Full name: phosphoinositide-3-kinase regulatory subunit 3	Alias Symbol: p55
Type: protein-coding gene	Cytoband: 1p34.1
Entrez ID: 8503	HGNC ID: HGNC:8981	Ensembl Gene: ENSG00000117461	OMIM ID: 606076
Drug and gene relationship at DGIdb

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PIK3R3 involved pathways:

KEGG pathway	Description	View
hsa04012	ErbB signaling pathway	View
hsa04014	Ras signaling pathway	View
hsa04015	Rap1 signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04024	cAMP signaling pathway	View
hsa04062	Chemokine signaling pathway	View
hsa04066	HIF-1 signaling pathway	View
hsa04068	FoxO signaling pathway	View
hsa04071	Sphingolipid signaling pathway	View
hsa04072	Phospholipase D signaling pathway	View
hsa04150	mTOR signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04152	AMPK signaling pathway	View
hsa04210	Apoptosis	View
hsa04211	Longevity regulating pathway - mammal	View
hsa04213	Longevity regulating pathway - multiple species	View
hsa04261	Adrenergic signaling in cardiomyocytes	View
hsa04360	Axon guidance	View
hsa04370	VEGF signaling pathway	View
hsa04380	Osteoclast differentiation	View
hsa04510	Focal adhesion	View
hsa04550	Signaling pathways regulating pluripotency of stem cells	View
hsa04611	Platelet activation	View
hsa04620	Toll-like receptor signaling pathway	View
hsa04630	Jak-STAT signaling pathway	View
hsa04650	Natural killer cell mediated cytotoxicity	View
hsa04660	T cell receptor signaling pathway	View
hsa04662	B cell receptor signaling pathway	View
hsa04664	Fc epsilon RI signaling pathway	View
hsa04666	Fc gamma R-mediated phagocytosis	View
hsa04668	TNF signaling pathway	View
hsa04670	Leukocyte transendothelial migration	View
hsa04722	Neurotrophin signaling pathway	View
hsa04725	Cholinergic synapse	View
hsa04750	Inflammatory mediator regulation of TRP channels	View
hsa04810	Regulation of actin cytoskeleton	View
hsa04910	Insulin signaling pathway	View
hsa04914	Progesterone-mediated oocyte maturation	View
hsa04915	Estrogen signaling pathway	View
hsa04917	Prolactin signaling pathway	View
hsa04919	Thyroid hormone signaling pathway	View
hsa04921	Oxytocin signaling pathway	View
hsa04923	Regulation of lipolysis in adipocytes	View
hsa04930	Type II diabetes mellitus	View
hsa04931	Insulin resistance	View
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	View
hsa04933	AGE-RAGE signaling pathway in diabetic complications	View
hsa04960	Aldosterone-regulated sodium reabsorption	View
hsa04973	Carbohydrate digestion and absorption	View
hsa05100	Bacterial invasion of epithelial cells	View
hsa05142	Chagas disease (American trypanosomiasis)	View
hsa05145	Toxoplasmosis	View
hsa05160	Hepatitis C	View
hsa05161	Hepatitis B	View
hsa05162	Measles	View
hsa05164	Influenza A	View
hsa05166	HTLV-I infection	View
hsa05169	Epstein-Barr virus infection	View
hsa05200	Pathways in cancer	View
hsa05205	Proteoglycans in cancer	View
hsa05210	Colorectal cancer	View
hsa05211	Renal cell carcinoma	View
hsa05212	Pancreatic cancer	View
hsa05213	Endometrial cancer	View
hsa05214	Glioma	View
hsa05215	Prostate cancer	View
hsa05218	Melanoma	View
hsa05220	Chronic myeloid leukemia	View
hsa05221	Acute myeloid leukemia	View
hsa05222	Small cell lung cancer	View
hsa05223	Non-small cell lung cancer	View
hsa05231	Choline metabolism in cancer	View

