PFN3

 

Full name: profilin 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 5q35.3
Entrez ID: 345456 HGNC ID: HGNC:18627 Ensembl Gene: ENSG00000196570 OMIM ID: 612812
Drug and gene relationship at DGIdb

 

PFN3 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05132Salmonella infection

 

Expression of PFN3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 PFN3 345456 52385 0.3237 0.0000
GSE53624 PFN3 345456 52385 0.2532 0.0081
GSE97050 PFN3 345456 A_24_P49997 -0.1091 0.6223
TCGA PFN3 345456 RNAseq 0.3080 0.7588

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PFN3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PFN3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PFN3 345456 2 13 15
GSE20123 PFN3 345456 2 13 15
GSE43470 PFN3 345456 1 11 31
GSE46452 PFN3 345456 0 27 32
GSE47630 PFN3 345456 1 20 19
GSE54993 PFN3 345456 10 2 58
GSE54994 PFN3 345456 2 17 34
GSE60625 PFN3 345456 1 0 10
GSE74703 PFN3 345456 1 7 28
GSE74704 PFN3 345456 1 6 13
TCGA PFN3 345456 8 34 54

Total number of gains: 29; Total number of losses: 150; Total Number of normals: 309.  

 

Somatic mutations of PFN3:

 

Generating mutation plots.

 

Highly correlated genes for PFN3:

 

Showing all 13 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PFN3CYP11B10.745428303
PFN3LRFN40.695792303
PFN3CPNE70.685178303
PFN3SLC6A30.677858303
PFN3ATCAY0.671023303
PFN3ELOVL30.663057303
PFN3SLC22A110.650066303
PFN3NPM20.649236303
PFN3ATP2A10.635676303
PFN3ACAN0.622519303
PFN3LRRC710.597687303
PFN3SLC30A20.579591303
PFN3RHPN10.561222303

For details and further investigation, click here