| Full name: aggrecan | Alias Symbol: CSPGCP | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 176 | HGNC ID: HGNC:319 | Ensembl Gene: ENSG00000157766 | OMIM ID: 155760 |
| Drug and gene relationship at DGIdb | |||
Expression of ACAN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACAN | 176 | 217161_x_at | 0.1351 | 0.6913 | |
| GSE20347 | ACAN | 176 | 217161_x_at | -0.0173 | 0.8951 | |
| GSE23400 | ACAN | 176 | 205679_x_at | 0.0140 | 0.7821 | |
| GSE26886 | ACAN | 176 | 217161_x_at | 0.1685 | 0.1823 | |
| GSE29001 | ACAN | 176 | 205679_x_at | 0.1459 | 0.4056 | |
| GSE38129 | ACAN | 176 | 217161_x_at | 0.0541 | 0.6178 | |
| GSE45670 | ACAN | 176 | 217161_x_at | 0.1408 | 0.1500 | |
| GSE53622 | ACAN | 176 | 46131 | 0.7208 | 0.0000 | |
| GSE53624 | ACAN | 176 | 8198 | 0.4503 | 0.0044 | |
| GSE63941 | ACAN | 176 | 217161_x_at | 0.0551 | 0.8142 | |
| GSE77861 | ACAN | 176 | 217161_x_at | -0.0072 | 0.9496 | |
| GSE97050 | ACAN | 176 | A_33_P3500167 | 0.3188 | 0.3048 | |
| SRP007169 | ACAN | 176 | RNAseq | 5.2508 | 0.0005 | |
| SRP064894 | ACAN | 176 | RNAseq | 2.7494 | 0.0000 | |
| SRP133303 | ACAN | 176 | RNAseq | 1.4540 | 0.0004 | |
| SRP159526 | ACAN | 176 | RNAseq | 1.4162 | 0.1967 | |
| SRP219564 | ACAN | 176 | RNAseq | 1.9236 | 0.0061 | |
| TCGA | ACAN | 176 | RNAseq | 0.7201 | 0.0058 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ACAN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACAN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACAN | 176 | 7 | 3 | 20 | |
| GSE20123 | ACAN | 176 | 7 | 3 | 20 | |
| GSE43470 | ACAN | 176 | 5 | 4 | 34 | |
| GSE46452 | ACAN | 176 | 3 | 7 | 49 | |
| GSE47630 | ACAN | 176 | 8 | 11 | 21 | |
| GSE54993 | ACAN | 176 | 4 | 6 | 60 | |
| GSE54994 | ACAN | 176 | 7 | 6 | 40 | |
| GSE60625 | ACAN | 176 | 4 | 0 | 7 | |
| GSE74703 | ACAN | 176 | 4 | 3 | 29 | |
| GSE74704 | ACAN | 176 | 4 | 2 | 14 | |
| TCGA | ACAN | 176 | 17 | 11 | 68 |
Total number of gains: 70; Total number of losses: 56; Total Number of normals: 362.
Somatic mutations of ACAN:
Generating mutation plots.
Highly correlated genes for ACAN:
Showing top 20/578 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACAN | MS4A18 | 0.751889 | 3 | 0 | 3 |
| ACAN | IFNL2 | 0.73794 | 3 | 0 | 3 |
| ACAN | ELOVL3 | 0.730479 | 3 | 0 | 3 |
| ACAN | PTK2B | 0.729058 | 4 | 0 | 4 |
| ACAN | PSMB11 | 0.725427 | 3 | 0 | 3 |
| ACAN | CSMD2 | 0.72179 | 3 | 0 | 3 |
| ACAN | PNPLA7 | 0.714374 | 3 | 0 | 3 |
| ACAN | TMEM105 | 0.713727 | 4 | 0 | 4 |
| ACAN | LRRC10 | 0.713437 | 3 | 0 | 3 |
| ACAN | RBM28 | 0.705594 | 3 | 0 | 3 |
| ACAN | NKX6-3 | 0.705586 | 4 | 0 | 4 |
| ACAN | MEGF11 | 0.704787 | 4 | 0 | 4 |
| ACAN | TMEM235 | 0.699703 | 4 | 0 | 4 |
| ACAN | PLA2G2C | 0.697676 | 3 | 0 | 3 |
| ACAN | GPSM3 | 0.697379 | 3 | 0 | 3 |
| ACAN | LHB | 0.697275 | 3 | 0 | 3 |
| ACAN | LINC01101 | 0.693979 | 3 | 0 | 3 |
| ACAN | TPH2 | 0.692106 | 4 | 0 | 4 |
| ACAN | DCDC1 | 0.686437 | 3 | 0 | 3 |
| ACAN | STRC | 0.683544 | 3 | 0 | 3 |
For details and further investigation, click here