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Expression of PIK3R3:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	PIK3R3	8503	202743_at	0.4883	0.5623	Show
GSE20347	PIK3R3	8503	202743_at	0.8299	0.0024	Show
GSE23400	PIK3R3	8503	202743_at	0.0433	0.7392	Show
GSE26886	PIK3R3	8503	202743_at	1.2990	0.0001	Show
GSE29001	PIK3R3	8503	202743_at	0.5246	0.0938	Show
GSE38129	PIK3R3	8503	202743_at	0.4447	0.1057	Show
GSE45670	PIK3R3	8503	202743_at	0.3670	0.2967	Show
GSE63941	PIK3R3	8503	202743_at	-0.2479	0.8338	Show
GSE77861	PIK3R3	8503	202743_at	0.5763	0.1366	Show
GSE97050	PIK3R3	8503	A_33_P3593774	0.2712	0.4881	Show
SRP007169	PIK3R3	8503	RNAseq	1.5812	0.0001	Show
SRP008496	PIK3R3	8503	RNAseq	1.9005	0.0000	Show
SRP064894	PIK3R3	8503	RNAseq	0.4772	0.0600	Show
SRP133303	PIK3R3	8503	RNAseq	0.4337	0.1435	Show
SRP159526	PIK3R3	8503	RNAseq	0.6790	0.0635	Show
SRP193095	PIK3R3	8503	RNAseq	1.0846	0.0000	Show
SRP219564	PIK3R3	8503	RNAseq	0.1453	0.7809	Show
TCGA	PIK3R3	8503	RNAseq	-0.3138	0.0021	Show

Upregulated datasets: 4; Downregulated datasets: 0.  Download Data

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Survival by PIK3R3 expression:

 

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Copy number change of PIK3R3:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	PIK3R3	8503	4	3	23	Show
GSE20123	PIK3R3	8503	4	2	24	Show
GSE43470	PIK3R3	8503	5	2	36	Show
GSE46452	PIK3R3	8503	2	1	56	Show
GSE47630	PIK3R3	8503	8	4	28	Show
GSE54993	PIK3R3	8503	0	1	69	Show
GSE54994	PIK3R3	8503	11	2	40	Show
GSE60625	PIK3R3	8503	0	0	11	Show
GSE74703	PIK3R3	8503	4	1	31	Show
GSE74704	PIK3R3	8503	2	0	18	Show
TCGA	PIK3R3	8503	10	17	69	Show

Total number of gains: 50; Total number of losses: 33; Total Number of normals: 405.  Download Data

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Somatic mutations of PIK3R3:

 

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Highly correlated genes for PIK3R3:

 

Showing top 20/1000 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
PIK3R3	SLCO3A1	0.853923	3	0	3
PIK3R3	THEM4	0.8269	3	0	3
PIK3R3	RNF138	0.809753	3	0	3
PIK3R3	SPEN	0.807963	3	0	3
PIK3R3	MSTO1	0.805919	3	0	3
PIK3R3	C1orf131	0.803519	3	0	3
PIK3R3	ZNF397	0.784321	3	0	3
PIK3R3	LEMD2	0.78425	3	0	3
PIK3R3	HIBADH	0.781099	3	0	3
PIK3R3	GLCCI1	0.780275	3	0	3
PIK3R3	APOO	0.779254	3	0	3
PIK3R3	COMMD7	0.778698	3	0	3
PIK3R3	TRMT6	0.775001	3	0	3
PIK3R3	ZHX2	0.774925	3	0	3
PIK3R3	ZNF317	0.774202	3	0	3
PIK3R3	CXXC1	0.769121	3	0	3
PIK3R3	TBCC	0.766658	3	0	3
PIK3R3	CHCHD6	0.76593	3	0	3
PIK3R3	SLC25A19	0.765617	3	0	3
PIK3R3	YDJC	0.764472	3	0	3

For details and further investigation, click here