| Full name: branched chain keto acid dehydrogenase E1 subunit alpha | Alias Symbol: MSU | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 593 | HGNC ID: HGNC:986 | Ensembl Gene: ENSG00000248098 | OMIM ID: 608348 |
| Drug and gene relationship at DGIdb | |||
Expression of BCKDHA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BCKDHA | 593 | 202331_at | -0.6030 | 0.1292 | |
| GSE20347 | BCKDHA | 593 | 202331_at | -0.7651 | 0.0000 | |
| GSE23400 | BCKDHA | 593 | 202331_at | -0.3931 | 0.0000 | |
| GSE26886 | BCKDHA | 593 | 202331_at | -0.6310 | 0.0019 | |
| GSE29001 | BCKDHA | 593 | 202331_at | -0.8165 | 0.0022 | |
| GSE38129 | BCKDHA | 593 | 202331_at | -0.5713 | 0.0000 | |
| GSE45670 | BCKDHA | 593 | 202331_at | -0.5024 | 0.0008 | |
| GSE53622 | BCKDHA | 593 | 150625 | -0.1352 | 0.1335 | |
| GSE53624 | BCKDHA | 593 | 150625 | -0.0316 | 0.7266 | |
| GSE63941 | BCKDHA | 593 | 202331_at | 1.0904 | 0.0236 | |
| GSE77861 | BCKDHA | 593 | 202331_at | -0.6489 | 0.1309 | |
| GSE97050 | BCKDHA | 593 | A_33_P3236628 | -0.0648 | 0.8251 | |
| SRP007169 | BCKDHA | 593 | RNAseq | -2.2502 | 0.0000 | |
| SRP008496 | BCKDHA | 593 | RNAseq | -2.3669 | 0.0000 | |
| SRP064894 | BCKDHA | 593 | RNAseq | -0.8470 | 0.0008 | |
| SRP133303 | BCKDHA | 593 | RNAseq | -0.8057 | 0.0015 | |
| SRP159526 | BCKDHA | 593 | RNAseq | -0.7631 | 0.0001 | |
| SRP193095 | BCKDHA | 593 | RNAseq | -0.9410 | 0.0000 | |
| SRP219564 | BCKDHA | 593 | RNAseq | -0.9247 | 0.0482 | |
| TCGA | BCKDHA | 593 | RNAseq | -0.1910 | 0.0011 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by BCKDHA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BCKDHA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BCKDHA | 593 | 4 | 4 | 22 | |
| GSE20123 | BCKDHA | 593 | 4 | 3 | 23 | |
| GSE43470 | BCKDHA | 593 | 3 | 11 | 29 | |
| GSE46452 | BCKDHA | 593 | 48 | 1 | 10 | |
| GSE47630 | BCKDHA | 593 | 9 | 5 | 26 | |
| GSE54993 | BCKDHA | 593 | 17 | 4 | 49 | |
| GSE54994 | BCKDHA | 593 | 7 | 11 | 35 | |
| GSE60625 | BCKDHA | 593 | 9 | 0 | 2 | |
| GSE74703 | BCKDHA | 593 | 3 | 7 | 26 | |
| GSE74704 | BCKDHA | 593 | 4 | 1 | 15 | |
| TCGA | BCKDHA | 593 | 14 | 16 | 66 |
Total number of gains: 122; Total number of losses: 63; Total Number of normals: 303.
Somatic mutations of BCKDHA:
Generating mutation plots.
Highly correlated genes for BCKDHA:
Showing top 20/657 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BCKDHA | FAM214A | 0.792814 | 3 | 0 | 3 |
| BCKDHA | ESPNL | 0.780756 | 3 | 0 | 3 |
| BCKDHA | GPR78 | 0.77753 | 3 | 0 | 3 |
| BCKDHA | B3GNT8 | 0.76254 | 5 | 0 | 5 |
| BCKDHA | RAET1E | 0.750865 | 4 | 0 | 4 |
| BCKDHA | PGC | 0.745794 | 3 | 0 | 3 |
| BCKDHA | EPS8L2 | 0.745513 | 9 | 0 | 9 |
| BCKDHA | C11orf86 | 0.741363 | 3 | 0 | 3 |
| BCKDHA | CCR6 | 0.741136 | 3 | 0 | 3 |
| BCKDHA | MAB21L3 | 0.739637 | 3 | 0 | 3 |
| BCKDHA | MMEL1 | 0.737661 | 4 | 0 | 3 |
| BCKDHA | TMEM101 | 0.737619 | 3 | 0 | 3 |
| BCKDHA | OTOF | 0.735964 | 3 | 0 | 3 |
| BCKDHA | GRHL1 | 0.733941 | 4 | 0 | 4 |
| BCKDHA | GGT6 | 0.730916 | 5 | 0 | 4 |
| BCKDHA | LINC00330 | 0.730764 | 3 | 0 | 3 |
| BCKDHA | SCNN1B | 0.727019 | 9 | 0 | 9 |
| BCKDHA | CRISP3 | 0.726313 | 7 | 0 | 7 |
| BCKDHA | SPINK7 | 0.725025 | 4 | 0 | 4 |
| BCKDHA | SLURP1 | 0.72498 | 8 | 0 | 8 |
For details and further investigation, click here
