| Full name: nucleus accumbens associated 1 | Alias Symbol: NAC1|NAC-1|BEND8|BTBD30 | ||
| Type: protein-coding gene | Cytoband: 19p13.13 | ||
| Entrez ID: 112939 | HGNC ID: HGNC:20967 | Ensembl Gene: ENSG00000160877 | OMIM ID: 610672 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NACC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NACC1 | 112939 | 227651_at | 0.8686 | 0.1858 | |
| GSE26886 | NACC1 | 112939 | 227651_at | 0.7515 | 0.0001 | |
| GSE45670 | NACC1 | 112939 | 227651_at | 0.3089 | 0.0066 | |
| GSE63941 | NACC1 | 112939 | 227651_at | 0.3062 | 0.3488 | |
| GSE77861 | NACC1 | 112939 | 227651_at | 0.3123 | 0.0287 | |
| GSE97050 | NACC1 | 112939 | A_24_P915007 | 0.2163 | 0.4049 | |
| SRP007169 | NACC1 | 112939 | RNAseq | -0.3541 | 0.2744 | |
| SRP008496 | NACC1 | 112939 | RNAseq | -0.2488 | 0.1125 | |
| SRP064894 | NACC1 | 112939 | RNAseq | 0.7439 | 0.0008 | |
| SRP133303 | NACC1 | 112939 | RNAseq | 0.7459 | 0.0000 | |
| SRP159526 | NACC1 | 112939 | RNAseq | 0.6303 | 0.0252 | |
| SRP193095 | NACC1 | 112939 | RNAseq | 0.6223 | 0.0000 | |
| SRP219564 | NACC1 | 112939 | RNAseq | 0.5610 | 0.0745 | |
| TCGA | NACC1 | 112939 | RNAseq | 0.1465 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NACC1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NACC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NACC1 | 112939 | 4 | 2 | 24 | |
| GSE20123 | NACC1 | 112939 | 3 | 1 | 26 | |
| GSE43470 | NACC1 | 112939 | 2 | 6 | 35 | |
| GSE46452 | NACC1 | 112939 | 47 | 1 | 11 | |
| GSE47630 | NACC1 | 112939 | 4 | 7 | 29 | |
| GSE54993 | NACC1 | 112939 | 16 | 3 | 51 | |
| GSE54994 | NACC1 | 112939 | 6 | 13 | 34 | |
| GSE60625 | NACC1 | 112939 | 9 | 0 | 2 | |
| GSE74703 | NACC1 | 112939 | 2 | 4 | 30 | |
| GSE74704 | NACC1 | 112939 | 0 | 1 | 19 | |
| TCGA | NACC1 | 112939 | 18 | 13 | 65 |
Total number of gains: 111; Total number of losses: 51; Total Number of normals: 326.
Somatic mutations of NACC1:
Generating mutation plots.
Highly correlated genes for NACC1:
Showing top 20/1218 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NACC1 | NAA60 | 0.843103 | 3 | 0 | 3 |
| NACC1 | SNTA1 | 0.833806 | 3 | 0 | 3 |
| NACC1 | ZNF628 | 0.82423 | 3 | 0 | 3 |
| NACC1 | ZBTB2 | 0.817097 | 3 | 0 | 3 |
| NACC1 | EP300 | 0.816021 | 3 | 0 | 3 |
| NACC1 | ELOF1 | 0.809132 | 5 | 0 | 5 |
| NACC1 | ALG3 | 0.80909 | 3 | 0 | 3 |
| NACC1 | PEX10 | 0.805014 | 3 | 0 | 3 |
| NACC1 | GORAB | 0.797158 | 3 | 0 | 3 |
| NACC1 | NOTCH3 | 0.790225 | 3 | 0 | 3 |
| NACC1 | TRIM28 | 0.788724 | 4 | 0 | 3 |
| NACC1 | CDK18 | 0.787679 | 3 | 0 | 3 |
| NACC1 | KHSRP | 0.786228 | 6 | 0 | 6 |
| NACC1 | POLR1C | 0.785601 | 3 | 0 | 3 |
| NACC1 | PRCC | 0.783483 | 4 | 0 | 4 |
| NACC1 | DNAJC9 | 0.782933 | 3 | 0 | 3 |
| NACC1 | MYO5A | 0.781864 | 3 | 0 | 3 |
| NACC1 | C1orf216 | 0.778939 | 3 | 0 | 3 |
| NACC1 | UBTD1 | 0.775191 | 3 | 0 | 3 |
| NACC1 | LTBR | 0.774603 | 4 | 0 | 4 |
For details and further investigation, click here
