| Full name: spermatogenesis associated 5 | Alias Symbol: SPAF|AFG2 | ||
| Type: protein-coding gene | Cytoband: 4q28.1 | ||
| Entrez ID: 166378 | HGNC ID: HGNC:18119 | Ensembl Gene: ENSG00000145375 | OMIM ID: 613940 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPATA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPATA5 | 166378 | 229075_at | 0.8013 | 0.0993 | |
| GSE26886 | SPATA5 | 166378 | 229075_at | 0.6391 | 0.0989 | |
| GSE45670 | SPATA5 | 166378 | 229075_at | 0.5543 | 0.0080 | |
| GSE53622 | SPATA5 | 166378 | 614 | 0.1767 | 0.1540 | |
| GSE53624 | SPATA5 | 166378 | 614 | 0.7427 | 0.0000 | |
| GSE63941 | SPATA5 | 166378 | 229075_at | 0.1698 | 0.7691 | |
| GSE77861 | SPATA5 | 166378 | 241546_at | -0.0241 | 0.7838 | |
| GSE97050 | SPATA5 | 166378 | A_33_P3268224 | 0.0412 | 0.9162 | |
| SRP007169 | SPATA5 | 166378 | RNAseq | 1.1003 | 0.0060 | |
| SRP008496 | SPATA5 | 166378 | RNAseq | 1.1328 | 0.0000 | |
| SRP064894 | SPATA5 | 166378 | RNAseq | 0.5505 | 0.0017 | |
| SRP133303 | SPATA5 | 166378 | RNAseq | 0.5742 | 0.0002 | |
| SRP159526 | SPATA5 | 166378 | RNAseq | 0.6371 | 0.1064 | |
| SRP193095 | SPATA5 | 166378 | RNAseq | 0.4177 | 0.0000 | |
| SRP219564 | SPATA5 | 166378 | RNAseq | 0.4123 | 0.1917 | |
| TCGA | SPATA5 | 166378 | RNAseq | 0.1671 | 0.0144 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SPATA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPATA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPATA5 | 166378 | 0 | 13 | 17 | |
| GSE20123 | SPATA5 | 166378 | 0 | 13 | 17 | |
| GSE43470 | SPATA5 | 166378 | 0 | 13 | 30 | |
| GSE46452 | SPATA5 | 166378 | 1 | 36 | 22 | |
| GSE47630 | SPATA5 | 166378 | 0 | 22 | 18 | |
| GSE54993 | SPATA5 | 166378 | 9 | 0 | 61 | |
| GSE54994 | SPATA5 | 166378 | 1 | 10 | 42 | |
| GSE60625 | SPATA5 | 166378 | 0 | 1 | 10 | |
| GSE74703 | SPATA5 | 166378 | 0 | 11 | 25 | |
| GSE74704 | SPATA5 | 166378 | 0 | 7 | 13 | |
| TCGA | SPATA5 | 166378 | 8 | 35 | 53 |
Total number of gains: 19; Total number of losses: 161; Total Number of normals: 308.
Somatic mutations of SPATA5:
Generating mutation plots.
Highly correlated genes for SPATA5:
Showing top 20/773 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPATA5 | IRF2BPL | 0.7915 | 3 | 0 | 3 |
| SPATA5 | CCT6A | 0.770602 | 3 | 0 | 3 |
| SPATA5 | TRAF3 | 0.77059 | 3 | 0 | 3 |
| SPATA5 | UTP20 | 0.75381 | 3 | 0 | 3 |
| SPATA5 | MTX1 | 0.746414 | 3 | 0 | 3 |
| SPATA5 | HNRNPC | 0.743095 | 3 | 0 | 3 |
| SPATA5 | MGAT2 | 0.738174 | 3 | 0 | 3 |
| SPATA5 | DOLK | 0.737241 | 3 | 0 | 3 |
| SPATA5 | C6orf141 | 0.730028 | 3 | 0 | 3 |
| SPATA5 | TOP3A | 0.729412 | 4 | 0 | 4 |
| SPATA5 | VOPP1 | 0.728317 | 4 | 0 | 4 |
| SPATA5 | ZNF484 | 0.728216 | 3 | 0 | 3 |
| SPATA5 | ADAT1 | 0.720797 | 5 | 0 | 5 |
| SPATA5 | TNFRSF21 | 0.720337 | 3 | 0 | 3 |
| SPATA5 | CHST12 | 0.716493 | 3 | 0 | 3 |
| SPATA5 | RBBP5 | 0.716283 | 3 | 0 | 3 |
| SPATA5 | RRM2B | 0.715293 | 4 | 0 | 3 |
| SPATA5 | NFS1 | 0.714974 | 3 | 0 | 3 |
| SPATA5 | RCN2 | 0.711413 | 3 | 0 | 3 |
| SPATA5 | POLR1B | 0.709878 | 3 | 0 | 3 |
For details and further investigation, click here
