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Multi-Omics Database of ESCC

 

ATP2A1

 

Full name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Alias Symbol: SERCA1
Type: protein-coding gene Cytoband: 16p11.2
Entrez ID: 487 HGNC ID: HGNC:811 Ensembl Gene: ENSG00000196296 OMIM ID: 108730
Drug and gene relationship at DGIdb

 

ATP2A1 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway

 

Expression of ATP2A1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ATP2A1 487 205444_at -0.0477 0.8905
GSE20347 ATP2A1 487 205444_at -0.0714 0.3014
GSE23400 ATP2A1 487 205444_at -0.0352 0.3931
GSE26886 ATP2A1 487 205444_at 0.4893 0.0004
GSE29001 ATP2A1 487 205444_at -0.2077 0.1319
GSE38129 ATP2A1 487 205444_at -0.0642 0.3919
GSE45670 ATP2A1 487 205444_at 0.0415 0.7071
GSE53622 ATP2A1 487 71646 0.5514 0.0000
GSE53624 ATP2A1 487 71646 0.5816 0.0000
GSE63941 ATP2A1 487 205444_at 0.5057 0.0025
GSE77861 ATP2A1 487 205444_at -0.1076 0.2797
GSE97050 ATP2A1 487 A_33_P3342830 -0.0687 0.8853
SRP064894 ATP2A1 487 RNAseq 0.7099 0.0214
SRP133303 ATP2A1 487 RNAseq 0.4568 0.2924
SRP159526 ATP2A1 487 RNAseq 2.2404 0.0007
SRP193095 ATP2A1 487 RNAseq 0.6727 0.0174
SRP219564 ATP2A1 487 RNAseq 0.4015 0.4665
TCGA ATP2A1 487 RNAseq 0.7542 0.0017

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ATP2A1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ATP2A1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ATP2A1 487 5 5 20
GSE20123 ATP2A1 487 5 4 21
GSE43470 ATP2A1 487 3 3 37
GSE46452 ATP2A1 487 38 1 20
GSE47630 ATP2A1 487 11 7 22
GSE54993 ATP2A1 487 3 5 62
GSE54994 ATP2A1 487 5 9 39
GSE60625 ATP2A1 487 4 0 7
GSE74703 ATP2A1 487 3 2 31
GSE74704 ATP2A1 487 3 2 15
TCGA ATP2A1 487 20 12 64

Total number of gains: 100; Total number of losses: 50; Total Number of normals: 338.  

 

Somatic mutations of ATP2A1:

 

Generating mutation plots.

 

Highly correlated genes for ATP2A1:

 

Showing top 20/879 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ATP2A1DEFB1280.81156303
ATP2A1MEP1B0.769486303
ATP2A1NKX6-30.757651404
ATP2A1TPH20.754629303
ATP2A1STRC0.750289303
ATP2A1OR2A50.74603303
ATP2A1OR2T270.745904303
ATP2A1PRAMEF120.745571404
ATP2A1RAB440.729221303
ATP2A1C9orf1530.72376303
ATP2A1DCDC10.723517303
ATP2A1ZNF8430.723239303
ATP2A1C19orf710.720664303
ATP2A1BBC30.719518303
ATP2A1SUN50.716076303
ATP2A1TAS2R310.712801303
ATP2A1BLACE0.711702303
ATP2A1MS4A180.709474303
ATP2A1KRTAP3-10.709445303
ATP2A1SHISA70.705368404

For details and further investigation, click here