| Full name: solute carrier family 6 member 3 | Alias Symbol: DAT | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 6531 | HGNC ID: HGNC:11049 | Ensembl Gene: ENSG00000142319 | OMIM ID: 126455 |
| Drug and gene relationship at DGIdb | |||
SLC6A3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04728 | Dopaminergic synapse | |
| hsa05030 | Cocaine addiction | |
| hsa05031 | Amphetamine addiction |
Expression of SLC6A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC6A3 | 6531 | 206836_at | 0.0841 | 0.7870 | |
| GSE20347 | SLC6A3 | 6531 | 206836_at | 0.0367 | 0.6873 | |
| GSE23400 | SLC6A3 | 6531 | 206836_at | -0.0499 | 0.2025 | |
| GSE26886 | SLC6A3 | 6531 | 206836_at | 0.4096 | 0.0162 | |
| GSE29001 | SLC6A3 | 6531 | 206836_at | 0.1184 | 0.4846 | |
| GSE38129 | SLC6A3 | 6531 | 206836_at | 0.1292 | 0.1837 | |
| GSE45670 | SLC6A3 | 6531 | 206836_at | 0.1361 | 0.1562 | |
| GSE53622 | SLC6A3 | 6531 | 49753 | 0.6217 | 0.0000 | |
| GSE53624 | SLC6A3 | 6531 | 49753 | 0.3755 | 0.0000 | |
| GSE63941 | SLC6A3 | 6531 | 206836_at | 0.1281 | 0.4823 | |
| GSE77861 | SLC6A3 | 6531 | 206836_at | 0.0266 | 0.8711 | |
| GSE97050 | SLC6A3 | 6531 | A_33_P3303772 | 0.2596 | 0.2589 | |
| TCGA | SLC6A3 | 6531 | RNAseq | 1.5826 | 0.0937 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SLC6A3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC6A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC6A3 | 6531 | 13 | 1 | 16 | |
| GSE20123 | SLC6A3 | 6531 | 13 | 1 | 16 | |
| GSE43470 | SLC6A3 | 6531 | 17 | 1 | 25 | |
| GSE46452 | SLC6A3 | 6531 | 6 | 22 | 31 | |
| GSE47630 | SLC6A3 | 6531 | 7 | 11 | 22 | |
| GSE54993 | SLC6A3 | 6531 | 5 | 5 | 60 | |
| GSE54994 | SLC6A3 | 6531 | 29 | 1 | 23 | |
| GSE60625 | SLC6A3 | 6531 | 0 | 0 | 11 | |
| GSE74703 | SLC6A3 | 6531 | 14 | 0 | 22 | |
| GSE74704 | SLC6A3 | 6531 | 11 | 0 | 9 | |
| TCGA | SLC6A3 | 6531 | 60 | 3 | 33 |
Total number of gains: 175; Total number of losses: 45; Total Number of normals: 268.
Somatic mutations of SLC6A3:
Generating mutation plots.
Highly correlated genes for SLC6A3:
Showing top 20/967 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC6A3 | MEGF11 | 0.878708 | 3 | 0 | 3 |
| SLC6A3 | STRC | 0.853772 | 3 | 0 | 3 |
| SLC6A3 | MRGPRG | 0.853273 | 3 | 0 | 3 |
| SLC6A3 | C2CD4D | 0.84039 | 3 | 0 | 3 |
| SLC6A3 | DCDC1 | 0.839903 | 3 | 0 | 3 |
| SLC6A3 | LHB | 0.837536 | 3 | 0 | 3 |
| SLC6A3 | MS4A18 | 0.83594 | 3 | 0 | 3 |
| SLC6A3 | C9orf153 | 0.834976 | 3 | 0 | 3 |
| SLC6A3 | RASL10B | 0.828789 | 4 | 0 | 4 |
| SLC6A3 | NTNG2 | 0.827314 | 4 | 0 | 4 |
| SLC6A3 | POM121L12 | 0.823583 | 3 | 0 | 3 |
| SLC6A3 | C4BPA | 0.818847 | 3 | 0 | 3 |
| SLC6A3 | PLA2G2C | 0.809409 | 3 | 0 | 3 |
| SLC6A3 | RAX2 | 0.807837 | 3 | 0 | 3 |
| SLC6A3 | C19orf71 | 0.807018 | 3 | 0 | 3 |
| SLC6A3 | OR2C3 | 0.805666 | 3 | 0 | 3 |
| SLC6A3 | C1QL2 | 0.799827 | 3 | 0 | 3 |
| SLC6A3 | IGSF9B | 0.79893 | 3 | 0 | 3 |
| SLC6A3 | ANKDD1A | 0.795532 | 3 | 0 | 3 |
| SLC6A3 | CD72 | 0.792746 | 3 | 0 | 3 |
For details and further investigation, click here
