MAPK11

 

Full name: mitogen-activated protein kinase 11 Alias Symbol: p38-2|p38Beta|SAPK2
Type: protein-coding gene Cytoband: 22q13.33
Entrez ID: 5600 HGNC ID: HGNC:6873 Ensembl Gene: ENSG00000185386 OMIM ID: 602898
Drug and gene relationship at DGIdb

 

MAPK11 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04015Rap1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04668TNF signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04728Dopaminergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04917Prolactin signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05132Salmonella infection
hsa05133Pertussis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05164Influenza A
hsa05169Epstein-Barr virus infection
hsa05205Proteoglycans in cancer

 

Expression of MAPK11:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAPK11 5600 211499_s_at 0.3220 0.4459
GSE20347 MAPK11 5600 211500_at -0.0236 0.8047
GSE23400 MAPK11 5600 211500_at 0.0914 0.0292
GSE26886 MAPK11 5600 211500_at 0.0630 0.6337
GSE29001 MAPK11 5600 211500_at 0.0774 0.7545
GSE38129 MAPK11 5600 211500_at 0.0007 0.9938
GSE45670 MAPK11 5600 211499_s_at 0.2179 0.1043
GSE53622 MAPK11 5600 54836 0.2668 0.0021
GSE53624 MAPK11 5600 31016 0.7829 0.0000
GSE63941 MAPK11 5600 211500_at -0.0288 0.8967
GSE77861 MAPK11 5600 211500_at -0.1708 0.1930
GSE97050 MAPK11 5600 A_33_P3409513 0.3780 0.2359
SRP007169 MAPK11 5600 RNAseq 0.4238 0.4144
SRP008496 MAPK11 5600 RNAseq 0.8741 0.0646
SRP064894 MAPK11 5600 RNAseq 1.5778 0.0000
SRP133303 MAPK11 5600 RNAseq 0.1490 0.4951
SRP159526 MAPK11 5600 RNAseq 0.4766 0.0965
SRP193095 MAPK11 5600 RNAseq 1.1780 0.0000
SRP219564 MAPK11 5600 RNAseq 0.8399 0.0582
TCGA MAPK11 5600 RNAseq 0.1865 0.1175

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by MAPK11 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAPK11:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAPK11 5600 3 8 19
GSE20123 MAPK11 5600 3 8 19
GSE43470 MAPK11 5600 2 8 33
GSE46452 MAPK11 5600 31 2 26
GSE47630 MAPK11 5600 9 4 27
GSE54993 MAPK11 5600 4 6 60
GSE54994 MAPK11 5600 11 8 34
GSE60625 MAPK11 5600 5 0 6
GSE74703 MAPK11 5600 2 6 28
GSE74704 MAPK11 5600 1 4 15
TCGA MAPK11 5600 26 16 54

Total number of gains: 97; Total number of losses: 70; Total Number of normals: 321.  

 

Somatic mutations of MAPK11:

 

Generating mutation plots.

 

Highly correlated genes for MAPK11:

 

Showing top 20/587 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAPK11FOXRED20.829527303
MAPK11ARTN0.776952303
MAPK11LGI20.771999404
MAPK11TNFSF80.770936303
MAPK11HHLA10.767828303
MAPK11RNASE30.766899303
MAPK11INO80B0.765696303
MAPK11MYBPC30.763575303
MAPK11LIPF0.760849303
MAPK11GDF50.754037303
MAPK11KCNK20.753228303
MAPK11TAS2R40.75061303
MAPK11PFKL0.747756303
MAPK11CEP1280.737259303
MAPK11POLD40.729556303
MAPK11CDH70.727128404
MAPK11ATOX10.724556303
MAPK11PLCB20.723211403
MAPK11LZTS10.722988403
MAPK11SHB0.722929303

For details and further investigation, click here