| Full name: PKHD1 ciliary IPT domain containing fibrocystin/polyductin | Alias Symbol: ARPKD|FCYT|FPC | ||
| Type: protein-coding gene | Cytoband: 6p12.3-p12.2 | ||
| Entrez ID: 5314 | HGNC ID: HGNC:9016 | Ensembl Gene: ENSG00000170927 | OMIM ID: 606702 |
| Drug and gene relationship at DGIdb | |||
Expression of PKHD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKHD1 | 5314 | 1553003_at | -0.1269 | 0.6391 | |
| GSE26886 | PKHD1 | 5314 | 244410_at | 0.0038 | 0.9813 | |
| GSE45670 | PKHD1 | 5314 | 244410_at | -0.0215 | 0.8115 | |
| GSE53622 | PKHD1 | 5314 | 111507 | 0.9177 | 0.0000 | |
| GSE53624 | PKHD1 | 5314 | 111507 | 0.7518 | 0.0000 | |
| GSE63941 | PKHD1 | 5314 | 1553003_at | 0.1107 | 0.4081 | |
| GSE77861 | PKHD1 | 5314 | 244410_at | -0.1346 | 0.2738 | |
| SRP133303 | PKHD1 | 5314 | RNAseq | 0.1332 | 0.5246 | |
| SRP193095 | PKHD1 | 5314 | RNAseq | -0.5361 | 0.1332 | |
| TCGA | PKHD1 | 5314 | RNAseq | -1.1862 | 0.0971 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PKHD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKHD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKHD1 | 5314 | 7 | 2 | 21 | |
| GSE20123 | PKHD1 | 5314 | 8 | 2 | 20 | |
| GSE43470 | PKHD1 | 5314 | 5 | 0 | 38 | |
| GSE46452 | PKHD1 | 5314 | 3 | 10 | 46 | |
| GSE47630 | PKHD1 | 5314 | 7 | 5 | 28 | |
| GSE54993 | PKHD1 | 5314 | 3 | 1 | 66 | |
| GSE54994 | PKHD1 | 5314 | 8 | 4 | 41 | |
| GSE60625 | PKHD1 | 5314 | 0 | 3 | 8 | |
| GSE74703 | PKHD1 | 5314 | 5 | 0 | 31 | |
| GSE74704 | PKHD1 | 5314 | 4 | 1 | 15 | |
| TCGA | PKHD1 | 5314 | 25 | 11 | 60 |
Total number of gains: 75; Total number of losses: 39; Total Number of normals: 374.
Somatic mutations of PKHD1:
Generating mutation plots.
Highly correlated genes for PKHD1:
Showing all 13 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKHD1 | LINC01255 | 0.701153 | 3 | 0 | 3 |
| PKHD1 | DPEP1 | 0.654664 | 3 | 0 | 3 |
| PKHD1 | OR5H1 | 0.641207 | 3 | 0 | 3 |
| PKHD1 | CD244 | 0.640307 | 3 | 0 | 3 |
| PKHD1 | SNORA68 | 0.607065 | 3 | 0 | 3 |
| PKHD1 | APOA5 | 0.589409 | 3 | 0 | 3 |
| PKHD1 | CASC18 | 0.569995 | 3 | 0 | 3 |
| PKHD1 | BCKDHA | 0.562656 | 3 | 0 | 3 |
| PKHD1 | KRTAP5-8 | 0.557641 | 3 | 0 | 3 |
| PKHD1 | FGB | 0.550595 | 4 | 0 | 3 |
| PKHD1 | MYRF | 0.545737 | 3 | 0 | 3 |
| PKHD1 | CLVS1 | 0.543235 | 4 | 0 | 3 |
| PKHD1 | MED25 | 0.510587 | 3 | 0 | 3 |
For details and further investigation, click here
