| Full name: dihydropyrimidine dehydrogenase | Alias Symbol: DPD | ||
| Type: protein-coding gene | Cytoband: 1p21.3 | ||
| Entrez ID: 1806 | HGNC ID: HGNC:3012 | Ensembl Gene: ENSG00000188641 | OMIM ID: 612779 |
| Drug and gene relationship at DGIdb | |||
Expression of DPYD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DPYD | 1806 | 204646_at | -0.8472 | 0.2278 | |
| GSE20347 | DPYD | 1806 | 204646_at | -2.1763 | 0.0000 | |
| GSE23400 | DPYD | 1806 | 204646_at | -0.5950 | 0.0004 | |
| GSE26886 | DPYD | 1806 | 204646_at | -1.7866 | 0.0039 | |
| GSE29001 | DPYD | 1806 | 204646_at | -1.0725 | 0.1271 | |
| GSE38129 | DPYD | 1806 | 204646_at | -1.7542 | 0.0000 | |
| GSE45670 | DPYD | 1806 | 204646_at | -0.3045 | 0.4768 | |
| GSE53622 | DPYD | 1806 | 18336 | -0.7516 | 0.0000 | |
| GSE53624 | DPYD | 1806 | 18336 | -1.0082 | 0.0000 | |
| GSE63941 | DPYD | 1806 | 204646_at | -2.2568 | 0.2583 | |
| GSE77861 | DPYD | 1806 | 204646_at | -2.4141 | 0.0009 | |
| GSE97050 | DPYD | 1806 | A_23_P135548 | 0.1837 | 0.3720 | |
| SRP007169 | DPYD | 1806 | RNAseq | -1.0576 | 0.0202 | |
| SRP008496 | DPYD | 1806 | RNAseq | -1.1657 | 0.0007 | |
| SRP064894 | DPYD | 1806 | RNAseq | -0.1424 | 0.6806 | |
| SRP133303 | DPYD | 1806 | RNAseq | -0.3113 | 0.1828 | |
| SRP159526 | DPYD | 1806 | RNAseq | -1.4135 | 0.0004 | |
| SRP193095 | DPYD | 1806 | RNAseq | -0.5813 | 0.0015 | |
| SRP219564 | DPYD | 1806 | RNAseq | 0.0846 | 0.9088 | |
| TCGA | DPYD | 1806 | RNAseq | -0.0553 | 0.7092 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by DPYD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DPYD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DPYD | 1806 | 0 | 9 | 21 | |
| GSE20123 | DPYD | 1806 | 0 | 9 | 21 | |
| GSE43470 | DPYD | 1806 | 2 | 6 | 35 | |
| GSE46452 | DPYD | 1806 | 1 | 1 | 57 | |
| GSE47630 | DPYD | 1806 | 8 | 6 | 26 | |
| GSE54993 | DPYD | 1806 | 0 | 1 | 69 | |
| GSE54994 | DPYD | 1806 | 6 | 3 | 44 | |
| GSE60625 | DPYD | 1806 | 0 | 0 | 11 | |
| GSE74703 | DPYD | 1806 | 1 | 5 | 30 | |
| GSE74704 | DPYD | 1806 | 0 | 5 | 15 | |
| TCGA | DPYD | 1806 | 9 | 26 | 61 |
Total number of gains: 27; Total number of losses: 71; Total Number of normals: 390.
Somatic mutations of DPYD:
Generating mutation plots.
Highly correlated genes for DPYD:
Showing top 20/895 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DPYD | SREK1 | 0.719143 | 3 | 0 | 3 |
| DPYD | ZNF436 | 0.699242 | 4 | 0 | 3 |
| DPYD | PLXNB2 | 0.694502 | 3 | 0 | 3 |
| DPYD | ACTR3C | 0.692161 | 4 | 0 | 4 |
| DPYD | SMDT1 | 0.672759 | 3 | 0 | 3 |
| DPYD | CMPK1 | 0.66589 | 11 | 0 | 9 |
| DPYD | SCLT1 | 0.660098 | 3 | 0 | 3 |
| DPYD | LRG1 | 0.65773 | 4 | 0 | 3 |
| DPYD | FAM114A2 | 0.657328 | 11 | 0 | 10 |
| DPYD | STX12 | 0.656822 | 11 | 0 | 10 |
| DPYD | TRIM6 | 0.656639 | 8 | 0 | 7 |
| DPYD | ELP6 | 0.65373 | 3 | 0 | 3 |
| DPYD | ELMOD2 | 0.652049 | 4 | 0 | 4 |
| DPYD | GOLGA4 | 0.651037 | 8 | 0 | 6 |
| DPYD | SPINT1 | 0.646058 | 4 | 0 | 3 |
| DPYD | STAMBP | 0.641053 | 3 | 0 | 3 |
| DPYD | TMEM33 | 0.638232 | 5 | 0 | 4 |
| DPYD | ARL6IP5 | 0.637838 | 13 | 0 | 10 |
| DPYD | TLR3 | 0.636502 | 11 | 0 | 11 |
| DPYD | FCHO2 | 0.636324 | 6 | 0 | 6 |
For details and further investigation, click here
