C19orf53

 

Full name: chromosome 19 open reading frame 53 Alias Symbol: HSPC023|LYDG10
Type: protein-coding gene Cytoband: 19p13.13
Entrez ID: 28974 HGNC ID: HGNC:24991 Ensembl Gene: ENSG00000104979 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of C19orf53:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 C19orf53 28974 217926_at 0.3452 0.4767
GSE20347 C19orf53 28974 217926_at 0.0629 0.6617
GSE23400 C19orf53 28974 217926_at 0.3343 0.0000
GSE26886 C19orf53 28974 217926_at 0.6215 0.0004
GSE29001 C19orf53 28974 217926_at 0.1604 0.6769
GSE38129 C19orf53 28974 217926_at 0.1631 0.1092
GSE45670 C19orf53 28974 217926_at 0.1387 0.3416
GSE63941 C19orf53 28974 217926_at 0.3211 0.2721
GSE77861 C19orf53 28974 217926_at 0.3847 0.0751
GSE97050 C19orf53 28974 A_33_P3409347 -0.1702 0.5172
SRP007169 C19orf53 28974 RNAseq 0.7331 0.2296
SRP064894 C19orf53 28974 RNAseq 0.8659 0.0227
SRP133303 C19orf53 28974 RNAseq 0.3759 0.0187
SRP159526 C19orf53 28974 RNAseq 0.1502 0.3788
SRP193095 C19orf53 28974 RNAseq -0.0295 0.8184
SRP219564 C19orf53 28974 RNAseq 0.3808 0.2520
TCGA C19orf53 28974 RNAseq 0.2034 0.0014

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by C19orf53 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of C19orf53:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 C19orf53 28974 4 2 24
GSE20123 C19orf53 28974 3 1 26
GSE43470 C19orf53 28974 2 6 35
GSE46452 C19orf53 28974 47 1 11
GSE47630 C19orf53 28974 4 7 29
GSE54993 C19orf53 28974 15 4 51
GSE54994 C19orf53 28974 6 13 34
GSE60625 C19orf53 28974 9 0 2
GSE74703 C19orf53 28974 2 4 30
GSE74704 C19orf53 28974 0 1 19
TCGA C19orf53 28974 21 11 64

Total number of gains: 113; Total number of losses: 50; Total Number of normals: 325.  

 

Somatic mutations of C19orf53:

 

Generating mutation plots.

 

Highly correlated genes for C19orf53:

 

Showing top 20/251 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
C19orf53TMUB10.789671303
C19orf53CHP20.775077303
C19orf53PYGO20.771818303
C19orf53STK110.758399303
C19orf53ARHGAP210.746141303
C19orf53NAT140.741961404
C19orf53ZDHHC80.740698303
C19orf53HSD17B140.739319303
C19orf53IER5L0.735161303
C19orf53PRR150.733433504
C19orf53OSGIN10.732313303
C19orf53ZNF5110.72885505
C19orf53ATG4D0.727099303
C19orf53JAKMIP30.722268303
C19orf53ADRA2C0.72211303
C19orf53PINX10.718163303
C19orf53BMF0.717403303
C19orf53C7orf260.715188303
C19orf53TRIM110.71507303
C19orf53TNNC20.711792303

For details and further investigation, click here