| Full name: tonsoku like, DNA repair protein | Alias Symbol: IKBR | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 4796 | HGNC ID: HGNC:7801 | Ensembl Gene: ENSG00000160949 | OMIM ID: 604546 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TONSL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TONSL | 4796 | 1558329_at | 0.9932 | 0.0552 | |
| GSE20347 | TONSL | 4796 | 207137_at | -0.0822 | 0.1518 | |
| GSE23400 | TONSL | 4796 | 207137_at | -0.1250 | 0.0001 | |
| GSE26886 | TONSL | 4796 | 1558329_at | 0.3022 | 0.0445 | |
| GSE29001 | TONSL | 4796 | 207137_at | -0.1049 | 0.3704 | |
| GSE38129 | TONSL | 4796 | 207137_at | -0.1190 | 0.0890 | |
| GSE45670 | TONSL | 4796 | 1558330_x_at | 0.6007 | 0.0005 | |
| GSE53622 | TONSL | 4796 | 77348 | 1.6968 | 0.0000 | |
| GSE53624 | TONSL | 4796 | 68680 | 0.1905 | 0.0827 | |
| GSE63941 | TONSL | 4796 | 1558330_x_at | 0.6279 | 0.0508 | |
| GSE77861 | TONSL | 4796 | 1558330_x_at | 0.1594 | 0.4214 | |
| GSE97050 | TONSL | 4796 | A_24_P1054 | 0.4185 | 0.4398 | |
| SRP007169 | TONSL | 4796 | RNAseq | 0.9124 | 0.0624 | |
| SRP008496 | TONSL | 4796 | RNAseq | 0.4706 | 0.1537 | |
| SRP064894 | TONSL | 4796 | RNAseq | 2.0962 | 0.0000 | |
| SRP133303 | TONSL | 4796 | RNAseq | 1.1941 | 0.0001 | |
| SRP159526 | TONSL | 4796 | RNAseq | 1.8324 | 0.0000 | |
| SRP193095 | TONSL | 4796 | RNAseq | 1.2073 | 0.0000 | |
| SRP219564 | TONSL | 4796 | RNAseq | 1.7954 | 0.0019 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by TONSL expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of TONSL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TONSL | 4796 | 17 | 1 | 12 | |
| GSE20123 | TONSL | 4796 | 17 | 1 | 12 | |
| GSE43470 | TONSL | 4796 | 16 | 2 | 25 | |
| GSE46452 | TONSL | 4796 | 28 | 0 | 31 | |
| GSE47630 | TONSL | 4796 | 25 | 1 | 14 | |
| GSE54993 | TONSL | 4796 | 0 | 25 | 45 | |
| GSE54994 | TONSL | 4796 | 39 | 1 | 13 | |
| GSE60625 | TONSL | 4796 | 3 | 4 | 4 | |
| GSE74703 | TONSL | 4796 | 14 | 1 | 21 | |
| GSE74704 | TONSL | 4796 | 10 | 0 | 10 | |
| TCGA | TONSL | 4796 | 63 | 2 | 31 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of TONSL:
Generating mutation plots.
Highly correlated genes for TONSL:
Showing top 20/562 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TONSL | PNPT1 | 0.78664 | 3 | 0 | 3 |
| TONSL | ZGRF1 | 0.750863 | 4 | 0 | 4 |
| TONSL | PTPRCAP | 0.739465 | 3 | 0 | 3 |
| TONSL | DNAJB11 | 0.736885 | 3 | 0 | 3 |
| TONSL | WDR90 | 0.731532 | 3 | 0 | 3 |
| TONSL | GTSE1 | 0.72781 | 4 | 0 | 3 |
| TONSL | FAM91A1 | 0.719993 | 3 | 0 | 3 |
| TONSL | POLE | 0.718544 | 6 | 0 | 5 |
| TONSL | MIB2 | 0.717668 | 3 | 0 | 3 |
| TONSL | CCDC142 | 0.711413 | 3 | 0 | 3 |
| TONSL | BIRC7 | 0.7105 | 3 | 0 | 3 |
| TONSL | IQGAP3 | 0.703384 | 3 | 0 | 3 |
| TONSL | MAMSTR | 0.703187 | 3 | 0 | 3 |
| TONSL | CDX2 | 0.700751 | 3 | 0 | 3 |
| TONSL | ARHGAP22 | 0.699731 | 3 | 0 | 3 |
| TONSL | LCT | 0.698207 | 3 | 0 | 3 |
| TONSL | LRR1 | 0.692897 | 4 | 0 | 4 |
| TONSL | ATP1B3 | 0.692255 | 3 | 0 | 3 |
| TONSL | MFSD10 | 0.690791 | 5 | 0 | 4 |
| TONSL | SLC5A5 | 0.688808 | 4 | 0 | 3 |
For details and further investigation, click here
