RAVER1

 

Full name: ribonucleoprotein, PTB binding 1 Alias Symbol: KIAA1978
Type: protein-coding gene Cytoband: 19p13.2
Entrez ID: 125950 HGNC ID: HGNC:30296 Ensembl Gene: ENSG00000161847 OMIM ID: 609950
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RAVER1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RAVER1 125950 223425_at 0.7162 0.1596
GSE26886 RAVER1 125950 223425_at 0.6251 0.0001
GSE45670 RAVER1 125950 223425_at 0.1576 0.0835
GSE53622 RAVER1 125950 92256 0.3217 0.0000
GSE53624 RAVER1 125950 92256 0.1826 0.0216
GSE63941 RAVER1 125950 223425_at 1.0477 0.0066
GSE77861 RAVER1 125950 223425_at 0.3394 0.0202
GSE97050 RAVER1 125950 A_24_P126557 0.7542 0.1175
SRP007169 RAVER1 125950 RNAseq 1.0066 0.1179
SRP008496 RAVER1 125950 RNAseq 0.8187 0.0218
SRP064894 RAVER1 125950 RNAseq 0.9960 0.0000
SRP133303 RAVER1 125950 RNAseq 0.6271 0.0002
SRP159526 RAVER1 125950 RNAseq 0.7045 0.0273
SRP193095 RAVER1 125950 RNAseq 0.6177 0.0001
SRP219564 RAVER1 125950 RNAseq 1.1242 0.0032
TCGA RAVER1 125950 RNAseq 0.1799 0.0001

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by RAVER1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RAVER1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RAVER1 125950 4 3 23
GSE20123 RAVER1 125950 3 1 26
GSE43470 RAVER1 125950 3 6 34
GSE46452 RAVER1 125950 47 1 11
GSE47630 RAVER1 125950 4 7 29
GSE54993 RAVER1 125950 16 3 51
GSE54994 RAVER1 125950 7 13 33
GSE60625 RAVER1 125950 9 0 2
GSE74703 RAVER1 125950 3 4 29
GSE74704 RAVER1 125950 0 1 19
TCGA RAVER1 125950 13 15 68

Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.  

 

Somatic mutations of RAVER1:

 

Generating mutation plots.

 

Highly correlated genes for RAVER1:

 

Showing top 20/1251 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RAVER1ANAPC50.840305303
RAVER1AP2B10.830471404
RAVER1TAS2R430.816162303
RAVER1LSM20.804361303
RAVER1PRR30.802387303
RAVER1ZNF5580.790797303
RAVER1SF10.789792303
RAVER1NOM10.788291303
RAVER1PRKCSH0.783502706
RAVER1ZNF2020.7834303
RAVER1TUBA1B0.782177403
RAVER1ESCO10.780871303
RAVER1CPT1A0.777392303
RAVER1ELF40.774768404
RAVER1RAD23A0.774372707
RAVER1GLG10.774146303
RAVER1PACS10.77344404
RAVER1PARK70.770583303
RAVER1SRSF60.768455303
RAVER1INTS10.764541303

For details and further investigation, click here