| Full name: family with sequence similarity 189 member B | Alias Symbol: cote1 | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 10712 | HGNC ID: HGNC:1233 | Ensembl Gene: ENSG00000160767 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of FAM189B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FAM189B | 10712 | 203550_s_at | 0.8264 | 0.1604 | |
| GSE20347 | FAM189B | 10712 | 203550_s_at | 0.4755 | 0.0000 | |
| GSE23400 | FAM189B | 10712 | 203550_s_at | 0.2734 | 0.0000 | |
| GSE26886 | FAM189B | 10712 | 203550_s_at | 0.9300 | 0.0000 | |
| GSE29001 | FAM189B | 10712 | 203550_s_at | 0.3852 | 0.0480 | |
| GSE38129 | FAM189B | 10712 | 203550_s_at | 0.4686 | 0.0000 | |
| GSE45670 | FAM189B | 10712 | 203550_s_at | 0.4428 | 0.0004 | |
| GSE53622 | FAM189B | 10712 | 132665 | 0.4298 | 0.0000 | |
| GSE53624 | FAM189B | 10712 | 132665 | 0.5238 | 0.0000 | |
| GSE63941 | FAM189B | 10712 | 203550_s_at | -0.0125 | 0.9753 | |
| GSE77861 | FAM189B | 10712 | 203550_s_at | 0.4892 | 0.0469 | |
| GSE97050 | FAM189B | 10712 | A_33_P3359160 | 0.1629 | 0.4825 | |
| SRP007169 | FAM189B | 10712 | RNAseq | 0.1295 | 0.7237 | |
| SRP008496 | FAM189B | 10712 | RNAseq | 0.3004 | 0.2125 | |
| SRP064894 | FAM189B | 10712 | RNAseq | 0.9456 | 0.0000 | |
| SRP133303 | FAM189B | 10712 | RNAseq | 0.3919 | 0.0356 | |
| SRP159526 | FAM189B | 10712 | RNAseq | 1.0257 | 0.0000 | |
| SRP193095 | FAM189B | 10712 | RNAseq | 0.6490 | 0.0000 | |
| SRP219564 | FAM189B | 10712 | RNAseq | 0.7554 | 0.1434 | |
| TCGA | FAM189B | 10712 | RNAseq | 0.1619 | 0.0018 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FAM189B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FAM189B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FAM189B | 10712 | 14 | 0 | 16 | |
| GSE20123 | FAM189B | 10712 | 13 | 0 | 17 | |
| GSE43470 | FAM189B | 10712 | 7 | 3 | 33 | |
| GSE46452 | FAM189B | 10712 | 2 | 1 | 56 | |
| GSE47630 | FAM189B | 10712 | 14 | 0 | 26 | |
| GSE54993 | FAM189B | 10712 | 0 | 4 | 66 | |
| GSE54994 | FAM189B | 10712 | 16 | 0 | 37 | |
| GSE60625 | FAM189B | 10712 | 0 | 0 | 11 | |
| GSE74703 | FAM189B | 10712 | 7 | 2 | 27 | |
| GSE74704 | FAM189B | 10712 | 6 | 0 | 14 | |
| TCGA | FAM189B | 10712 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.
Somatic mutations of FAM189B:
Generating mutation plots.
Highly correlated genes for FAM189B:
Showing top 20/596 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FAM189B | LIPE | 0.802272 | 3 | 0 | 3 |
| FAM189B | EML6 | 0.775361 | 3 | 0 | 3 |
| FAM189B | ATXN7L2 | 0.744882 | 3 | 0 | 3 |
| FAM189B | HOXC9 | 0.742386 | 5 | 0 | 5 |
| FAM189B | SLC34A1 | 0.733693 | 3 | 0 | 3 |
| FAM189B | ZNF576 | 0.72706 | 3 | 0 | 3 |
| FAM189B | ETV3 | 0.727026 | 4 | 0 | 4 |
| FAM189B | TNFAIP8L1 | 0.721838 | 6 | 0 | 5 |
| FAM189B | ARHGAP23 | 0.719285 | 3 | 0 | 3 |
| FAM189B | SMPD4 | 0.718419 | 3 | 0 | 3 |
| FAM189B | YDJC | 0.708381 | 6 | 0 | 6 |
| FAM189B | ZNF524 | 0.70293 | 3 | 0 | 3 |
| FAM189B | ZNF526 | 0.698887 | 5 | 0 | 4 |
| FAM189B | FBRSL1 | 0.697838 | 6 | 0 | 5 |
| FAM189B | TOX2 | 0.697727 | 3 | 0 | 3 |
| FAM189B | TKTL1 | 0.694957 | 4 | 0 | 4 |
| FAM189B | SPC24 | 0.692346 | 5 | 0 | 5 |
| FAM189B | C7orf26 | 0.692051 | 4 | 0 | 3 |
| FAM189B | HSD17B14 | 0.690818 | 4 | 0 | 3 |
| FAM189B | C19orf53 | 0.689602 | 5 | 0 | 5 |
For details and further investigation, click here
