GRIN2D

 

Full name: glutamate ionotropic receptor NMDA type subunit 2D Alias Symbol: GluN2D|EB11|NR2D
Type: protein-coding gene Cytoband: 19q13.33
Entrez ID: 2906 HGNC ID: HGNC:4588 Ensembl Gene: ENSG00000105464 OMIM ID: 602717
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

GRIN2D involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04724Glutamatergic synapse
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism

 

Expression of GRIN2D:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GRIN2D 2906 229883_at 0.9487 0.4399
GSE20347 GRIN2D 2906 207036_x_at 0.0568 0.3318
GSE23400 GRIN2D 2906 207036_x_at -0.0807 0.0044
GSE26886 GRIN2D 2906 229883_at 0.4084 0.0125
GSE29001 GRIN2D 2906 207036_x_at -0.1330 0.2343
GSE38129 GRIN2D 2906 207036_x_at -0.0108 0.8557
GSE45670 GRIN2D 2906 229883_at 0.6215 0.0123
GSE53622 GRIN2D 2906 27037 3.0780 0.0000
GSE53624 GRIN2D 2906 27037 3.2013 0.0000
GSE63941 GRIN2D 2906 229883_at 1.1285 0.0582
GSE77861 GRIN2D 2906 229883_at 0.5527 0.1930
GSE97050 GRIN2D 2906 A_33_P3402868 0.4663 0.2324
SRP007169 GRIN2D 2906 RNAseq 6.6470 0.0000
SRP064894 GRIN2D 2906 RNAseq 4.1643 0.0000
SRP133303 GRIN2D 2906 RNAseq 2.9275 0.0000
SRP159526 GRIN2D 2906 RNAseq 3.7089 0.0000
SRP219564 GRIN2D 2906 RNAseq 3.6715 0.0000
TCGA GRIN2D 2906 RNAseq 1.3719 0.0000

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by GRIN2D expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GRIN2D:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GRIN2D 2906 4 4 22
GSE20123 GRIN2D 2906 4 3 23
GSE43470 GRIN2D 2906 4 11 28
GSE46452 GRIN2D 2906 45 1 13
GSE47630 GRIN2D 2906 9 6 25
GSE54993 GRIN2D 2906 17 4 49
GSE54994 GRIN2D 2906 4 14 35
GSE60625 GRIN2D 2906 9 0 2
GSE74703 GRIN2D 2906 4 7 25
GSE74704 GRIN2D 2906 4 1 15
TCGA GRIN2D 2906 15 18 63

Total number of gains: 119; Total number of losses: 69; Total Number of normals: 300.  

 

Somatic mutations of GRIN2D:

 

Generating mutation plots.

 

Highly correlated genes for GRIN2D:

 

Showing top 20/814 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GRIN2DARID20.8109303
GRIN2DTP53I110.80451404
GRIN2DINPP5B0.792065303
GRIN2DCAPN120.779585303
GRIN2DGABRR20.76505404
GRIN2DNCOA60.763519303
GRIN2DPOLRMT0.751662303
GRIN2DZNF7070.74396303
GRIN2DFIBCD10.736329303
GRIN2DXAB20.731671404
GRIN2DLINC013610.729216303
GRIN2DKTI120.720229303
GRIN2DMED250.713305404
GRIN2DEFCAB70.712443303
GRIN2DSLC43A20.712336404
GRIN2DRUNX1-IT10.709438303
GRIN2DRIT20.709275303
GRIN2DRGS30.709079404
GRIN2DSPON20.707105303
GRIN2DWDTC10.706935404

For details and further investigation, click here