| Full name: metaxin 1 | Alias Symbol: MTXN | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 4580 | HGNC ID: HGNC:7504 | Ensembl Gene: ENSG00000173171 | OMIM ID: 600605 |
| Drug and gene relationship at DGIdb | |||
Expression of MTX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTX1 | 4580 | 210386_s_at | 0.6061 | 0.0571 | |
| GSE20347 | MTX1 | 4580 | 210386_s_at | 0.2453 | 0.0187 | |
| GSE23400 | MTX1 | 4580 | 210386_s_at | 0.4664 | 0.0000 | |
| GSE26886 | MTX1 | 4580 | 210386_s_at | 1.2555 | 0.0000 | |
| GSE29001 | MTX1 | 4580 | 210386_s_at | 0.2411 | 0.2456 | |
| GSE38129 | MTX1 | 4580 | 210386_s_at | 0.4232 | 0.0000 | |
| GSE45670 | MTX1 | 4580 | 210386_s_at | 0.2968 | 0.0034 | |
| GSE53622 | MTX1 | 4580 | 29701 | 0.3776 | 0.0009 | |
| GSE53624 | MTX1 | 4580 | 29701 | 0.4652 | 0.0000 | |
| GSE63941 | MTX1 | 4580 | 210386_s_at | 0.8269 | 0.0166 | |
| GSE77861 | MTX1 | 4580 | 210386_s_at | 0.3395 | 0.0901 | |
| GSE97050 | MTX1 | 4580 | A_23_P137865 | 0.4173 | 0.1454 | |
| SRP007169 | MTX1 | 4580 | RNAseq | -0.3660 | 0.3197 | |
| SRP008496 | MTX1 | 4580 | RNAseq | -0.2126 | 0.3297 | |
| SRP064894 | MTX1 | 4580 | RNAseq | 0.5512 | 0.0332 | |
| SRP133303 | MTX1 | 4580 | RNAseq | 0.3507 | 0.0524 | |
| SRP159526 | MTX1 | 4580 | RNAseq | 0.6195 | 0.0047 | |
| SRP193095 | MTX1 | 4580 | RNAseq | 0.2706 | 0.0184 | |
| SRP219564 | MTX1 | 4580 | RNAseq | 0.7485 | 0.0430 | |
| TCGA | MTX1 | 4580 | RNAseq | 0.1899 | 0.0379 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MTX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTX1 | 4580 | 14 | 0 | 16 | |
| GSE20123 | MTX1 | 4580 | 13 | 0 | 17 | |
| GSE43470 | MTX1 | 4580 | 7 | 2 | 34 | |
| GSE46452 | MTX1 | 4580 | 2 | 1 | 56 | |
| GSE47630 | MTX1 | 4580 | 14 | 0 | 26 | |
| GSE54993 | MTX1 | 4580 | 0 | 4 | 66 | |
| GSE54994 | MTX1 | 4580 | 16 | 0 | 37 | |
| GSE60625 | MTX1 | 4580 | 0 | 0 | 11 | |
| GSE74703 | MTX1 | 4580 | 7 | 1 | 28 | |
| GSE74704 | MTX1 | 4580 | 6 | 0 | 14 | |
| TCGA | MTX1 | 4580 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 10; Total Number of normals: 361.
Somatic mutations of MTX1:
Generating mutation plots.
Highly correlated genes for MTX1:
Showing top 20/1626 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTX1 | TRADD | 0.784262 | 3 | 0 | 3 |
| MTX1 | GAS2L1 | 0.771365 | 4 | 0 | 4 |
| MTX1 | DHX37 | 0.746879 | 5 | 0 | 4 |
| MTX1 | SPATA5 | 0.746414 | 3 | 0 | 3 |
| MTX1 | ARL2 | 0.739805 | 4 | 0 | 4 |
| MTX1 | RILPL1 | 0.7377 | 3 | 0 | 3 |
| MTX1 | ZCCHC3 | 0.737482 | 3 | 0 | 3 |
| MTX1 | ZNF703 | 0.726633 | 3 | 0 | 3 |
| MTX1 | UBTD2 | 0.721528 | 4 | 0 | 3 |
| MTX1 | RILPL2 | 0.721457 | 3 | 0 | 3 |
| MTX1 | RAVER1 | 0.71859 | 4 | 0 | 4 |
| MTX1 | ZCCHC17 | 0.718182 | 3 | 0 | 3 |
| MTX1 | NOL10 | 0.717289 | 7 | 0 | 7 |
| MTX1 | PIK3R3 | 0.716686 | 3 | 0 | 3 |
| MTX1 | NACC1 | 0.713331 | 5 | 0 | 5 |
| MTX1 | UHRF1BP1 | 0.712104 | 5 | 0 | 5 |
| MTX1 | PMPCB | 0.708401 | 3 | 0 | 3 |
| MTX1 | MCMBP | 0.706922 | 4 | 0 | 3 |
| MTX1 | PET117 | 0.706664 | 4 | 0 | 4 |
| MTX1 | ZNF628 | 0.704706 | 4 | 0 | 3 |
For details and further investigation, click here
