0.701278 | 3 | 0 | 3 |
| MIB2 | CXorf56 | 0.69249 | 3 | 0 | 3 |
| MIB2 | EXOSC1 | 0.686775 | 3 | 0 | 3 |
| MIB2 | C19orf53 | 0.681969 | 4 | 0 | 4 |
| MIB2 | ZNF511 | 0.670026 | 4 | 0 | 3 |
| MIB2 | EFNB1 | 0.666385 | 4 | 0 | 4 |
| MIB2 | DCBLD2 | 0.665957 | 3 | 0 | 3 |
| MIB2 | FAM189B | 0.662529 | 4 | 0 | 3 |
| MIB2 | LAMTOR2 | 0.661392 | 3 | 0 | 3 |
| MIB2 | SLC27A5 | 0.660165 | 3 | 0 | 3 |
For details and further investigation, click here
