| Full name: hook microtubule tethering protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p32.1 | ||
| Entrez ID: 51361 | HGNC ID: HGNC:19884 | Ensembl Gene: ENSG00000134709 | OMIM ID: 607820 |
| Drug and gene relationship at DGIdb | |||
Expression of HOOK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HOOK1 | 51361 | 225792_at | 0.2892 | 0.8216 | |
| GSE20347 | HOOK1 | 51361 | 219976_at | -0.7742 | 0.0005 | |
| GSE23400 | HOOK1 | 51361 | 219976_at | -0.3046 | 0.0021 | |
| GSE26886 | HOOK1 | 51361 | 225792_at | -1.9186 | 0.0000 | |
| GSE29001 | HOOK1 | 51361 | 219976_at | -0.7618 | 0.0908 | |
| GSE38129 | HOOK1 | 51361 | 219976_at | -0.2860 | 0.3826 | |
| GSE45670 | HOOK1 | 51361 | 225792_at | -0.2830 | 0.2587 | |
| GSE53622 | HOOK1 | 51361 | 8899 | -0.5940 | 0.0085 | |
| GSE53624 | HOOK1 | 51361 | 3084 | -1.2457 | 0.0000 | |
| GSE63941 | HOOK1 | 51361 | 225792_at | 4.6970 | 0.0001 | |
| GSE77861 | HOOK1 | 51361 | 225792_at | -0.9224 | 0.0439 | |
| GSE97050 | HOOK1 | 51361 | A_24_P921897 | 0.5493 | 0.3564 | |
| SRP007169 | HOOK1 | 51361 | RNAseq | -1.4270 | 0.0000 | |
| SRP008496 | HOOK1 | 51361 | RNAseq | -1.5994 | 0.0000 | |
| SRP064894 | HOOK1 | 51361 | RNAseq | -1.5255 | 0.0002 | |
| SRP133303 | HOOK1 | 51361 | RNAseq | -0.9105 | 0.0047 | |
| SRP159526 | HOOK1 | 51361 | RNAseq | -1.1723 | 0.0003 | |
| SRP193095 | HOOK1 | 51361 | RNAseq | -1.5008 | 0.0000 | |
| SRP219564 | HOOK1 | 51361 | RNAseq | -0.8096 | 0.4739 | |
| TCGA | HOOK1 | 51361 | RNAseq | -0.1218 | 0.4350 |
Upregulated datasets: 1; Downregulated datasets: 7.
Survival by HOOK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HOOK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HOOK1 | 51361 | 3 | 5 | 22 | |
| GSE20123 | HOOK1 | 51361 | 3 | 4 | 23 | |
| GSE43470 | HOOK1 | 51361 | 6 | 2 | 35 | |
| GSE46452 | HOOK1 | 51361 | 2 | 1 | 56 | |
| GSE47630 | HOOK1 | 51361 | 8 | 5 | 27 | |
| GSE54993 | HOOK1 | 51361 | 0 | 0 | 70 | |
| GSE54994 | HOOK1 | 51361 | 7 | 4 | 42 | |
| GSE60625 | HOOK1 | 51361 | 0 | 0 | 11 | |
| GSE74703 | HOOK1 | 51361 | 5 | 2 | 29 | |
| GSE74704 | HOOK1 | 51361 | 2 | 0 | 18 | |
| TCGA | HOOK1 | 51361 | 10 | 20 | 66 |
Total number of gains: 46; Total number of losses: 43; Total Number of normals: 399.
Somatic mutations of HOOK1:
Generating mutation plots.
Highly correlated genes for HOOK1:
Showing top 20/655 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HOOK1 | MAL2 | 0.754155 | 8 | 0 | 7 |
| HOOK1 | FAM160A1 | 0.74769 | 5 | 0 | 5 |
| HOOK1 | KDF1 | 0.740752 | 4 | 0 | 4 |
| HOOK1 | ARAP2 | 0.735977 | 3 | 0 | 3 |
| HOOK1 | SYTL1 | 0.734649 | 6 | 0 | 6 |
| HOOK1 | MIR205HG | 0.72304 | 3 | 0 | 3 |
| HOOK1 | DMKN | 0.716698 | 5 | 0 | 4 |
| HOOK1 | MARVELD2 | 0.701991 | 5 | 0 | 4 |
| HOOK1 | NIPAL1 | 0.701983 | 3 | 0 | 3 |
| HOOK1 | AASDH | 0.701061 | 3 | 0 | 3 |
| HOOK1 | ZNF165 | 0.695666 | 4 | 0 | 3 |
| HOOK1 | CRB3 | 0.695328 | 5 | 0 | 4 |
| HOOK1 | MAP4K5 | 0.694982 | 4 | 0 | 3 |
| HOOK1 | COX15 | 0.692728 | 3 | 0 | 3 |
| HOOK1 | RNF149 | 0.685102 | 4 | 0 | 4 |
| HOOK1 | KIAA1522 | 0.68483 | 4 | 0 | 3 |
| HOOK1 | COG3 | 0.678562 | 3 | 0 | 3 |
| HOOK1 | MPZL3 | 0.678447 | 6 | 0 | 6 |
| HOOK1 | MAB21L3 | 0.677266 | 4 | 0 | 4 |
| HOOK1 | YTHDF2 | 0.675061 | 4 | 0 | 3 |
For details and further investigation, click here
