| Full name: fibrinogen beta chain | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q31.3 | ||
| Entrez ID: 2244 | HGNC ID: HGNC:3662 | Ensembl Gene: ENSG00000171564 | OMIM ID: 134830 |
| Drug and gene relationship at DGIdb | |||
FGB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades | |
| hsa04611 | Platelet activation |
Expression of FGB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGB | 2244 | 204988_at | 0.0236 | 0.9432 | |
| GSE20347 | FGB | 2244 | 204988_at | -0.0356 | 0.5945 | |
| GSE23400 | FGB | 2244 | 204988_at | -0.0459 | 0.1718 | |
| GSE26886 | FGB | 2244 | 204988_at | 0.4257 | 0.2470 | |
| GSE29001 | FGB | 2244 | 204988_at | -0.1106 | 0.5961 | |
| GSE38129 | FGB | 2244 | 204988_at | -0.0874 | 0.3697 | |
| GSE45670 | FGB | 2244 | 204988_at | 0.1542 | 0.5583 | |
| GSE53622 | FGB | 2244 | 69136 | 0.2769 | 0.1739 | |
| GSE53624 | FGB | 2244 | 69136 | 0.5034 | 0.0098 | |
| GSE63941 | FGB | 2244 | 204988_at | 0.1131 | 0.3731 | |
| GSE77861 | FGB | 2244 | 204988_at | -0.0524 | 0.6355 | |
| TCGA | FGB | 2244 | RNAseq | -2.9017 | 0.0330 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FGB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGB | 2244 | 0 | 14 | 16 | |
| GSE20123 | FGB | 2244 | 0 | 14 | 16 | |
| GSE43470 | FGB | 2244 | 0 | 13 | 30 | |
| GSE46452 | FGB | 2244 | 1 | 36 | 22 | |
| GSE47630 | FGB | 2244 | 0 | 23 | 17 | |
| GSE54993 | FGB | 2244 | 10 | 0 | 60 | |
| GSE54994 | FGB | 2244 | 1 | 13 | 39 | |
| GSE60625 | FGB | 2244 | 0 | 1 | 10 | |
| GSE74703 | FGB | 2244 | 0 | 11 | 25 | |
| GSE74704 | FGB | 2244 | 0 | 7 | 13 | |
| TCGA | FGB | 2244 | 10 | 34 | 52 |
Total number of gains: 22; Total number of losses: 166; Total Number of normals: 300.
Somatic mutations of FGB:
Generating mutation plots.
Highly correlated genes for FGB:
Showing top 20/284 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGB | LZTS1 | 0.704801 | 3 | 0 | 3 |
| FGB | HOXA11-AS | 0.68067 | 3 | 0 | 3 |
| FGB | TLL1 | 0.672808 | 3 | 0 | 3 |
| FGB | GJB1 | 0.665178 | 5 | 0 | 5 |
| FGB | IGFALS | 0.663426 | 6 | 0 | 5 |
| FGB | LYZL6 | 0.660496 | 3 | 0 | 3 |
| FGB | IL13 | 0.657353 | 6 | 0 | 5 |
| FGB | NECAB2 | 0.657116 | 3 | 0 | 3 |
| FGB | SOX3 | 0.654109 | 3 | 0 | 3 |
| FGB | FKBP6 | 0.653228 | 6 | 0 | 6 |
| FGB | CELF3 | 0.651958 | 6 | 0 | 5 |
| FGB | CASC18 | 0.64942 | 3 | 0 | 3 |
| FGB | GGT5 | 0.647447 | 3 | 0 | 3 |
| FGB | MAPRE3 | 0.642843 | 4 | 0 | 3 |
| FGB | INSL5 | 0.640663 | 4 | 0 | 3 |
| FGB | TSC22D4 | 0.639134 | 4 | 0 | 3 |
| FGB | CDH15 | 0.636625 | 4 | 0 | 3 |
| FGB | AIPL1 | 0.634955 | 5 | 0 | 3 |
| FGB | ZG16 | 0.633102 | 3 | 0 | 3 |
| FGB | NYX | 0.631867 | 5 | 0 | 4 |
For details and further investigation, click here
