| Full name: matrix metallopeptidase 28 | Alias Symbol: MMP-25|MM28|EPILYSIN|MMP-28 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 79148 | HGNC ID: HGNC:14366 | Ensembl Gene: ENSG00000271447 | OMIM ID: 608417 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP28:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP28 | 79148 | 239272_at | 0.0228 | 0.9891 | |
| GSE20347 | MMP28 | 79148 | 219909_at | -0.6856 | 0.0346 | |
| GSE23400 | MMP28 | 79148 | 219909_at | -0.1291 | 0.2070 | |
| GSE26886 | MMP28 | 79148 | 224207_x_at | -0.1187 | 0.4271 | |
| GSE29001 | MMP28 | 79148 | 219909_at | -0.2761 | 0.7062 | |
| GSE38129 | MMP28 | 79148 | 219909_at | -0.8773 | 0.0030 | |
| GSE45670 | MMP28 | 79148 | 239272_at | -0.2912 | 0.5622 | |
| GSE53622 | MMP28 | 79148 | 10066 | -0.2929 | 0.0733 | |
| GSE53624 | MMP28 | 79148 | 10066 | -0.4762 | 0.0000 | |
| GSE63941 | MMP28 | 79148 | 224207_x_at | 0.5489 | 0.0021 | |
| GSE77861 | MMP28 | 79148 | 224207_x_at | -0.0993 | 0.5938 | |
| GSE97050 | MMP28 | 79148 | A_24_P196592 | 0.1739 | 0.6907 | |
| SRP007169 | MMP28 | 79148 | RNAseq | -2.1369 | 0.0088 | |
| SRP064894 | MMP28 | 79148 | RNAseq | -0.1995 | 0.5689 | |
| SRP133303 | MMP28 | 79148 | RNAseq | 0.7584 | 0.2352 | |
| SRP159526 | MMP28 | 79148 | RNAseq | -2.4875 | 0.0000 | |
| SRP193095 | MMP28 | 79148 | RNAseq | -0.7133 | 0.0131 | |
| SRP219564 | MMP28 | 79148 | RNAseq | 0.2992 | 0.6753 | |
| TCGA | MMP28 | 79148 | RNAseq | -0.0600 | 0.7951 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MMP28 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP28:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP28 | 79148 | 5 | 1 | 24 | |
| GSE20123 | MMP28 | 79148 | 5 | 1 | 24 | |
| GSE43470 | MMP28 | 79148 | 1 | 2 | 40 | |
| GSE46452 | MMP28 | 79148 | 34 | 0 | 25 | |
| GSE47630 | MMP28 | 79148 | 7 | 1 | 32 | |
| GSE54993 | MMP28 | 79148 | 3 | 3 | 64 | |
| GSE54994 | MMP28 | 79148 | 8 | 6 | 39 | |
| GSE60625 | MMP28 | 79148 | 4 | 0 | 7 | |
| GSE74703 | MMP28 | 79148 | 1 | 1 | 34 | |
| GSE74704 | MMP28 | 79148 | 3 | 1 | 16 | |
| TCGA | MMP28 | 79148 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of MMP28:
Generating mutation plots.
Highly correlated genes for MMP28:
Showing all 12 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP28 | MPV17L | 0.626536 | 3 | 0 | 3 |
| MMP28 | CD33 | 0.62571 | 3 | 0 | 3 |
| MMP28 | GNAO1 | 0.615503 | 3 | 0 | 3 |
| MMP28 | DLX1 | 0.599641 | 3 | 0 | 3 |
| MMP28 | DENND6A | 0.571097 | 3 | 0 | 3 |
| MMP28 | MAPT-AS1 | 0.551953 | 3 | 0 | 3 |
| MMP28 | KCNJ15 | 0.539237 | 4 | 0 | 3 |
| MMP28 | KIR2DL2 | 0.535642 | 5 | 0 | 4 |
| MMP28 | CXADR | 0.527711 | 4 | 0 | 3 |
| MMP28 | YBX2 | 0.516753 | 4 | 0 | 3 |
| MMP28 | DPYD | 0.501473 | 8 | 0 | 3 |
| MMP28 | HOOK1 | 0.500252 | 5 | 0 | 3 |
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