| Full name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18q21.31 | ||
| Entrez ID: 51046 | HGNC ID: HGNC:14269 | Ensembl Gene: ENSG00000177511 | OMIM ID: 609478 |
| Drug and gene relationship at DGIdb | |||
Expression of ST8SIA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ST8SIA3 | 51046 | 230262_at | 0.0189 | 0.9591 | |
| GSE20347 | ST8SIA3 | 51046 | 208064_s_at | -0.0119 | 0.8516 | |
| GSE23400 | ST8SIA3 | 51046 | 208064_s_at | -0.0198 | 0.5253 | |
| GSE26886 | ST8SIA3 | 51046 | 230262_at | -0.1718 | 0.2452 | |
| GSE29001 | ST8SIA3 | 51046 | 208064_s_at | -0.1863 | 0.1749 | |
| GSE38129 | ST8SIA3 | 51046 | 208064_s_at | -0.0300 | 0.6579 | |
| GSE45670 | ST8SIA3 | 51046 | 230262_at | 0.1396 | 0.0808 | |
| GSE53622 | ST8SIA3 | 51046 | 75287 | 0.4250 | 0.0000 | |
| GSE53624 | ST8SIA3 | 51046 | 75287 | 0.3727 | 0.0004 | |
| GSE63941 | ST8SIA3 | 51046 | 230262_at | -0.0519 | 0.8103 | |
| GSE77861 | ST8SIA3 | 51046 | 230262_at | -0.1062 | 0.3260 | |
| GSE97050 | ST8SIA3 | 51046 | A_32_P154021 | 0.0162 | 0.9533 | |
| TCGA | ST8SIA3 | 51046 | RNAseq | -5.8563 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ST8SIA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ST8SIA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ST8SIA3 | 51046 | 2 | 9 | 19 | |
| GSE20123 | ST8SIA3 | 51046 | 2 | 9 | 19 | |
| GSE43470 | ST8SIA3 | 51046 | 0 | 5 | 38 | |
| GSE46452 | ST8SIA3 | 51046 | 1 | 26 | 32 | |
| GSE47630 | ST8SIA3 | 51046 | 5 | 20 | 15 | |
| GSE54993 | ST8SIA3 | 51046 | 10 | 0 | 60 | |
| GSE54994 | ST8SIA3 | 51046 | 0 | 18 | 35 | |
| GSE60625 | ST8SIA3 | 51046 | 0 | 4 | 7 | |
| GSE74703 | ST8SIA3 | 51046 | 0 | 5 | 31 | |
| GSE74704 | ST8SIA3 | 51046 | 2 | 6 | 12 | |
| TCGA | ST8SIA3 | 51046 | 9 | 44 | 43 |
Total number of gains: 31; Total number of losses: 146; Total Number of normals: 311.
Somatic mutations of ST8SIA3:
Generating mutation plots.
Highly correlated genes for ST8SIA3:
Showing top 20/831 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ST8SIA3 | KRTAP10-12 | 0.838111 | 3 | 0 | 3 |
| ST8SIA3 | OR2A5 | 0.824704 | 3 | 0 | 3 |
| ST8SIA3 | PLA2G2C | 0.809536 | 3 | 0 | 3 |
| ST8SIA3 | OR2T1 | 0.800941 | 3 | 0 | 3 |
| ST8SIA3 | YY2 | 0.800717 | 3 | 0 | 3 |
| ST8SIA3 | FAM181A | 0.797323 | 3 | 0 | 3 |
| ST8SIA3 | DCDC1 | 0.795372 | 3 | 0 | 3 |
| ST8SIA3 | OR2T27 | 0.789717 | 3 | 0 | 3 |
| ST8SIA3 | BLACE | 0.785719 | 3 | 0 | 3 |
| ST8SIA3 | STRC | 0.785159 | 3 | 0 | 3 |
| ST8SIA3 | SIGLEC11 | 0.781719 | 3 | 0 | 3 |
| ST8SIA3 | MS4A18 | 0.781042 | 3 | 0 | 3 |
| ST8SIA3 | RASL10B | 0.777399 | 3 | 0 | 3 |
| ST8SIA3 | PSMB11 | 0.7767 | 3 | 0 | 3 |
| ST8SIA3 | C9orf153 | 0.775036 | 3 | 0 | 3 |
| ST8SIA3 | PRSS38 | 0.774026 | 3 | 0 | 3 |
| ST8SIA3 | LRRC71 | 0.773693 | 3 | 0 | 3 |
| ST8SIA3 | CDX2 | 0.769109 | 3 | 0 | 3 |
| ST8SIA3 | PAX6 | 0.762745 | 3 | 0 | 3 |
| ST8SIA3 | OTOG | 0.758831 | 3 | 0 | 3 |
For details and further investigation, click here
