| Full name: exosome component 1 | Alias Symbol: hCsl4p|Csl4p|CSL4|Ski4p|SKI4|CGI-108|p13 | ||
| Type: protein-coding gene | Cytoband: 10q24.1 | ||
| Entrez ID: 51013 | HGNC ID: HGNC:17286 | Ensembl Gene: ENSG00000171311 | OMIM ID: 606493 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EXOSC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOSC1 | 51013 | 222609_s_at | -0.0032 | 0.9955 | |
| GSE20347 | EXOSC1 | 51013 | 218369_s_at | -0.0339 | 0.5326 | |
| GSE23400 | EXOSC1 | 51013 | 218369_s_at | -0.0551 | 0.0013 | |
| GSE26886 | EXOSC1 | 51013 | 222609_s_at | 0.2647 | 0.0909 | |
| GSE29001 | EXOSC1 | 51013 | 218369_s_at | -0.1952 | 0.0559 | |
| GSE38129 | EXOSC1 | 51013 | 218369_s_at | -0.0211 | 0.7041 | |
| GSE45670 | EXOSC1 | 51013 | 222609_s_at | -0.0799 | 0.5614 | |
| GSE53622 | EXOSC1 | 51013 | 62431 | -0.1050 | 0.0322 | |
| GSE53624 | EXOSC1 | 51013 | 62431 | 0.1243 | 0.0041 | |
| GSE63941 | EXOSC1 | 51013 | 222609_s_at | 0.4743 | 0.0868 | |
| GSE77861 | EXOSC1 | 51013 | 222609_s_at | 0.0358 | 0.8649 | |
| GSE97050 | EXOSC1 | 51013 | A_23_P35591 | 0.1287 | 0.5200 | |
| SRP007169 | EXOSC1 | 51013 | RNAseq | -1.0397 | 0.0125 | |
| SRP008496 | EXOSC1 | 51013 | RNAseq | -0.6608 | 0.0235 | |
| SRP064894 | EXOSC1 | 51013 | RNAseq | -0.0126 | 0.9475 | |
| SRP133303 | EXOSC1 | 51013 | RNAseq | -0.0423 | 0.7161 | |
| SRP159526 | EXOSC1 | 51013 | RNAseq | -0.0920 | 0.7023 | |
| SRP193095 | EXOSC1 | 51013 | RNAseq | -0.1384 | 0.2083 | |
| SRP219564 | EXOSC1 | 51013 | RNAseq | -0.0065 | 0.9790 | |
| TCGA | EXOSC1 | 51013 | RNAseq | 0.1131 | 0.0653 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by EXOSC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOSC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOSC1 | 51013 | 0 | 8 | 22 | |
| GSE20123 | EXOSC1 | 51013 | 0 | 7 | 23 | |
| GSE43470 | EXOSC1 | 51013 | 0 | 7 | 36 | |
| GSE46452 | EXOSC1 | 51013 | 0 | 11 | 48 | |
| GSE47630 | EXOSC1 | 51013 | 2 | 14 | 24 | |
| GSE54993 | EXOSC1 | 51013 | 8 | 0 | 62 | |
| GSE54994 | EXOSC1 | 51013 | 2 | 10 | 41 | |
| GSE60625 | EXOSC1 | 51013 | 0 | 0 | 11 | |
| GSE74703 | EXOSC1 | 51013 | 0 | 5 | 31 | |
| GSE74704 | EXOSC1 | 51013 | 0 | 4 | 16 | |
| TCGA | EXOSC1 | 51013 | 5 | 28 | 63 |
Total number of gains: 17; Total number of losses: 94; Total Number of normals: 377.
Somatic mutations of EXOSC1:
Generating mutation plots.
Highly correlated genes for EXOSC1:
Showing top 20/53 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOSC1 | MYBPH | 0.730022 | 3 | 0 | 3 |
| EXOSC1 | MAP3K4 | 0.718633 | 3 | 0 | 3 |
| EXOSC1 | RNF215 | 0.718013 | 3 | 0 | 3 |
| EXOSC1 | APOM | 0.716377 | 3 | 0 | 3 |
| EXOSC1 | TRIM31 | 0.708526 | 3 | 0 | 3 |
| EXOSC1 | MIB2 | 0.686775 | 3 | 0 | 3 |
| EXOSC1 | CLCN1 | 0.680552 | 3 | 0 | 3 |
| EXOSC1 | FBXL15 | 0.659116 | 6 | 0 | 6 |
| EXOSC1 | CDX2 | 0.650658 | 6 | 0 | 4 |
| EXOSC1 | RSPH1 | 0.646626 | 3 | 0 | 3 |
| EXOSC1 | TRIM17 | 0.645811 | 4 | 0 | 3 |
| EXOSC1 | PTCRA | 0.644461 | 5 | 0 | 4 |
| EXOSC1 | OOEP | 0.64381 | 3 | 0 | 3 |
| EXOSC1 | IRF3 | 0.639598 | 3 | 0 | 3 |
| EXOSC1 | KIF17 | 0.632876 | 4 | 0 | 3 |
| EXOSC1 | ZMYND10 | 0.630398 | 4 | 0 | 3 |
| EXOSC1 | TM6SF2 | 0.627007 | 5 | 0 | 4 |
| EXOSC1 | IPO13 | 0.619955 | 5 | 0 | 4 |
| EXOSC1 | ABCC6 | 0.618089 | 5 | 0 | 3 |
| EXOSC1 | SURF2 | 0.617355 | 5 | 0 | 4 |
For details and further investigation, click here
