| Full name: nth like DNA glycosylase 1 | Alias Symbol: NTH1|OCTS3 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 4913 | HGNC ID: HGNC:8028 | Ensembl Gene: ENSG00000065057 | OMIM ID: 602656 |
| Drug and gene relationship at DGIdb | |||
Expression of NTHL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NTHL1 | 4913 | 209731_at | 0.2863 | 0.4303 | |
| GSE20347 | NTHL1 | 4913 | 209731_at | 0.3950 | 0.0029 | |
| GSE23400 | NTHL1 | 4913 | 209731_at | 0.1385 | 0.0195 | |
| GSE26886 | NTHL1 | 4913 | 209731_at | 0.5976 | 0.0007 | |
| GSE29001 | NTHL1 | 4913 | 209731_at | 0.3018 | 0.3125 | |
| GSE38129 | NTHL1 | 4913 | 209731_at | 0.3439 | 0.0077 | |
| GSE45670 | NTHL1 | 4913 | 209731_at | 0.3229 | 0.0637 | |
| GSE53622 | NTHL1 | 4913 | 152758 | 0.1830 | 0.0432 | |
| GSE53624 | NTHL1 | 4913 | 152758 | 0.3432 | 0.0004 | |
| GSE63941 | NTHL1 | 4913 | 209731_at | 0.8861 | 0.0303 | |
| GSE77861 | NTHL1 | 4913 | 209731_at | 0.2016 | 0.0747 | |
| GSE97050 | NTHL1 | 4913 | A_23_P88904 | 0.3812 | 0.2216 | |
| SRP007169 | NTHL1 | 4913 | RNAseq | -0.4361 | 0.3324 | |
| SRP064894 | NTHL1 | 4913 | RNAseq | 0.5203 | 0.1931 | |
| SRP133303 | NTHL1 | 4913 | RNAseq | 0.2578 | 0.2401 | |
| SRP159526 | NTHL1 | 4913 | RNAseq | 0.6962 | 0.0007 | |
| SRP193095 | NTHL1 | 4913 | RNAseq | 0.1219 | 0.4060 | |
| SRP219564 | NTHL1 | 4913 | RNAseq | 0.4750 | 0.3369 | |
| TCGA | NTHL1 | 4913 | RNAseq | 0.2385 | 0.0031 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NTHL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NTHL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NTHL1 | 4913 | 5 | 5 | 20 | |
| GSE20123 | NTHL1 | 4913 | 5 | 4 | 21 | |
| GSE43470 | NTHL1 | 4913 | 4 | 7 | 32 | |
| GSE46452 | NTHL1 | 4913 | 38 | 1 | 20 | |
| GSE47630 | NTHL1 | 4913 | 13 | 6 | 21 | |
| GSE54993 | NTHL1 | 4913 | 3 | 5 | 62 | |
| GSE54994 | NTHL1 | 4913 | 5 | 9 | 39 | |
| GSE60625 | NTHL1 | 4913 | 4 | 0 | 7 | |
| GSE74703 | NTHL1 | 4913 | 4 | 5 | 27 | |
| GSE74704 | NTHL1 | 4913 | 3 | 2 | 15 | |
| TCGA | NTHL1 | 4913 | 19 | 14 | 63 |
Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.
Somatic mutations of NTHL1:
Generating mutation plots.
Highly correlated genes for NTHL1:
Showing top 20/324 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NTHL1 | MIB2 | 0.799242 | 3 | 0 | 3 |
| NTHL1 | ZNF48 | 0.707976 | 4 | 0 | 4 |
| NTHL1 | CHP2 | 0.707027 | 4 | 0 | 4 |
| NTHL1 | RASGEF1A | 0.698788 | 3 | 0 | 3 |
| NTHL1 | ABTB1 | 0.689052 | 3 | 0 | 3 |
| NTHL1 | THAP3 | 0.670932 | 4 | 0 | 3 |
| NTHL1 | POC1A | 0.670545 | 6 | 0 | 6 |
| NTHL1 | SNRNP25 | 0.669169 | 10 | 0 | 9 |
| NTHL1 | NUBP2 | 0.663442 | 6 | 0 | 4 |
| NTHL1 | TBC1D7 | 0.662836 | 4 | 0 | 3 |
| NTHL1 | UMODL1 | 0.660319 | 3 | 0 | 3 |
| NTHL1 | GALNS | 0.656715 | 5 | 0 | 4 |
| NTHL1 | TMEM216 | 0.652404 | 3 | 0 | 3 |
| NTHL1 | PMEPA1 | 0.652385 | 5 | 0 | 5 |
| NTHL1 | HINFP | 0.647808 | 3 | 0 | 3 |
| NTHL1 | JAKMIP2 | 0.640994 | 3 | 0 | 3 |
| NTHL1 | MSR1 | 0.640327 | 3 | 0 | 3 |
| NTHL1 | TMCO3 | 0.639359 | 4 | 0 | 3 |
| NTHL1 | QPRT | 0.637025 | 4 | 0 | 3 |
| NTHL1 | PRR15 | 0.634007 | 4 | 0 | 3 |
For details and further investigation, click here
