ARL2

 

Full name: ADP ribosylation factor like GTPase 2 Alias Symbol: ARFL2
Type: protein-coding gene Cytoband: 11q13.1
Entrez ID: 402 HGNC ID: HGNC:693 Ensembl Gene: ENSG00000213465 OMIM ID: 601175
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ARL2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ARL2 402 202564_x_at -0.1739 0.7625
GSE20347 ARL2 402 202564_x_at 0.1208 0.4747
GSE23400 ARL2 402 202564_x_at 0.1703 0.0166
GSE26886 ARL2 402 202564_x_at 0.9357 0.0001
GSE29001 ARL2 402 202564_x_at 0.0997 0.6165
GSE38129 ARL2 402 202564_x_at 0.0033 0.9864
GSE45670 ARL2 402 202564_x_at -0.0242 0.9092
GSE53622 ARL2 402 117857 0.2276 0.0019
GSE53624 ARL2 402 117857 0.4078 0.0000
GSE63941 ARL2 402 202564_x_at 0.9060 0.0628
GSE77861 ARL2 402 202564_x_at 0.2604 0.1343
GSE97050 ARL2 402 A_23_P98252 -0.0215 0.9322
SRP007169 ARL2 402 RNAseq -0.0151 0.9704
SRP008496 ARL2 402 RNAseq 0.0002 0.9994
SRP064894 ARL2 402 RNAseq 0.0106 0.9720
SRP133303 ARL2 402 RNAseq 0.2030 0.3971
SRP159526 ARL2 402 RNAseq 0.2238 0.2512
SRP193095 ARL2 402 RNAseq 0.4600 0.0016
SRP219564 ARL2 402 RNAseq 0.0978 0.8474
TCGA ARL2 402 RNAseq 0.1444 0.0158

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ARL2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ARL2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ARL2 402 7 6 17
GSE20123 ARL2 402 7 6 17
GSE43470 ARL2 402 2 3 38
GSE46452 ARL2 402 10 4 45
GSE47630 ARL2 402 5 6 29
GSE54993 ARL2 402 3 0 67
GSE54994 ARL2 402 6 5 42
GSE60625 ARL2 402 0 3 8
GSE74703 ARL2 402 2 1 33
GSE74704 ARL2 402 5 4 11
TCGA ARL2 402 23 7 66

Total number of gains: 70; Total number of losses: 45; Total Number of normals: 373.  

 

Somatic mutations of ARL2:

 

Generating mutation plots.

 

Highly correlated genes for ARL2:

 

Showing top 20/872 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ARL2INTS30.782851303
ARL2UPF10.764644303
ARL2GAA0.761784303
ARL2GAS2L10.761602303
ARL2AKT30.752274303
ARL2RAB340.742751303
ARL2MTX10.739805404
ARL2ZNF7470.72818404
ARL2PPP1R350.725491404
ARL2RBM180.72367303
ARL2FAM86C10.723388505
ARL2MAP2K50.719458404
ARL2HSD17B110.716924404
ARL2LRRC140.716217303
ARL2PDK20.702032303
ARL2EP3000.701676303
ARL2ATXN1L0.701167303
ARL2CTF10.70064403
ARL2PSMD70.694255303
ARL2CCDC85B0.69418812011

For details and further investigation, click here