NPM2

 

Full name: nucleophosmin/nucleoplasmin 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 8p21.3
Entrez ID: 10361 HGNC ID: HGNC:7930 Ensembl Gene: ENSG00000158806 OMIM ID: 608073
Drug and gene relationship at DGIdb

 

Expression of NPM2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NPM2 10361 230977_at 0.0071 0.9826
GSE26886 NPM2 10361 230977_at 0.4087 0.0056
GSE45670 NPM2 10361 230977_at 0.1399 0.1423
GSE53622 NPM2 10361 56899 0.9210 0.0000
GSE53624 NPM2 10361 56899 0.6886 0.0000
GSE63941 NPM2 10361 230977_at 0.3482 0.1075
GSE77861 NPM2 10361 230977_at 0.1164 0.2804
GSE97050 NPM2 10361 A_33_P3272479 0.2597 0.2947
TCGA NPM2 10361 RNAseq 0.7736 0.0935

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NPM2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NPM2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NPM2 10361 4 10 16
GSE20123 NPM2 10361 4 10 16
GSE43470 NPM2 10361 4 9 30
GSE46452 NPM2 10361 13 13 33
GSE47630 NPM2 10361 10 8 22
GSE54993 NPM2 10361 2 14 54
GSE54994 NPM2 10361 8 18 27
GSE60625 NPM2 10361 3 0 8
GSE74703 NPM2 10361 4 7 25
GSE74704 NPM2 10361 3 7 10
TCGA NPM2 10361 13 43 40

Total number of gains: 68; Total number of losses: 139; Total Number of normals: 281.  

 

Somatic mutations of NPM2:

 

Generating mutation plots.

 

Highly correlated genes for NPM2:

 

Showing top 20/389 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NPM2CALCA0.795448303
NPM2FOXB10.793463303
NPM2C9orf1310.763278303
NPM2MS4A180.758745303
NPM2RFX80.744172303
NPM2RNF1860.743341303
NPM2COL20A10.743296303
NPM2PPP1R3F0.729991303
NPM2SORCS30.72698303
NPM2COL27A10.724871404
NPM2FXYD20.723704303
NPM2PSMB110.722534303
NPM2MRGPRG0.721845303
NPM2C2CD4D0.721803303
NPM2KLK30.721107404
NPM2COPS7B0.718916303
NPM2HSD17B140.7152303
NPM2SALL40.713764404
NPM2PCSK40.713622403
NPM2KCNF10.712584303

For details and further investigation, click here