| Full name: peptidase, mitochondrial processing beta subunit | Alias Symbol: MPPB|MPPP52 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 9512 | HGNC ID: HGNC:9119 | Ensembl Gene: ENSG00000105819 | OMIM ID: 603131 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PMPCB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PMPCB | 9512 | 201682_at | 0.1275 | 0.6753 | |
| GSE20347 | PMPCB | 9512 | 201682_at | 0.3670 | 0.0056 | |
| GSE23400 | PMPCB | 9512 | 201682_at | 0.2190 | 0.0000 | |
| GSE26886 | PMPCB | 9512 | 201682_at | 1.1029 | 0.0000 | |
| GSE29001 | PMPCB | 9512 | 201682_at | 0.2002 | 0.5068 | |
| GSE38129 | PMPCB | 9512 | 201682_at | 0.3233 | 0.0008 | |
| GSE45670 | PMPCB | 9512 | 201682_at | 0.0239 | 0.8872 | |
| GSE63941 | PMPCB | 9512 | 201682_at | 0.3982 | 0.3408 | |
| GSE77861 | PMPCB | 9512 | 201682_at | 0.2243 | 0.2638 | |
| GSE97050 | PMPCB | 9512 | A_33_P3294162 | -0.3024 | 0.3343 | |
| SRP007169 | PMPCB | 9512 | RNAseq | 0.5931 | 0.1206 | |
| SRP008496 | PMPCB | 9512 | RNAseq | 0.7736 | 0.0023 | |
| SRP064894 | PMPCB | 9512 | RNAseq | -0.0511 | 0.6933 | |
| SRP133303 | PMPCB | 9512 | RNAseq | -0.0453 | 0.7179 | |
| SRP159526 | PMPCB | 9512 | RNAseq | -0.1450 | 0.5670 | |
| SRP193095 | PMPCB | 9512 | RNAseq | -0.0436 | 0.7114 | |
| SRP219564 | PMPCB | 9512 | RNAseq | -0.0337 | 0.9264 | |
| TCGA | PMPCB | 9512 | RNAseq | -0.0349 | 0.4525 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PMPCB expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PMPCB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PMPCB | 9512 | 13 | 0 | 17 | |
| GSE20123 | PMPCB | 9512 | 13 | 0 | 17 | |
| GSE43470 | PMPCB | 9512 | 6 | 1 | 36 | |
| GSE46452 | PMPCB | 9512 | 10 | 1 | 48 | |
| GSE47630 | PMPCB | 9512 | 7 | 3 | 30 | |
| GSE54993 | PMPCB | 9512 | 1 | 10 | 59 | |
| GSE54994 | PMPCB | 9512 | 15 | 3 | 35 | |
| GSE60625 | PMPCB | 9512 | 0 | 0 | 11 | |
| GSE74703 | PMPCB | 9512 | 6 | 1 | 29 | |
| GSE74704 | PMPCB | 9512 | 9 | 0 | 11 | |
| TCGA | PMPCB | 9512 | 54 | 6 | 36 |
Total number of gains: 134; Total number of losses: 25; Total Number of normals: 329.
Somatic mutations of PMPCB:
Generating mutation plots.
Highly correlated genes for PMPCB:
Showing top 20/945 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PMPCB | MCPH1 | 0.817565 | 3 | 0 | 3 |
| PMPCB | RILPL2 | 0.811554 | 3 | 0 | 3 |
| PMPCB | ATP11C | 0.806383 | 3 | 0 | 3 |
| PMPCB | STXBP4 | 0.803502 | 3 | 0 | 3 |
| PMPCB | PARP8 | 0.790685 | 3 | 0 | 3 |
| PMPCB | RBM22 | 0.789663 | 3 | 0 | 3 |
| PMPCB | LSM10 | 0.789598 | 3 | 0 | 3 |
| PMPCB | DOCK7 | 0.788665 | 4 | 0 | 4 |
| PMPCB | EIF3L | 0.788331 | 3 | 0 | 3 |
| PMPCB | TMED8 | 0.786917 | 3 | 0 | 3 |
| PMPCB | NEK7 | 0.786655 | 3 | 0 | 3 |
| PMPCB | CYB5D1 | 0.78283 | 3 | 0 | 3 |
| PMPCB | ZBTB26 | 0.772429 | 3 | 0 | 3 |
| PMPCB | ZXDB | 0.768928 | 3 | 0 | 3 |
| PMPCB | TCTN3 | 0.762477 | 3 | 0 | 3 |
| PMPCB | RICTOR | 0.76116 | 3 | 0 | 3 |
| PMPCB | TIAM2 | 0.759313 | 3 | 0 | 3 |
| PMPCB | NOL9 | 0.759022 | 4 | 0 | 3 |
| PMPCB | CDC42SE2 | 0.758531 | 3 | 0 | 3 |
| PMPCB | ZNF691 | 0.755462 | 3 | 0 | 3 |
For details and further investigation, click here
