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Multi-Omics Database of ESCC

 

LAMTOR2

 

Full name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Alias Symbol: MAPBPIP|MAPKSP1AP|p14|ENDAP|Ragulator2
Type: protein-coding gene Cytoband: 1q22
Entrez ID: 28956 HGNC ID: HGNC:29796 Ensembl Gene: ENSG00000116586 OMIM ID: 610389
Drug and gene relationship at DGIdb
Screen Evidence:

 

LAMTOR2 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway

 

Expression of LAMTOR2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LAMTOR2 28956 218291_at 0.1683 0.5675
GSE20347 LAMTOR2 28956 218291_at -0.4655 0.0011
GSE23400 LAMTOR2 28956 218291_at -0.0337 0.5860
GSE26886 LAMTOR2 28956 218291_at 0.4737 0.0137
GSE29001 LAMTOR2 28956 218291_at -0.0794 0.7700
GSE38129 LAMTOR2 28956 218291_at -0.1547 0.3174
GSE45670 LAMTOR2 28956 218291_at 0.0055 0.9678
GSE53622 LAMTOR2 28956 54734 -0.1002 0.0560
GSE53624 LAMTOR2 28956 54734 0.0071 0.9118
GSE63941 LAMTOR2 28956 218291_at -0.2554 0.4158
GSE77861 LAMTOR2 28956 218291_at -0.0764 0.7649
GSE97050 LAMTOR2 28956 A_33_P3246068 0.0217 0.9323
SRP007169 LAMTOR2 28956 RNAseq -1.2003 0.0003
SRP008496 LAMTOR2 28956 RNAseq -0.6867 0.0024
SRP064894 LAMTOR2 28956 RNAseq 0.7455 0.0548
SRP133303 LAMTOR2 28956 RNAseq 0.1922 0.1935
SRP159526 LAMTOR2 28956 RNAseq -0.0164 0.9221
SRP193095 LAMTOR2 28956 RNAseq -0.2029 0.0963
SRP219564 LAMTOR2 28956 RNAseq -0.0482 0.8860

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by LAMTOR2 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of LAMTOR2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LAMTOR2 28956 14 0 16
GSE20123 LAMTOR2 28956 13 0 17
GSE43470 LAMTOR2 28956 7 2 34
GSE46452 LAMTOR2 28956 2 1 56
GSE47630 LAMTOR2 28956 14 0 26
GSE54993 LAMTOR2 28956 0 5 65
GSE54994 LAMTOR2 28956 16 0 37
GSE60625 LAMTOR2 28956 0 0 11
GSE74703 LAMTOR2 28956 7 2 27
GSE74704 LAMTOR2 28956 6 0 14
TCGA LAMTOR2 28956 38 2 56

Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.  

 

Somatic mutations of LAMTOR2:

 

Generating mutation plots.

 

Highly correlated genes for LAMTOR2:

 

Showing top 20/100 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LAMTOR2AIFM30.752097303
LAMTOR2ZC3H100.74989303
LAMTOR2KLHL350.747694303
LAMTOR2C19orf810.738207303
LAMTOR2STK32C0.735989303
LAMTOR2JSRP10.733658303
LAMTOR2RAG20.719959303
LAMTOR2WDR600.715114303
LAMTOR2CLN30.708203303
LAMTOR2FUT100.707562303
LAMTOR2IL17RE0.705174303
LAMTOR2ETV30.70442303
LAMTOR2ZNF7770.698397504
LAMTOR2WRAP730.695208303
LAMTOR2REG3A0.694623303
LAMTOR2STAC30.687653303
LAMTOR2IRAK10.687507403
LAMTOR2SDCCAG80.682146303
LAMTOR2ADPRHL20.679555303
LAMTOR2CCDC1420.679131303

For details and further investigation, click here