| Full name: growth differentiation factor 10 | Alias Symbol: BMP-3b | ||
| Type: protein-coding gene | Cytoband: 10q11.22 | ||
| Entrez ID: 2662 | HGNC ID: HGNC:4215 | Ensembl Gene: ENSG00000266524 | OMIM ID: 601361 |
| Drug and gene relationship at DGIdb | |||
Expression of GDF10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GDF10 | 2662 | 206159_at | -0.7853 | 0.2189 | |
| GSE20347 | GDF10 | 2662 | 206159_at | -0.0367 | 0.5286 | |
| GSE23400 | GDF10 | 2662 | 206159_at | -0.1722 | 0.0000 | |
| GSE26886 | GDF10 | 2662 | 206159_at | 0.0227 | 0.8022 | |
| GSE29001 | GDF10 | 2662 | 206159_at | -0.1156 | 0.2992 | |
| GSE38129 | GDF10 | 2662 | 206159_at | -0.3501 | 0.0126 | |
| GSE45670 | GDF10 | 2662 | 206159_at | -0.2699 | 0.0017 | |
| GSE63941 | GDF10 | 2662 | 206159_at | -0.0138 | 0.9271 | |
| GSE77861 | GDF10 | 2662 | 206159_at | -0.0313 | 0.6607 | |
| SRP159526 | GDF10 | 2662 | RNAseq | -2.3645 | 0.0002 | |
| TCGA | GDF10 | 2662 | RNAseq | -2.2470 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GDF10 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GDF10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GDF10 | 2662 | 2 | 5 | 23 | |
| GSE20123 | GDF10 | 2662 | 2 | 5 | 23 | |
| GSE43470 | GDF10 | 2662 | 1 | 6 | 36 | |
| GSE46452 | GDF10 | 2662 | 0 | 13 | 46 | |
| GSE47630 | GDF10 | 2662 | 4 | 13 | 23 | |
| GSE54993 | GDF10 | 2662 | 9 | 0 | 61 | |
| GSE54994 | GDF10 | 2662 | 2 | 10 | 41 | |
| GSE60625 | GDF10 | 2662 | 0 | 0 | 11 | |
| GSE74703 | GDF10 | 2662 | 1 | 3 | 32 | |
| GSE74704 | GDF10 | 2662 | 1 | 4 | 15 | |
| TCGA | GDF10 | 2662 | 16 | 18 | 62 |
Total number of gains: 38; Total number of losses: 77; Total Number of normals: 373.
Somatic mutations of GDF10:
Generating mutation plots.
Highly correlated genes for GDF10:
Showing top 20/625 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GDF10 | ABCA6 | 0.775523 | 5 | 0 | 5 |
| GDF10 | CDO1 | 0.767665 | 3 | 0 | 3 |
| GDF10 | P2RX2 | 0.742628 | 4 | 0 | 4 |
| GDF10 | TIMP4 | 0.737403 | 6 | 0 | 6 |
| GDF10 | TAC1 | 0.731793 | 3 | 0 | 3 |
| GDF10 | FRRS1L | 0.729084 | 3 | 0 | 3 |
| GDF10 | MYBPC3 | 0.723285 | 3 | 0 | 3 |
| GDF10 | IBA57 | 0.710431 | 3 | 0 | 3 |
| GDF10 | NMNAT2 | 0.704674 | 3 | 0 | 3 |
| GDF10 | ACVRL1 | 0.703737 | 4 | 0 | 3 |
| GDF10 | PDC | 0.701618 | 3 | 0 | 3 |
| GDF10 | STXBP6 | 0.701453 | 5 | 0 | 5 |
| GDF10 | KLF9 | 0.697077 | 3 | 0 | 3 |
| GDF10 | APOLD1 | 0.693914 | 3 | 0 | 3 |
| GDF10 | USP2 | 0.68961 | 3 | 0 | 3 |
| GDF10 | FRY | 0.686637 | 3 | 0 | 3 |
| GDF10 | GFRA3 | 0.685554 | 5 | 0 | 5 |
| GDF10 | KCNN3 | 0.685502 | 3 | 0 | 3 |
| GDF10 | PHLDB1 | 0.684629 | 4 | 0 | 4 |
| GDF10 | AGTR1 | 0.681606 | 4 | 0 | 3 |
For details and further investigation, click here
