| Full name: CD33 molecule | Alias Symbol: SIGLEC3|SIGLEC-3|p67|FLJ00391 | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 945 | HGNC ID: HGNC:1659 | Ensembl Gene: ENSG00000105383 | OMIM ID: 159590 |
| Drug and gene relationship at DGIdb | |||
Expression of CD33:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD33 | 945 | 206120_at | 0.0114 | 0.9840 | |
| GSE20347 | CD33 | 945 | 206120_at | -0.0230 | 0.8112 | |
| GSE23400 | CD33 | 945 | 206120_at | -0.1956 | 0.0000 | |
| GSE26886 | CD33 | 945 | 206120_at | -0.0986 | 0.4769 | |
| GSE29001 | CD33 | 945 | 206120_at | -0.2048 | 0.2636 | |
| GSE38129 | CD33 | 945 | 206120_at | -0.1565 | 0.1101 | |
| GSE45670 | CD33 | 945 | 206120_at | -0.2929 | 0.0798 | |
| GSE63941 | CD33 | 945 | 206120_at | 0.4464 | 0.0047 | |
| GSE77861 | CD33 | 945 | 206120_at | -0.1387 | 0.4057 | |
| GSE97050 | CD33 | A_21_P0000094 | 0.4122 | 0.2966 | ||
| SRP064894 | CD33 | 945 | RNAseq | 0.6219 | 0.1081 | |
| SRP133303 | CD33 | 945 | RNAseq | -0.3007 | 0.3170 | |
| SRP159526 | CD33 | 945 | RNAseq | -0.7250 | 0.2980 | |
| SRP219564 | CD33 | 945 | RNAseq | 0.8235 | 0.3144 | |
| TCGA | CD33 | 945 | RNAseq | -0.1434 | 0.5435 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CD33 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CD33:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD33 | 945 | 3 | 4 | 23 | |
| GSE20123 | CD33 | 945 | 3 | 3 | 24 | |
| GSE43470 | CD33 | 945 | 3 | 12 | 28 | |
| GSE46452 | CD33 | 945 | 45 | 1 | 13 | |
| GSE47630 | CD33 | 945 | 9 | 6 | 25 | |
| GSE54993 | CD33 | 945 | 17 | 4 | 49 | |
| GSE54994 | CD33 | 945 | 4 | 14 | 35 | |
| GSE60625 | CD33 | 945 | 9 | 0 | 2 | |
| GSE74703 | CD33 | 945 | 3 | 8 | 25 | |
| GSE74704 | CD33 | 945 | 3 | 1 | 16 | |
| TCGA | CD33 | 945 | 14 | 19 | 63 |
Total number of gains: 113; Total number of losses: 72; Total Number of normals: 303.
Somatic mutations of CD33:
Generating mutation plots.
Highly correlated genes for CD33:
Showing top 20/756 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD33 | CD37 | 0.757922 | 3 | 0 | 3 |
| CD33 | ITK | 0.755319 | 3 | 0 | 3 |
| CD33 | HHLA1 | 0.747563 | 5 | 0 | 5 |
| CD33 | SETD5 | 0.726627 | 3 | 0 | 3 |
| CD33 | GIMAP7 | 0.724291 | 3 | 0 | 3 |
| CD33 | EXOC3L2 | 0.718552 | 3 | 0 | 3 |
| CD33 | PARVG | 0.698445 | 3 | 0 | 3 |
| CD33 | FLI1 | 0.697891 | 6 | 0 | 6 |
| CD33 | IL2RG | 0.694697 | 5 | 0 | 4 |
| CD33 | CER1 | 0.688694 | 6 | 0 | 6 |
| CD33 | USP5 | 0.687661 | 3 | 0 | 3 |
| CD33 | TRAF1 | 0.6855 | 4 | 0 | 3 |
| CD33 | HAND1 | 0.68376 | 6 | 0 | 6 |
| CD33 | IKZF3 | 0.680971 | 4 | 0 | 4 |
| CD33 | GIMAP8 | 0.680819 | 3 | 0 | 3 |
| CD33 | IFNA5 | 0.679584 | 3 | 0 | 3 |
| CD33 | CEP85 | 0.676715 | 3 | 0 | 3 |
| CD33 | CPVL | 0.676496 | 3 | 0 | 3 |
| CD33 | CLEC14A | 0.675823 | 4 | 0 | 4 |
| CD33 | GIMAP6 | 0.674473 | 4 | 0 | 3 |
For details and further investigation, click here
